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C. lupus familiaris Gene: TLR4 - ENSCAFG00000003518 - Canis lupus familiaris (dog)

General information

Ensembl IDENSCAFG00000003518
NameTLR4
Descriptiontoll-like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850]
OrganismCanis lupus familiaris (dog)
Synonym(s)armd10, cd284, htoll, tlr-4
Orthologs(s)19 orthologs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
CL:0000094granulocyte
  • UBERON:0000104life cycle
1.57e3
  • 1.57e3
92.99
  • 92.99
AEIR
  • AEIR
UBERON:0000955brain
  • UBERON:0018241prime adult stage
  • UBERON:0000104life cycle
2.29e3
  • 2.29e3
  • 1.39e4
89.77
  • 89.77
  • 37.98
AEIR
  • AEIR
  • AEIR
UBERON:0000178blood
  • UBERON:0000104life cycle
2.99e3
  • 2.99e3
86.65
  • 86.65
AEIR
  • AEIR
UBERON:0002418cartilage tissue
  • UBERON:0007222late adult stage
3.02e3
  • 3.02e3
86.52
  • 86.52
AEIR
  • AEIR
UBERON:0002106spleen
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
3.33e3
  • 3.33e3
  • 4.76e3
  • 5.27e3
85.13
  • 85.13
  • 78.71
  • 76.45
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000029lymph node
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
4.75e3
  • 4.75e3
  • 6.61e3
78.76
  • 78.76
  • 70.46
AEIR
  • AEIR
  • AEIR
UBERON:0001044saliva-secreting gland
  • UBERON:0007222late adult stage
5.24e3
  • 5.24e3
76.57
  • 76.57
AEIR
  • AEIR
UBERON:0002048lung
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
  • UBERON:0000112sexually immature stage
5.51e3
  • 5.51e3
  • 7.07e3
  • 1.22e4
75.38
  • 75.38
  • 68.41
  • 45.47
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000014zone of skin
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
5.56e3
  • 5.56e3
  • 1.04e4
75.14
  • 75.14
  • 53.56
AEIR
  • AEIR
  • AEIR
UBERON:0001013adipose tissue
  • UBERON:0007222late adult stage
6.31e3
  • 6.31e3
71.77
  • 71.77
AEIR
  • AEIR
UBERON:0001259mucosa of urinary bladder
  • UBERON:0000104life cycle
6.48e3
  • 6.48e3
71.01
  • 71.01
AEIR
  • AEIR
UBERON:0000082adult mammalian kidney
  • UBERON:0018241prime adult stage
  • UBERON:0000112sexually immature stage
6.55e3
  • 6.55e3
  • 1.31e4
70.71
  • 70.71
  • 41.57
AEIR
  • AEIR
  • AEIR
UBERON:0002371bone marrow
  • UBERON:0007222late adult stage
6.83e3
  • 6.83e3
69.48
  • 69.48
AEIR
  • AEIR
UBERON:0000966retina
  • UBERON:0000104life cycle
6.89e3
  • 6.89e3
69.19
  • 69.19
AEIR
  • AEIR
UBERON:0001911mammary gland
  • UBERON:0018241prime adult stage
  • UBERON:0000104life cycle
7.27e3
  • 7.27e3
  • 9.34e3
67.48
  • 67.48
  • 58.23
AEIR
  • AEIR
  • AEIR
UBERON:0001264pancreas
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
  • UBERON:0000113post-juvenile adult stage
7.66e3
  • 7.66e3
  • 7.67e3
  • 1.06e4
65.76
  • 65.76
  • 65.71
  • 52.65
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002046thyroid gland
  • UBERON:0007222late adult stage
8.08e3
  • 8.08e3
63.86
  • 63.86
AEIR
  • AEIR
UBERON:0002135mitral valve
  • UBERON:0007222late adult stage
  • UBERON:0018241prime adult stage
8.32e3
  • 8.32e3
  • 1.03e4
62.79
  • 62.79
  • 54.13
AEIR
  • AEIR
  • AEIR
UBERON:0002080heart right ventricle
  • UBERON:0007222late adult stage
8.44e3
  • 8.44e3
62.26
  • 62.26
AEIR
  • AEIR
UBERON:0010533metanephros cortex
  • UBERON:0007222late adult stage
8.56e3
  • 8.56e3
61.73
  • 61.73
AEIR
  • AEIR
UBERON:0002369adrenal gland
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
8.56e3
  • 8.56e3
  • 9.77e3
61.71
  • 61.71
  • 56.33
AEIR
  • AEIR
  • AEIR
UBERON:0000945stomach
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0007222late adult stage
8.67e3
  • 8.67e3
  • 9.04e3
61.25
  • 61.25
  • 59.58
AEIR
  • AEIR
  • AEIR
UBERON:0003382cardiac muscle of left ventricle
  • UBERON:0000104life cycle
8.75e3
  • 8.75e3
60.86
  • 60.86
AEIR
  • AEIR
UBERON:0000362renal medulla
  • UBERON:0007222late adult stage
8.83e3
  • 8.83e3
60.53
  • 60.53
AEIR
  • AEIR
UBERON:0002078right cardiac atrium
  • UBERON:0007222late adult stage
8.89e3
  • 8.89e3
60.27
  • 60.27
AEIR
  • AEIR
UBERON:0002084heart left ventricle
  • UBERON:0007222late adult stage
  • UBERON:0018241prime adult stage
9.02e3
  • 9.02e3
  • 9.62e3
59.68
  • 59.68
  • 56.99
AEIR
  • AEIR
  • AEIR
UBERON:0002240spinal cord
  • UBERON:0000104life cycle
9.48e3
  • 9.48e3
57.59
  • 57.59
AEIR
  • AEIR
UBERON:0001723tongue
  • UBERON:0000113post-juvenile adult stage
9.70e3
  • 9.70e3
56.64
  • 56.64
AEIR
  • AEIR
UBERON:0002107liver
  • UBERON:0018241prime adult stage
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0007222late adult stage
  • UBERON:0000112sexually immature stage
  • UBERON:0000104life cycle
9.75e3
  • 9.75e3
  • 9.85e3
  • 9.93e3
  • 1.15e4
  • 1.21e4
56.39
  • 56.39
  • 55.98
  • 55.61
  • 48.49
  • 46.01
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001235adrenal cortex
  • UBERON:0018241prime adult stage
9.78e3
  • 9.78e3
56.25
  • 56.25
AEIR
  • AEIR
UBERON:0001255urinary bladder
  • UBERON:0007222late adult stage
9.83e3
  • 9.83e3
56.04
  • 56.04
AEIR
  • AEIR
UBERON:0001155colon
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
1.02e4
  • 1.02e4
  • 1.05e4
54.20
  • 54.20
  • 53.10
AEIR
  • AEIR
  • AEIR
UBERON:0002370thymus
  • UBERON:0000104life cycle
1.03e4
  • 1.03e4
53.91
  • 53.91
AEIR
  • AEIR
UBERON:0002264olfactory bulb
  • UBERON:0000104life cycle
1.04e4
  • 1.04e4
53.54
  • 53.54
AEIR
  • AEIR
UBERON:0001135smooth muscle tissue
  • UBERON:0000104life cycle
1.06e4
  • 1.06e4
52.54
  • 52.54
AEIR
  • AEIR
UBERON:0001134skeletal muscle tissue
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
1.07e4
  • 1.07e4
  • 1.09e4
52.14
  • 52.14
  • 51.15
AEIR
  • AEIR
  • AEIR
UBERON:0000948heart
  • UBERON:0000104life cycle
  • UBERON:0000112sexually immature stage
1.08e4
  • 1.08e4
  • 1.25e4
51.88
  • 51.88
  • 43.90
AEIR
  • AEIR
  • AEIR
UBERON:0001898hypothalamus
  • UBERON:0000104life cycle
1.09e4
  • 1.09e4
51.43
  • 51.43
AEIR
  • AEIR
UBERON:0002073hair follicle
  • UBERON:0000104life cycle
1.10e4
  • 1.10e4
50.83
  • 50.83
AEIR
  • AEIR
UBERON:0000007pituitary gland
  • UBERON:0007222late adult stage
  • UBERON:0018241prime adult stage
1.10e4
  • 1.10e4
  • 1.10e4
50.78
  • 50.78
  • 50.65
AEIR
  • AEIR
  • AEIR
UBERON:0002037cerebellum
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
1.11e4
  • 1.11e4
  • 1.21e4
50.42
  • 50.42
  • 45.72
AEIR
  • AEIR
  • AEIR
UBERON:0002108small intestine
  • UBERON:0007222late adult stage
  • UBERON:0000113post-juvenile adult stage
1.14e4
  • 1.14e4
  • 1.18e4
49.04
  • 49.04
  • 47.37
AEIR
  • AEIR
  • AEIR
UBERON:0016540occipital cortex
  • UBERON:0007222late adult stage
1.15e4
  • 1.15e4
48.70
  • 48.70
AEIR
  • AEIR
UBERON:0001987placenta
  • UBERON:0000113post-juvenile adult stage
1.15e4
  • 1.15e4
48.59
  • 48.59
AEIR
  • AEIR
UBERON:0000004nose
  • UBERON:0000104life cycle
1.20e4
  • 1.20e4
46.52
  • 46.52
AEIR
  • AEIR
UBERON:0000451prefrontal cortex
  • UBERON:0018241prime adult stage
1.21e4
  • 1.21e4
46.01
  • 46.01
AEIR
  • AEIR
UBERON:0002115jejunum
  • UBERON:0000104life cycle
1.23e4
  • 1.23e4
45.22
  • 45.22
AEIR
  • AEIR
UBERON:0001870frontal cortex
  • UBERON:0007222late adult stage
1.25e4
  • 1.25e4
44.23
  • 44.23
AEIR
  • AEIR
UBERON:0000992female gonad
  • UBERON:0000104life cycle
1.27e4
  • 1.27e4
43.02
  • 43.02
AEIR
  • AEIR
UBERON:0000033head
  • UBERON:0000112sexually immature stage
1.35e4
  • 1.35e4
39.56
  • 39.56
AEIR
  • AEIR
UBERON:0001871temporal lobe
  • UBERON:0000113post-juvenile adult stage
1.40e4
  • 1.40e4
37.30
  • 37.30
AEIR
  • AEIR
UBERON:0000473testis
  • UBERON:0000104life cycle
1.63e4
  • 1.63e4
27.06
  • 27.06
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
  • RNA-Seq data: Bgee
Sources of raw data:
  • RNA-Seq data: GEO

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
Carnivora1 species1 geneCompare expression
Laurasiatheria5 species5 genesCompare expression
Boreoeutheria13 species13 genesCompare expression
Mammalia14 species14 genesCompare expression
Amniota16 species16 genesCompare expression
Euteleostomi17 species19 genesCompare expression

Orthology information comes from OMA : ENSCAFG00000003518.

Cross-references

EnsemblENSCAFG00000003518 (TLR4)
HGNCHGNC:11850 (TLR4)
EMBLAAEX03008139
Uniprot/SPTREMBLF1PDB9, F1PDB9_CANLF

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