D. rerio Gene: mdkb - ENSDARG00000020708 - Danio rerio (zebrafish)

General information

Ensembl IDENSDARG00000020708
Namemdkb
Descriptionmidkine b [Source:ZFIN;Acc:ZDB-GENE-010131-6]
OrganismDanio rerio (zebrafish)
Synonym(s)cb518, fb79b05, fj33b02, fj48a12, mdk, mdk2, plei2, pleiotrophin 2, wu:fb79b05, wu:fj33b02, wu:fj48a12
Orthologs(s)14 orthologs
Paralog(s)1 paralogs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0000955brain
  • UBERON:0000066fully formed stage
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000026Segmentation:14-19 somites
  • UBERON:0000104life cycle
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000025Segmentation:10-13 somites
120
  • 120
  • 1.57e3
  • 5.97e3
  • 7.06e3
  • 1.19e4
  • 1.49e4
99.60
  • 99.60
  • 94.74
  • 80.00
  • 76.36
  • 59.99
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000033head
  • ZFS:0000037Larval:Day 5
  • UBERON:0000066fully formed stage
207
  • 207
  • 1.00e3
99.31
  • 99.31
  • 96.65
AEIR
  • AEIR
  • AEIR
UBERON:0000468multi-cellular organism
  • ZFS:0000037Larval:Day 5
  • ZFS:0000036Larval:Day 4
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000040Larval:Days 14-20
  • ZFS:0000022Gastrula:Bud
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000021Gastrula:90%-epiboly
  • ZFS:0000042Juvenile:Days 30-44
  • ZFS:0000020Gastrula:75%-epiboly
  • ZFS:0000028Segmentation:26+ somites
  • ZFS:0000019Gastrula:Shield
  • UBERON:0000068embryo stage
  • ZFS:0000049segmentation
  • UBERON:0000104life cycle
  • UBERON:0000066fully formed stage
323
  • 323
  • 630
  • 658
  • 743
  • 893
  • 921
  • 1.05e3
  • 1.12e3
  • 1.17e3
  • 1.55e3
  • 1.81e3
  • 2.21e3
  • 4.27e3
  • 1.10e4
  • 1.20e4
  • 1.35e4
  • 1.47e4
  • 1.50e4
98.92
  • 98.92
  • 97.89
  • 97.80
  • 97.52
  • 97.01
  • 96.92
  • 96.49
  • 96.26
  • 96.09
  • 94.81
  • 93.95
  • 92.59
  • 85.71
  • 63.23
  • 59.92
  • 54.64
  • 50.90
  • 49.81
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000922embryo
  • ZFS:0000037Larval:Day 5
  • UBERON:0000068embryo stage
  • UBERON:0004707pharyngula stage
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000025Segmentation:10-13 somites
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000031Pharyngula:Prim-25
371
  • 371
  • 763
  • 804
  • 817
  • 957
  • 1.06e3
  • 1.33e3
  • 2.23e3
  • 3.43e3
  • 9.67e3
98.76
  • 98.76
  • 97.45
  • 97.31
  • 97.27
  • 96.80
  • 96.45
  • 95.55
  • 92.55
  • 88.53
  • 67.61
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000966retina
  • ZFS:0000037Larval:Day 5
  • UBERON:0000066fully formed stage
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000031Pharyngula:Prim-25
516
  • 516
  • 6.01e3
  • 6.71e3
  • 1.04e4
98.27
  • 98.27
  • 79.88
  • 77.55
  • 65.20
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002548larva
  • ZFS:0000037Larval:Day 5
  • ZFS:0000035Larval:Protruding-mouth
  • UBERON:0000069larval stage
546
  • 546
  • 924
  • 1.31e3
98.17
  • 98.17
  • 96.91
  • 95.61
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000970eye
  • ZFS:0000031Pharyngula:Prim-25
559
  • 559
98.13
  • 98.13
AEIR
  • AEIR
UBERON:0004734gastrula
  • ZFS:0000022Gastrula:Bud
  • ZFS:0000021Gastrula:90%-epiboly
  • ZFS:0000020Gastrula:75%-epiboly
  • ZFS:0000017Gastrula:50%-epiboly
  • UBERON:0000109gastrula stage
  • ZFS:0000019Gastrula:Shield
761
  • 761
  • 2.46e3
  • 3.73e3
  • 4.24e3
  • 9.49e3
  • 1.36e4
97.45
  • 97.45
  • 91.77
  • 87.50
  • 85.80
  • 68.22
  • 54.48
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000948heart
  • ZFS:0000036Larval:Day 4
  • UBERON:0000066fully formed stage
1.43e3
  • 1.43e3
  • 6.33e3
95.21
  • 95.21
  • 78.81
AEIR
  • AEIR
  • AEIR
UBERON:0002481bone tissue
  • UBERON:0000066fully formed stage
1.88e3
  • 1.88e3
93.71
  • 93.71
AEIR
  • AEIR
UBERON:0009620tail bud paraxial mesoderm
  • ZFS:0000027Segmentation:20-25 somites
2.51e3
  • 2.51e3
91.60
  • 91.60
AEIR
  • AEIR
UBERON:2007046midbrain hindbrain boundary neural rod
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000025Segmentation:10-13 somites
4.98e3
  • 4.98e3
  • 1.24e4
83.33
  • 83.33
  • 58.33
AEIR
  • AEIR
  • AEIR
UBERON:4000164caudal fin
  • ZFS:0000033Hatching:Long-pec
  • UBERON:0000066fully formed stage
5.19e3
  • 5.19e3
  • 1.19e4
82.64
  • 82.64
  • 60.05
AEIR
  • AEIR
  • AEIR
UBERON:0002037cerebellum
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000027Segmentation:20-25 somites
  • ZFS:0000028Segmentation:26+ somites
5.81e3
  • 5.81e3
  • 6.54e3
  • 8.96e3
  • 9.96e3
  • 9.96e3
80.55
  • 80.55
  • 78.12
  • 69.99
  • 66.65
  • 66.65
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002028hindbrain
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000027Segmentation:20-25 somites
  • ZFS:0000028Segmentation:26+ somites
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000032Pharyngula:High-pec
5.98e3
  • 5.98e3
  • 7.80e3
  • 8.01e3
  • 9.25e3
  • 1.05e4
  • 1.05e4
  • 1.20e4
  • 1.26e4
79.99
  • 79.99
  • 73.90
  • 73.19
  • 69.03
  • 64.98
  • 64.98
  • 59.98
  • 57.87
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002082cardiac ventricle
  • UBERON:0000066fully formed stage
6.03e3
  • 6.03e3
79.81
  • 79.81
AEIR
  • AEIR
UBERON:0001893telencephalon
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000027Segmentation:20-25 somites
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000028Segmentation:26+ somites
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000032Pharyngula:High-pec
  • ZFS:0000031Pharyngula:Prim-25
6.29e3
  • 6.29e3
  • 1.02e4
  • 1.06e4
  • 1.08e4
  • 1.16e4
  • 1.21e4
  • 1.26e4
78.94
  • 78.94
  • 65.77
  • 64.56
  • 63.87
  • 61.09
  • 59.36
  • 57.87
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001049neural tube
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000027Segmentation:20-25 somites
  • ZFS:0000028Segmentation:26+ somites
6.72e3
  • 6.72e3
  • 1.04e4
  • 1.12e4
  • 1.12e4
77.49
  • 77.49
  • 65.19
  • 62.48
  • 62.48
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001891midbrain
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000026Segmentation:14-19 somites
7.03e3
  • 7.03e3
  • 9.13e3
  • 1.20e4
  • 1.28e4
76.46
  • 76.46
  • 69.43
  • 59.98
  • 57.12
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
CL:0000561amacrine cell
  • ZFS:0000036Larval:Day 4
  • ZFS:0000037Larval:Day 5
  • ZFS:0000035Larval:Protruding-mouth
7.47e3
  • 7.47e3
  • 1.49e4
  • 1.49e4
75.00
  • 75.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0010312immature eye
  • ZFS:0000024Segmentation:5-9 somites
7.47e3
  • 7.47e3
75.00
  • 75.00
AEIR
  • AEIR
UBERON:0014371future telencephalon
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000025Segmentation:10-13 somites
  • ZFS:0000023Segmentation:1-4 somites
7.47e3
  • 7.47e3
  • 1.15e4
  • 1.24e4
74.99
  • 74.99
  • 61.53
  • 58.32
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0003052midbrain-hindbrain boundary
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000027Segmentation:20-25 somites
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000028Segmentation:26+ somites
7.83e3
  • 7.83e3
  • 9.67e3
  • 1.03e4
  • 1.03e4
  • 1.07e4
  • 1.08e4
73.79
  • 73.79
  • 67.63
  • 65.61
  • 65.37
  • 64.27
  • 63.87
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0003075neural plate
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000021Gastrula:90%-epiboly
  • ZFS:0000023Segmentation:1-4 somites
  • ZFS:0000022Gastrula:Bud
  • ZFS:0000025Segmentation:10-13 somites
  • ZFS:0000020Gastrula:75%-epiboly
7.86e3
  • 7.86e3
  • 1.03e4
  • 1.14e4
  • 1.20e4
  • 1.26e4
  • 1.26e4
73.67
  • 73.67
  • 65.37
  • 61.88
  • 59.98
  • 57.87
  • 57.68
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002240spinal cord
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000027Segmentation:20-25 somites
  • ZFS:0000028Segmentation:26+ somites
8.01e3
  • 8.01e3
  • 1.12e4
  • 1.12e4
73.19
  • 73.19
  • 62.48
  • 62.48
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0005068neural rod
  • ZFS:0000026Segmentation:14-19 somites
8.04e3
  • 8.04e3
73.07
  • 73.07
AEIR
  • AEIR
UBERON:0001894diencephalon
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000027Segmentation:20-25 somites
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000028Segmentation:26+ somites
  • ZFS:0000032Pharyngula:High-pec
  • ZFS:0000033Hatching:Long-pec
8.09e3
  • 8.09e3
  • 8.30e3
  • 9.75e3
  • 1.04e4
  • 1.09e4
  • 1.10e4
  • 1.23e4
  • 1.25e4
72.90
  • 72.90
  • 72.21
  • 67.37
  • 65.19
  • 63.61
  • 63.14
  • 58.80
  • 58.31
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001846internal ear
  • UBERON:0000068embryo stage
8.86e3
  • 8.86e3
70.32
  • 70.32
AEIR
  • AEIR
UBERON:0003059presomitic mesoderm
  • ZFS:0000025Segmentation:10-13 somites
9.18e3
  • 9.18e3
69.26
  • 69.26
AEIR
  • AEIR
UBERON:0001792ganglionic layer of retina
  • ZFS:0000036Larval:Day 4
  • ZFS:0000037Larval:Day 5
  • ZFS:0000035Larval:Protruding-mouth
9.96e3
  • 9.96e3
  • 1.07e4
  • 1.28e4
66.67
  • 66.67
  • 64.28
  • 57.14
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006222future diencephalon
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000023Segmentation:1-4 somites
  • ZFS:0000025Segmentation:10-13 somites
1.03e4
  • 1.03e4
  • 1.12e4
  • 1.12e4
65.37
  • 65.37
  • 62.49
  • 62.49
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006860swim bladder
  • UBERON:0000066fully formed stage
1.07e4
  • 1.07e4
64.18
  • 64.18
AEIR
  • AEIR
UBERON:0001945superior colliculus
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000032Pharyngula:High-pec
1.08e4
  • 1.08e4
  • 1.08e4
  • 1.18e4
  • 1.21e4
  • 1.23e4
63.87
  • 63.87
  • 63.87
  • 60.50
  • 59.50
  • 58.80
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000160intestine
  • UBERON:0000066fully formed stage
1.12e4
  • 1.12e4
62.64
  • 62.64
AEIR
  • AEIR
UBERON:0000924ectoderm
  • ZFS:0000022Gastrula:Bud
1.12e4
  • 1.12e4
62.49
  • 62.49
AEIR
  • AEIR
UBERON:2007025midbrain neural keel
  • ZFS:0000023Segmentation:1-4 somites
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000025Segmentation:10-13 somites
1.12e4
  • 1.12e4
  • 1.12e4
  • 1.12e4
62.49
  • 62.49
  • 62.49
  • 62.49
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002199integument
  • UBERON:0000066fully formed stage
1.15e4
  • 1.15e4
61.43
  • 61.43
AEIR
  • AEIR
UBERON:0001791inner nuclear layer of retina
  • ZFS:0000037Larval:Day 5
  • ZFS:0000035Larval:Protruding-mouth
  • ZFS:0000036Larval:Day 4
1.16e4
  • 1.16e4
  • 1.22e4
  • 1.49e4
61.10
  • 61.10
  • 59.08
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0003063prechordal plate
  • ZFS:0000025Segmentation:10-13 somites
1.19e4
  • 1.19e4
60.00
  • 60.00
AEIR
  • AEIR
UBERON:0008781blastodisc derived epiblast
  • ZFS:0000019Gastrula:Shield
1.19e4
  • 1.19e4
60.00
  • 60.00
AEIR
  • AEIR
UBERON:0000206pharyngeal gill
  • UBERON:0000066fully formed stage
1.28e4
  • 1.28e4
57.12
  • 57.12
AEIR
  • AEIR
UBERON:0001892rhombomere
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000029Pharyngula:Prim-5
1.33e4
  • 1.33e4
  • 1.36e4
55.55
  • 55.55
  • 54.53
AEIR
  • AEIR
  • AEIR
UBERON:0002385muscle tissue
  • UBERON:0000066fully formed stage
1.33e4
  • 1.33e4
55.51
  • 55.51
AEIR
  • AEIR
UBERON:0007135neural keel
  • ZFS:0000022Gastrula:Bud
1.36e4
  • 1.36e4
54.53
  • 54.53
AEIR
  • AEIR
UBERON:0002107liver
  • UBERON:0000066fully formed stage
1.40e4
  • 1.40e4
53.19
  • 53.19
AEIR
  • AEIR
UBERON:0007132head kidney
  • UBERON:0000066fully formed stage
1.42e4
  • 1.42e4
52.54
  • 52.54
AEIR
  • AEIR
CL:0000094granulocyte
  • UBERON:0000066fully formed stage
1.45e4
  • 1.45e4
51.33
  • 51.33
AEIR
  • AEIR
UBERON:0001630muscle organ
  • UBERON:0000066fully formed stage
1.48e4
  • 1.48e4
50.57
  • 50.57
AEIR
  • AEIR
CL:0000740retinal ganglion cell
  • ZFS:0000036Larval:Day 4
  • ZFS:0000035Larval:Protruding-mouth
  • ZFS:0000037Larval:Day 5
1.49e4
  • 1.49e4
  • 1.49e4
  • 1.49e4
50.00
  • 50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:2007035spinal cord neural rod
  • ZFS:0000025Segmentation:10-13 somites
1.49e4
  • 1.49e4
50.00
  • 50.00
AEIR
  • AEIR
UBERON:2007043hindbrain neural tube
  • ZFS:0000026Segmentation:14-19 somites
1.49e4
  • 1.49e4
50.00
  • 50.00
AEIR
  • AEIR
UBERON:0007281presumptive midbrain hindbrain boundary
  • ZFS:0000020Gastrula:75%-epiboly
1.49e4
  • 1.49e4
50.00
  • 50.00
AEIR
  • AEIR
UBERON:0007284presumptive neural plate
  • ZFS:0000019Gastrula:Shield
  • ZFS:0000020Gastrula:75%-epiboly
1.49e4
  • 1.49e4
  • 1.49e4
50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
UBERON:2007029hindbrain neural keel
  • ZFS:0000022Gastrula:Bud
1.49e4
  • 1.49e4
50.00
  • 50.00
AEIR
  • AEIR
UBERON:2007036hindbrain neural rod
  • ZFS:0000024Segmentation:5-9 somites
1.49e4
  • 1.49e4
50.00
  • 50.00
AEIR
  • AEIR
UBERON:2007045midbrain hindbrain boundary neural keel
  • ZFS:0000022Gastrula:Bud
1.49e4
  • 1.49e4
50.00
  • 50.00
AEIR
  • AEIR
UBERON:0009615midbrain hindbrain boundary neural plate
  • ZFS:0000021Gastrula:90%-epiboly
1.49e4
  • 1.49e4
49.99
  • 49.99
AEIR
  • AEIR
UBERON:2007042spinal cord neural tube
  • ZFS:0000026Segmentation:14-19 somites
1.49e4
  • 1.49e4
49.99
  • 49.99
AEIR
  • AEIR
UBERON:0000014zone of skin
  • UBERON:0000066fully formed stage
1.65e4
  • 1.65e4
44.84
  • 44.84
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
  • Affymetrix data: Bgee
  • EST data: Bgee
  • In situ hybridization data: ZFIN
  • RNA-Seq data: Bgee
Sources of raw data:

Orthologs

Paralogs (same species)

Taxon nameGene(s)Expression comparisonSee details
Euteleostomi1 geneCompare expression

Paralogy information comes from OMA : ENSDARG00000020708.

Cross-references

EnsemblENSDARG00000020708 (mdkb)
ZFINZDB-GENE-010131-6 (mdkb)
EMBLAY008836, CU181898
Uniprot/SPTREMBLQ9DDG2, Q9DDG2_DANRE

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