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D. rerio Gene: top2a - ENSDARG00000024488 - Danio rerio (zebrafish)

General information

Ensembl IDENSDARG00000024488
Nametop2a
Descriptiontopoisomerase (DNA) II alpha [Source:ZFIN;Acc:ZDB-GENE-030131-2453]
OrganismDanio rerio (zebrafish)
Synonym(s)f1r4t2, fc08c07, wu:fc08c07
Orthologs(s)7 orthologs
Paralog(s)1 paralogs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0019248early embryo
  • UBERON:0000107cleavage stage
239
  • 239
99.20
  • 99.20
AEIR
  • AEIR
UBERON:0000473testis
  • UBERON:0000066fully formed stage
493
  • 493
98.35
  • 98.35
AEIR
  • AEIR
UBERON:0000992female gonad
  • UBERON:0000066fully formed stage
632
  • 632
97.89
  • 97.89
AEIR
  • AEIR
UBERON:0000970eye
  • ZFS:0000031Pharyngula:Prim-25
713
  • 713
97.62
  • 97.62
AEIR
  • AEIR
UBERON:0000922embryo
  • UBERON:0004707pharyngula stage
  • UBERON:0000068embryo stage
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000037Larval:Day 5
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000026Segmentation:14-19 somites
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000025Segmentation:10-13 somites
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000031Pharyngula:Prim-25
832
  • 832
  • 1.04e3
  • 3.34e3
  • 3.49e3
  • 3.72e3
  • 7.19e3
  • 8.10e3
  • 8.26e3
  • 9.74e3
  • 1.19e4
97.22
  • 97.22
  • 96.51
  • 88.81
  • 88.31
  • 87.56
  • 75.94
  • 72.89
  • 72.35
  • 67.38
  • 60.24
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002415tail
  • UBERON:0000066fully formed stage
1.06e3
  • 1.06e3
96.46
  • 96.46
AEIR
  • AEIR
UBERON:0003982mature ovarian follicle
  • UBERON:0000066fully formed stage
1.28e3
  • 1.28e3
95.72
  • 95.72
AEIR
  • AEIR
UBERON:0002113kidney
  • UBERON:0000066fully formed stage
1.54e3
  • 1.54e3
94.84
  • 94.84
AEIR
  • AEIR
CL:0000094granulocyte
  • UBERON:0000066fully formed stage
1.66e3
  • 1.66e3
94.44
  • 94.44
AEIR
  • AEIR
UBERON:0000948heart
  • ZFS:0000036Larval:Day 4
  • UBERON:0000066fully formed stage
1.95e3
  • 1.95e3
  • 1.49e4
93.47
  • 93.47
  • 50.19
AEIR
  • AEIR
  • AEIR
UBERON:0004734gastrula
  • ZFS:0000019Gastrula:Shield
  • ZFS:0000022Gastrula:Bud
  • ZFS:0000020Gastrula:75%-epiboly
  • ZFS:0000021Gastrula:90%-epiboly
  • ZFS:0000017Gastrula:50%-epiboly
  • UBERON:0000109gastrula stage
2.32e3
  • 2.32e3
  • 3.09e3
  • 8.15e3
  • 9.89e3
  • 9.95e3
  • 1.15e4
92.22
  • 92.22
  • 89.65
  • 72.72
  • 66.88
  • 66.68
  • 61.51
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000033head
  • ZFS:0000037Larval:Day 5
  • ZFS:0000029Pharyngula:Prim-5
  • UBERON:0000066fully formed stage
  • ZFS:0000031Pharyngula:Prim-25
2.96e3
  • 2.96e3
  • 1.12e4
  • 1.48e4
  • 1.49e4
90.10
  • 90.10
  • 62.50
  • 50.38
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002481bone tissue
  • UBERON:0000066fully formed stage
3.02e3
  • 3.02e3
89.88
  • 89.88
AEIR
  • AEIR
UBERON:0000307blastula
  • ZFS:0000015Blastula:Dome
  • ZFS:0000011Blastula:1k-cell
  • ZFS:0000009Blastula:256-cell
  • ZFS:0000014Blastula:Sphere
  • ZFS:0000016Blastula:30%-epiboly
3.22e3
  • 3.22e3
  • 6.25e3
  • 8.59e3
  • 8.72e3
  • 1.14e4
89.21
  • 89.21
  • 79.08
  • 71.24
  • 70.81
  • 61.86
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002385muscle tissue
  • UBERON:0000066fully formed stage
3.84e3
  • 3.84e3
87.16
  • 87.16
AEIR
  • AEIR
UBERON:0000966retina
  • ZFS:0000037Larval:Day 5
  • ZFS:0000031Pharyngula:Prim-25
  • ZFS:0000033Hatching:Long-pec
  • ZFS:0000035Larval:Protruding-mouth
4.19e3
  • 4.19e3
  • 9.75e3
  • 1.01e4
  • 1.39e4
85.96
  • 85.96
  • 67.35
  • 66.03
  • 53.31
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002548larva
  • ZFS:0000037Larval:Day 5
  • UBERON:0000069larval stage
  • ZFS:0000035Larval:Protruding-mouth
5.23e3
  • 5.23e3
  • 9.89e3
  • 1.22e4
82.47
  • 82.47
  • 66.87
  • 59.03
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000468multi-cellular organism
  • ZFS:0000030Pharyngula:Prim-15
  • ZFS:0000033Hatching:Long-pec
  • UBERON:00072368 cell stage
  • ZFS:0000020Gastrula:75%-epiboly
  • ZFS:0000029Pharyngula:Prim-5
  • ZFS:0000021Gastrula:90%-epiboly
  • ZFS:0000024Segmentation:5-9 somites
  • ZFS:0000036Larval:Day 4
  • ZFS:0000019Gastrula:Shield
  • ZFS:0000026Segmentation:14-19 somites
  • UBERON:0000106zygote stage
  • ZFS:0000022Gastrula:Bud
  • ZFS:0000037Larval:Day 5
  • ZFS:0000040Larval:Days 14-20
  • ZFS:0000042Juvenile:Days 30-44
  • UBERON:0000104life cycle
  • UBERON:0000066fully formed stage
  • UBERON:0000068embryo stage
5.36e3
  • 5.36e3
  • 6.63e3
  • 6.79e3
  • 7.06e3
  • 7.09e3
  • 7.44e3
  • 8.15e3
  • 8.25e3
  • 8.53e3
  • 8.60e3
  • 9.29e3
  • 9.30e3
  • 9.45e3
  • 9.61e3
  • 9.89e3
  • 1.41e4
  • 1.46e4
  • 1.50e4
82.06
  • 82.06
  • 77.79
  • 77.27
  • 76.36
  • 76.27
  • 75.09
  • 72.72
  • 72.36
  • 71.45
  • 71.22
  • 68.90
  • 68.86
  • 68.35
  • 67.81
  • 66.89
  • 52.86
  • 51.12
  • 49.80
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0007132head kidney
  • UBERON:0000066fully formed stage
6.35e3
  • 6.35e3
78.72
  • 78.72
AEIR
  • AEIR
UBERON:0000160intestine
  • UBERON:0000066fully formed stage
6.89e3
  • 6.89e3
76.94
  • 76.94
AEIR
  • AEIR
UBERON:0009620tail bud paraxial mesoderm
  • ZFS:0000027Segmentation:20-25 somites
8.07e3
  • 8.07e3
72.97
  • 72.97
AEIR
  • AEIR
UBERON:0002199integument
  • UBERON:0000066fully formed stage
8.39e3
  • 8.39e3
71.90
  • 71.90
AEIR
  • AEIR
UBERON:0003077paraxial mesoderm
  • ZFS:0000025Segmentation:10-13 somites
8.63e3
  • 8.63e3
71.10
  • 71.10
AEIR
  • AEIR
UBERON:0000206pharyngeal gill
  • UBERON:0000066fully formed stage
8.65e3
  • 8.65e3
71.05
  • 71.05
AEIR
  • AEIR
UBERON:0000014zone of skin
  • UBERON:0000066fully formed stage
8.86e3
  • 8.86e3
70.33
  • 70.33
AEIR
  • AEIR
UBERON:0002106spleen
  • UBERON:0000066fully formed stage
8.92e3
  • 8.92e3
70.12
  • 70.12
AEIR
  • AEIR
UBERON:0000955brain
  • ZFS:0000031Pharyngula:Prim-25
  • UBERON:0000066fully formed stage
8.98e3
  • 8.98e3
  • 1.57e4
69.93
  • 69.93
  • 47.36
AEIR
  • AEIR
  • AEIR
UBERON:0002329somite
  • ZFS:0000025Segmentation:10-13 somites
9.25e3
  • 9.25e3
69.03
  • 69.03
AEIR
  • AEIR
UBERON:0006860swim bladder
  • UBERON:0000066fully formed stage
9.61e3
  • 9.61e3
67.83
  • 67.83
AEIR
  • AEIR
UBERON:0003059presomitic mesoderm
  • ZFS:0000025Segmentation:10-13 somites
9.75e3
  • 9.75e3
67.36
  • 67.36
AEIR
  • AEIR
UBERON:0007010cleaving embryo
  • ZFS:0000005Cleavage:16-cell
1.02e4
  • 1.02e4
65.83
  • 65.83
AEIR
  • AEIR
UBERON:4000164caudal fin
  • ZFS:0000033Hatching:Long-pec
  • UBERON:0000066fully formed stage
1.08e4
  • 1.08e4
  • 1.23e4
63.70
  • 63.70
  • 58.93
AEIR
  • AEIR
  • AEIR
UBERON:0001555digestive tract
  • ZFS:0000035Larval:Protruding-mouth
1.12e4
  • 1.12e4
62.49
  • 62.49
AEIR
  • AEIR
UBERON:0000151pectoral fin
  • ZFS:0000035Larval:Protruding-mouth
1.28e4
  • 1.28e4
57.14
  • 57.14
AEIR
  • AEIR
UBERON:0001264pancreas
  • ZFS:0000035Larval:Protruding-mouth
1.28e4
  • 1.28e4
57.14
  • 57.14
AEIR
  • AEIR
UBERON:0002107liver
  • ZFS:0000035Larval:Protruding-mouth
  • UBERON:0000066fully formed stage
1.28e4
  • 1.28e4
  • 1.38e4
57.13
  • 57.13
  • 53.69
AEIR
  • AEIR
  • AEIR
UBERON:0001049neural tube
  • ZFS:0000029Pharyngula:Prim-5
1.30e4
  • 1.30e4
56.49
  • 56.49
AEIR
  • AEIR
UBERON:0001891midbrain
  • ZFS:0000035Larval:Protruding-mouth
1.34e4
  • 1.34e4
54.99
  • 54.99
AEIR
  • AEIR
UBERON:0001945superior colliculus
  • ZFS:0000035Larval:Protruding-mouth
1.37e4
  • 1.37e4
54.15
  • 54.15
AEIR
  • AEIR
UBERON:0002028hindbrain
  • ZFS:0000035Larval:Protruding-mouth
1.39e4
  • 1.39e4
53.55
  • 53.55
AEIR
  • AEIR
UBERON:0001630muscle organ
  • UBERON:0000066fully formed stage
1.49e4
  • 1.49e4
50.11
  • 50.11
AEIR
  • AEIR
UBERON:0008896post-hyoid pharyngeal arch
  • ZFS:0000035Larval:Protruding-mouth
1.49e4
  • 1.49e4
50.00
  • 50.00
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
  • Affymetrix data: Bgee
  • EST data: Bgee
  • In situ hybridization data: ZFIN
  • RNA-Seq data: Bgee
Sources of raw data:

Orthologs

Orthology information comes from OMA : ENSDARG00000024488.

Paralogs (same species)

Taxon nameGene(s)Expression comparisonSee details
Chordata1 geneCompare expression

Paralogy information comes from OMA : ENSDARG00000024488.

Cross-references

EnsemblENSDARG00000024488 (top2a)
ZFINZDB-GENE-030131-2453 (top2a)
EMBLBX470262
Uniprot/SPTREMBLA8E7K3, A8E7K3_DANRE

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