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C. lupus familiaris Gene: GCH1 - ENSCAFG00000014965 - Canis lupus familiaris (dog)

General information

Ensembl IDENSCAFG00000014965
NameGCH1
DescriptionGTP cyclohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:4193]
OrganismCanis lupus familiaris (dog)
Synonym(s)dyt14, dyt5, dyt5a, gch, gtpch1
Orthologs(s)13 orthologs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0002107liver
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0018241prime adult stage
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
  • UBERON:0000112sexually immature stage
2.17e3
  • 2.17e3
  • 2.37e3
  • 2.61e3
  • 3.02e3
  • 5.76e3
90.28
  • 90.28
  • 89.40
  • 88.35
  • 86.50
  • 74.26
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002106spleen
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.84e3
  • 2.84e3
  • 9.90e3
  • 1.06e4
87.32
  • 87.32
  • 55.72
  • 52.70
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001235adrenal cortex
  • UBERON:0018241prime adult stage
4.64e3
  • 4.64e3
79.26
  • 79.26
AEIR
  • AEIR
UBERON:0002115jejunum
  • UBERON:0000104life cycle
5.78e3
  • 5.78e3
74.15
  • 74.15
AEIR
  • AEIR
UBERON:0002113kidney
  • UBERON:0000104life cycle
6.36e3
  • 6.36e3
71.55
  • 71.55
AEIR
  • AEIR
UBERON:0000362renal medulla
  • UBERON:0007222late adult stage
6.59e3
  • 6.59e3
70.53
  • 70.53
AEIR
  • AEIR
UBERON:0000029lymph node
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
6.65e3
  • 6.65e3
  • 8.39e3
70.27
  • 70.27
  • 62.49
AEIR
  • AEIR
  • AEIR
UBERON:0000059large intestine
  • UBERON:0000113post-juvenile adult stage
7.03e3
  • 7.03e3
68.58
  • 68.58
AEIR
  • AEIR
UBERON:0010533metanephros cortex
  • UBERON:0007222late adult stage
7.31e3
  • 7.31e3
67.33
  • 67.33
AEIR
  • AEIR
UBERON:0000082adult mammalian kidney
  • UBERON:0018241prime adult stage
  • UBERON:0000112sexually immature stage
7.63e3
  • 7.63e3
  • 1.18e4
65.89
  • 65.89
  • 47.41
AEIR
  • AEIR
  • AEIR
UBERON:0002418cartilage tissue
  • UBERON:0007222late adult stage
7.91e3
  • 7.91e3
64.62
  • 64.62
AEIR
  • AEIR
UBERON:0000007pituitary gland
  • UBERON:0007222late adult stage
  • UBERON:0018241prime adult stage
7.93e3
  • 7.93e3
  • 9.57e3
64.56
  • 64.56
  • 57.20
AEIR
  • AEIR
  • AEIR
UBERON:0002048lung
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
  • UBERON:0000112sexually immature stage
7.99e3
  • 7.99e3
  • 8.60e3
  • 1.44e4
64.26
  • 64.26
  • 61.57
  • 35.46
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002371bone marrow
  • UBERON:0007222late adult stage
8.09e3
  • 8.09e3
63.81
  • 63.81
AEIR
  • AEIR
UBERON:0001987placenta
  • UBERON:0000113post-juvenile adult stage
8.11e3
  • 8.11e3
63.74
  • 63.74
AEIR
  • AEIR
UBERON:0000014zone of skin
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
8.36e3
  • 8.36e3
  • 1.34e4
62.63
  • 62.63
  • 39.96
AEIR
  • AEIR
  • AEIR
UBERON:0000178blood
  • UBERON:0000104life cycle
8.59e3
  • 8.59e3
61.61
  • 61.61
AEIR
  • AEIR
UBERON:0001013adipose tissue
  • UBERON:0007222late adult stage
8.62e3
  • 8.62e3
61.47
  • 61.47
AEIR
  • AEIR
UBERON:0001264pancreas
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
8.70e3
  • 8.70e3
  • 1.06e4
  • 1.19e4
61.11
  • 61.11
  • 52.76
  • 46.74
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001911mammary gland
  • UBERON:0018241prime adult stage
  • UBERON:0000104life cycle
8.90e3
  • 8.90e3
  • 1.25e4
60.20
  • 60.20
  • 44.01
AEIR
  • AEIR
  • AEIR
UBERON:0002108small intestine
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0007222late adult stage
9.01e3
  • 9.01e3
  • 1.06e4
59.70
  • 59.70
  • 52.74
AEIR
  • AEIR
  • AEIR
CL:0000312keratinocyte
  • UBERON:0000104life cycle
9.13e3
  • 9.13e3
59.17
  • 59.17
AEIR
  • AEIR
UBERON:0001155colon
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
9.20e3
  • 9.20e3
  • 1.19e4
58.85
  • 58.85
  • 46.78
AEIR
  • AEIR
  • AEIR
UBERON:0003382cardiac muscle of left ventricle
  • UBERON:0000104life cycle
9.44e3
  • 9.44e3
57.81
  • 57.81
AEIR
  • AEIR
CL:0000094granulocyte
  • UBERON:0000104life cycle
1.01e4
  • 1.01e4
54.69
  • 54.69
AEIR
  • AEIR
UBERON:0001135smooth muscle tissue
  • UBERON:0000104life cycle
1.02e4
  • 1.02e4
54.26
  • 54.26
AEIR
  • AEIR
UBERON:0002079left cardiac atrium
  • UBERON:0007222late adult stage
1.03e4
  • 1.03e4
54.16
  • 54.16
AEIR
  • AEIR
UBERON:0002369adrenal gland
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
1.03e4
  • 1.03e4
  • 1.05e4
54.08
  • 54.08
  • 53.06
AEIR
  • AEIR
  • AEIR
UBERON:0001723tongue
  • UBERON:0000113post-juvenile adult stage
1.03e4
  • 1.03e4
53.90
  • 53.90
AEIR
  • AEIR
UBERON:0001134skeletal muscle tissue
  • UBERON:0000104life cycle
  • UBERON:0007222late adult stage
1.03e4
  • 1.03e4
  • 1.05e4
53.83
  • 53.83
  • 52.86
AEIR
  • AEIR
  • AEIR
UBERON:0000945stomach
  • UBERON:0007222late adult stage
  • UBERON:0000113post-juvenile adult stage
1.04e4
  • 1.04e4
  • 1.22e4
53.62
  • 53.62
  • 45.39
AEIR
  • AEIR
  • AEIR
UBERON:0002080heart right ventricle
  • UBERON:0007222late adult stage
1.09e4
  • 1.09e4
51.42
  • 51.42
AEIR
  • AEIR
UBERON:0000948heart
  • UBERON:0000104life cycle
  • UBERON:0000112sexually immature stage
1.09e4
  • 1.09e4
  • 1.13e4
51.35
  • 51.35
  • 49.63
AEIR
  • AEIR
  • AEIR
UBERON:0002084heart left ventricle
  • UBERON:0007222late adult stage
  • UBERON:0018241prime adult stage
1.09e4
  • 1.09e4
  • 1.14e4
51.24
  • 51.24
  • 49.21
AEIR
  • AEIR
  • AEIR
UBERON:0002073hair follicle
  • UBERON:0000104life cycle
1.15e4
  • 1.15e4
48.74
  • 48.74
AEIR
  • AEIR
UBERON:0000992female gonad
  • UBERON:0000104life cycle
1.16e4
  • 1.16e4
48.24
  • 48.24
AEIR
  • AEIR
UBERON:0002240spinal cord
  • UBERON:0000104life cycle
1.17e4
  • 1.17e4
47.89
  • 47.89
AEIR
  • AEIR
UBERON:0000966retina
  • UBERON:0000104life cycle
1.17e4
  • 1.17e4
47.87
  • 47.87
AEIR
  • AEIR
UBERON:0001259mucosa of urinary bladder
  • UBERON:0000104life cycle
1.17e4
  • 1.17e4
47.71
  • 47.71
AEIR
  • AEIR
UBERON:0002078right cardiac atrium
  • UBERON:0007222late adult stage
1.17e4
  • 1.17e4
47.60
  • 47.60
AEIR
  • AEIR
UBERON:0002264olfactory bulb
  • UBERON:0000104life cycle
1.18e4
  • 1.18e4
47.18
  • 47.18
AEIR
  • AEIR
UBERON:0001044saliva-secreting gland
  • UBERON:0007222late adult stage
1.19e4
  • 1.19e4
46.64
  • 46.64
AEIR
  • AEIR
UBERON:0001255urinary bladder
  • UBERON:0007222late adult stage
1.21e4
  • 1.21e4
45.74
  • 45.74
AEIR
  • AEIR
UBERON:0002135mitral valve
  • UBERON:0018241prime adult stage
1.22e4
  • 1.22e4
45.53
  • 45.53
AEIR
  • AEIR
UBERON:0002370thymus
  • UBERON:0000104life cycle
1.24e4
  • 1.24e4
44.73
  • 44.73
AEIR
  • AEIR
UBERON:0002046thyroid gland
  • UBERON:0007222late adult stage
1.31e4
  • 1.31e4
41.38
  • 41.38
AEIR
  • AEIR
UBERON:0002021occipital lobe
  • UBERON:0000113post-juvenile adult stage
1.31e4
  • 1.31e4
41.36
  • 41.36
AEIR
  • AEIR
UBERON:0001898hypothalamus
  • UBERON:0000104life cycle
1.33e4
  • 1.33e4
40.45
  • 40.45
AEIR
  • AEIR
UBERON:0001871temporal lobe
  • UBERON:0000113post-juvenile adult stage
1.38e4
  • 1.38e4
38.28
  • 38.28
AEIR
  • AEIR
UBERON:0000033head
  • UBERON:0000112sexually immature stage
1.38e4
  • 1.38e4
38.19
  • 38.19
AEIR
  • AEIR
UBERON:0000473testis
  • UBERON:0000104life cycle
1.41e4
  • 1.41e4
36.94
  • 36.94
AEIR
  • AEIR
UBERON:0016540occipital cortex
  • UBERON:0007222late adult stage
1.45e4
  • 1.45e4
34.99
  • 34.99
AEIR
  • AEIR
UBERON:0002037cerebellum
  • UBERON:0007222late adult stage
  • UBERON:0000104life cycle
1.46e4
  • 1.46e4
  • 1.50e4
34.90
  • 34.90
  • 32.73
AEIR
  • AEIR
  • AEIR
UBERON:0000004nose
  • UBERON:0000104life cycle
1.47e4
  • 1.47e4
34.23
  • 34.23
AEIR
  • AEIR
UBERON:0000451prefrontal cortex
  • UBERON:0018241prime adult stage
1.52e4
  • 1.52e4
31.95
  • 31.95
AEIR
  • AEIR
UBERON:0001870frontal cortex
  • UBERON:0007222late adult stage
1.62e4
  • 1.62e4
27.42
  • 27.42
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
  • RNA-Seq data: Bgee
Sources of raw data:
  • RNA-Seq data: GEO

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
Laurasiatheria2 species2 genesCompare expression
Boreoeutheria10 species10 genesCompare expression
Amniota11 species11 genesCompare expression
Tetrapoda12 species12 genesCompare expression
Euteleostomi13 species13 genesCompare expression

Orthology information comes from OMA : ENSCAFG00000014965.

Cross-references

EnsemblENSCAFG00000014965 (GCH1)
HGNCHGNC:4193 (GCH1)
EMBLAAEX03005743
Uniprot/SPTREMBLE2RI70, E2RI70_CANLF

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