Gene: fzd8a - ENSDARG00000045444 - Danio rerio (zebrafish)

General information

Ensembl ID	ENSDARG00000045444
Name	fzd8a
Description	frizzled class receptor 8a [Source:ZFIN;Acc:ZDB-GENE-000328-3]
Organism	Danio rerio (zebrafish)
Synonym(s)	fz5, fz8a, fzc, wu:fd02c05, zfzc, zg05
Orthologs(s)	18 orthologs
Paralog(s)	10 paralogs

Expression

Anat. entity ID	Anatomical entity	Developmental stage(s)	Rank score	Expression score	Sources
UBERON:0000948	heart	[+] 3 stages ZFS:0000035Larval:Protruding-mouth ZFS:0000036Larval:Day 4 UBERON:0000066fully formed stage	2.30e3 2.30e3 4.12e3 1.44e4	92.31 92.31 86.20 51.70	AEIR AEIR AEIR AEIR
UBERON:0004734	gastrula	[+] 6 stages ZFS:0000020Gastrula:75%-epiboly ZFS:0000022Gastrula:Bud UBERON:0000109gastrula stage ZFS:0000021Gastrula:90%-epiboly ZFS:0000017Gastrula:50%-epiboly ZFS:0000019Gastrula:Shield	3.12e3 3.12e3 3.46e3 3.49e3 3.69e3 3.98e3 4.37e3	89.54 89.54 88.41 88.32 87.64 86.67 85.36	AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0000468	multi-cellular organism	[+] 16 stages ZFS:0000020Gastrula:75%-epiboly ZFS:0000021Gastrula:90%-epiboly ZFS:0000022Gastrula:Bud ZFS:0000019Gastrula:Shield ZFS:0000030Pharyngula:Prim-15 ZFS:0000033Hatching:Long-pec ZFS:0000029Pharyngula:Prim-5 ZFS:0000026Segmentation:14-19 somites ZFS:0000036Larval:Day 4 ZFS:0000024Segmentation:5-9 somites ZFS:0000037Larval:Day 5 ZFS:0000042Juvenile:Days 30-44 ZFS:0000040Larval:Days 14-20 UBERON:0000104life cycle UBERON:0000066fully formed stage UBERON:0000068embryo stage	3.16e3 3.16e3 3.22e3 3.62e3 4.03e3 4.30e3 4.78e3 4.91e3 5.12e3 5.20e3 5.78e3 5.86e3 7.01e3 7.44e3 1.47e4 1.49e4 1.49e4	89.43 89.43 89.23 87.88 86.51 85.59 83.98 83.57 82.87 82.60 80.65 80.39 76.54 75.07 50.90 50.25 50.20	AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0002106	spleen	[+] 1 stage UBERON:0000066fully formed stage	3.28e3 3.28e3	89.03 89.03	AEIR AEIR
UBERON:0003053	ventricular zone	[+] 4 stages ZFS:0000030Pharyngula:Prim-15 ZFS:0000031Pharyngula:Prim-25 ZFS:0000033Hatching:Long-pec ZFS:0000032Pharyngula:High-pec	3.73e3 3.73e3 3.73e3 6.89e3 7.47e3	87.50 87.50 87.50 76.92 74.99	AEIR AEIR AEIR AEIR AEIR
UBERON:0000160	intestine	[+] 1 stage UBERON:0000066fully formed stage	3.99e3 3.99e3	86.65 86.65	AEIR AEIR
UBERON:0000922	embryo	[+] 10 stages ZFS:0000029Pharyngula:Prim-5 ZFS:0000030Pharyngula:Prim-15 UBERON:0004707pharyngula stage ZFS:0000031Pharyngula:Prim-25 UBERON:0000068embryo stage ZFS:0000024Segmentation:5-9 somites ZFS:0000026Segmentation:14-19 somites ZFS:0000025Segmentation:10-13 somites ZFS:0000033Hatching:Long-pec ZFS:0000037Larval:Day 5	4.00e3 4.00e3 4.33e3 4.52e3 4.56e3 5.58e3 5.75e3 6.10e3 6.21e3 6.57e3 9.01e3	86.60 86.60 85.50 84.87 84.75 81.30 80.73 79.56 79.21 78.02 69.84	AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0001890	forebrain	[+] 8 stages ZFS:0000030Pharyngula:Prim-15 ZFS:0000031Pharyngula:Prim-25 ZFS:0000026Segmentation:14-19 somites ZFS:0000027Segmentation:20-25 somites ZFS:0000028Segmentation:26+ somites ZFS:0000029Pharyngula:Prim-5 ZFS:0000033Hatching:Long-pec ZFS:0000032Pharyngula:High-pec	4.60e3 4.60e3 4.60e3 6.97e3 7.91e3 7.91e3 8.30e3 8.96e3 9.60e3	84.61 84.61 84.61 76.66 73.52 73.52 72.21 69.99 67.85	AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0002240	spinal cord	[+] 7 stages ZFS:0000031Pharyngula:Prim-25 ZFS:0000030Pharyngula:Prim-15 ZFS:0000027Segmentation:20-25 somites ZFS:0000028Segmentation:26+ somites ZFS:0000029Pharyngula:Prim-5 ZFS:0000033Hatching:Long-pec ZFS:0000032Pharyngula:High-pec	4.75e3 4.75e3 6.11e3 7.47e3 7.47e3 7.47e3 8.65e3 9.67e3	84.08 84.08 79.53 74.99 74.99 74.98 71.04 67.63	AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0002548	larva	[+] 3 stages ZFS:0000037Larval:Day 5 ZFS:0000035Larval:Protruding-mouth UBERON:0000069larval stage	5.19e3 5.19e3 5.78e3 6.01e3	82.62 82.62 80.66 79.89	AEIR AEIR AEIR AEIR
UBERON:0002028	hindbrain	[+] 8 stages ZFS:0000031Pharyngula:Prim-25 ZFS:0000030Pharyngula:Prim-15 ZFS:0000027Segmentation:20-25 somites ZFS:0000028Segmentation:26+ somites ZFS:0000029Pharyngula:Prim-5 ZFS:0000026Segmentation:14-19 somites ZFS:0000033Hatching:Long-pec ZFS:0000032Pharyngula:High-pec	5.20e3 5.20e3 5.98e3 6.40e3 6.72e3 8.01e3 9.71e3 9.71e3 1.02e4	82.60 82.60 79.99 78.56 77.49 73.19 67.48 67.48 65.77	AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0000970	eye	[+] 1 stage ZFS:0000031Pharyngula:Prim-25	5.98e3 5.98e3	79.99 79.99	AEIR AEIR
UBERON:0002107	liver	[+] 2 stages UBERON:0000066fully formed stage ZFS:0000033Hatching:Long-pec	6.01e3 6.01e3 1.35e4	79.87 79.87 54.73	AEIR AEIR AEIR
UBERON:0000966	retina	[+] 2 stages ZFS:0000031Pharyngula:Prim-25 ZFS:0000033Hatching:Long-pec	6.07e3 6.07e3 8.63e3	79.68 79.68 71.12	AEIR AEIR AEIR
UBERON:0005886	post-hyoid pharyngeal arch skeleton	[+] 8 stages ZFS:0000030Pharyngula:Prim-15 ZFS:0000031Pharyngula:Prim-25 ZFS:0000026Segmentation:14-19 somites ZFS:0000027Segmentation:20-25 somites ZFS:0000028Segmentation:26+ somites ZFS:0000029Pharyngula:Prim-5 ZFS:0000032Pharyngula:High-pec ZFS:0000033Hatching:Long-pec	6.29e3 6.29e3 6.29e3 8.04e3 8.22e3 8.22e3 8.54e3 9.67e3 9.67e3	78.94 78.94 78.94 73.07 72.48 72.48 71.41 67.63 67.63	AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0001891	midbrain	[+] 4 stages ZFS:0000028Segmentation:26+ somites ZFS:0000027Segmentation:20-25 somites ZFS:0000029Pharyngula:Prim-5 ZFS:0000033Hatching:Long-pec	6.54e3 6.54e3 6.64e3 8.22e3 1.29e4	78.12 78.12 77.77 72.48 56.65	AEIR AEIR AEIR AEIR AEIR
UBERON:0000307	blastula	[+] 3 stages ZFS:0000016Blastula:30%-epiboly ZFS:0000015Blastula:Dome ZFS:0000014Blastula:Sphere	6.86e3 6.86e3 8.20e3 1.03e4	77.04 77.04 72.54 65.66	AEIR AEIR AEIR AEIR
UBERON:0001049	neural tube	[+] 4 stages ZFS:0000029Pharyngula:Prim-5 ZFS:0000027Segmentation:20-25 somites ZFS:0000028Segmentation:26+ somites ZFS:0000026Segmentation:14-19 somites	7.15e3 7.15e3 7.47e3 7.47e3 8.96e3	76.07 76.07 74.99 74.99 69.98	AEIR AEIR AEIR AEIR AEIR
UBERON:2001470	anterior lateral line	[+] 3 stages ZFS:0000033Hatching:Long-pec ZFS:0000035Larval:Protruding-mouth ZFS:0000036Larval:Day 4	7.47e3 7.47e3 7.47e3 1.49e4	75.00 75.00 75.00 50.00	AEIR AEIR AEIR AEIR
UBERON:0002539	pharyngeal arch	[+] 3 stages ZFS:0000036Larval:Day 4 ZFS:0000035Larval:Protruding-mouth ZFS:0000033Hatching:Long-pec	7.47e3 7.47e3 9.51e3 1.21e4	75.00 75.00 68.17 59.36	AEIR AEIR AEIR AEIR
UBERON:0008904	neuromast	[+] 1 stage ZFS:0000037Larval:Day 5	7.47e3 7.47e3	75.00 75.00	AEIR AEIR
UBERON:0000955	brain	[+] 2 stages ZFS:0000031Pharyngula:Prim-25 UBERON:0000066fully formed stage	7.52e3 7.52e3 1.15e4	74.82 74.82 61.57	AEIR AEIR AEIR
UBERON:4000164	caudal fin	[+] 2 stages ZFS:0000033Hatching:Long-pec UBERON:0000066fully formed stage	8.26e3 8.26e3 1.22e4	72.34 72.34 59.07	AEIR AEIR AEIR
UBERON:2000083	ventral mesoderm	[+] 1 stage ZFS:0000026Segmentation:14-19 somites	8.79e3 8.79e3	70.57 70.57	AEIR AEIR
UBERON:0002199	integument	[+] 1 stage UBERON:0000066fully formed stage	8.84e3 8.84e3	70.41 70.41	AEIR AEIR
UBERON:0004117	pharyngeal pouch	[+] 2 stages ZFS:0000029Pharyngula:Prim-5 ZFS:0000030Pharyngula:Prim-15	8.96e3 8.96e3 1.49e4	70.00 70.00 50.00	AEIR AEIR AEIR
UBERON:0002082	cardiac ventricle	[+] 1 stage UBERON:0000066fully formed stage	9.52e3 9.52e3	68.11 68.11	AEIR AEIR
UBERON:0001630	muscle organ	[+] 1 stage UBERON:0000066fully formed stage	9.78e3 9.78e3	67.26 67.26	AEIR AEIR
UBERON:0003059	presomitic mesoderm	[+] 1 stage ZFS:0000025Segmentation:10-13 somites	9.79e3 9.79e3	67.23 67.23	AEIR AEIR
UBERON:0006222	future diencephalon	[+] 3 stages ZFS:0000023Segmentation:1-4 somites ZFS:0000025Segmentation:10-13 somites ZFS:0000024Segmentation:5-9 somites	9.96e3 9.96e3 9.96e3 1.03e4	66.66 66.66 66.66 65.37	AEIR AEIR AEIR AEIR
UBERON:0014371	future telencephalon	[+] 3 stages ZFS:0000025Segmentation:10-13 somites ZFS:0000024Segmentation:5-9 somites ZFS:0000023Segmentation:1-4 somites	1.03e4 1.03e4 1.07e4 1.12e4	65.37 65.37 64.27 62.49	AEIR AEIR AEIR AEIR
UBERON:0000033	head	[+] 2 stages ZFS:0000037Larval:Day 5 UBERON:0000066fully formed stage	1.06e4 1.06e4 1.94e4	64.51 64.51 35.21	AEIR AEIR AEIR
UBERON:0009620	tail bud paraxial mesoderm	[+] 1 stage ZFS:0000027Segmentation:20-25 somites	1.07e4 1.07e4	64.28 64.28	AEIR AEIR
UBERON:0002264	olfactory bulb	[+] 1 stage ZFS:0000035Larval:Protruding-mouth	1.12e4 1.12e4	62.50 62.50	AEIR AEIR
UBERON:0002346	neurectoderm	[+] 3 stages ZFS:0000023Segmentation:1-4 somites ZFS:0000022Gastrula:Bud ZFS:0000025Segmentation:10-13 somites	1.12e4 1.12e4 1.24e4 1.49e4	62.50 62.50 58.33 50.00	AEIR AEIR AEIR AEIR
UBERON:0003351	pharyngeal epithelium	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.12e4 1.12e4	62.50 62.50	AEIR AEIR
UBERON:0007132	head kidney	[+] 1 stage UBERON:0000066fully formed stage	1.13e4 1.13e4	62.24 62.24	AEIR AEIR
UBERON:0006860	swim bladder	[+] 1 stage UBERON:0000066fully formed stage	1.14e4 1.14e4	61.79 61.79	AEIR AEIR
UBERON:0002329	somite	[+] 1 stage ZFS:0000025Segmentation:10-13 somites	1.15e4 1.15e4	61.46 61.46	AEIR AEIR
UBERON:2000004	anterior axial hypoblast	[+] 6 stages ZFS:0000017Gastrula:50%-epiboly ZFS:0000018Gastrula:Germ-ring ZFS:0000019Gastrula:Shield ZFS:0000021Gastrula:90%-epiboly ZFS:0000022Gastrula:Bud ZFS:0000020Gastrula:75%-epiboly	1.17e4 1.17e4 1.17e4 1.17e4 1.17e4 1.17e4 1.20e4	60.70 60.70 60.70 60.70 60.70 60.70 59.98	AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0001846	internal ear	[+] 2 stages ZFS:0000035Larval:Protruding-mouth ZFS:0000033Hatching:Long-pec	1.19e4 1.19e4 1.33e4	60.00 60.00 55.55	AEIR AEIR AEIR
UBERON:0000151	pectoral fin	[+] 2 stages ZFS:0000033Hatching:Long-pec ZFS:0000035Larval:Protruding-mouth	1.21e4 1.21e4 1.28e4	59.36 59.36 57.14	AEIR AEIR AEIR
UBERON:0000007	pituitary gland	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.24e4 1.24e4	58.32 58.32	AEIR AEIR
UBERON:0003075	neural plate	[+] 7 stages ZFS:0000017Gastrula:50%-epiboly ZFS:0000018Gastrula:Germ-ring ZFS:0000019Gastrula:Shield ZFS:0000020Gastrula:75%-epiboly ZFS:0000021Gastrula:90%-epiboly ZFS:0000022Gastrula:Bud ZFS:0000023Segmentation:1-4 somites	1.26e4 1.26e4 1.26e4 1.26e4 1.26e4 1.26e4 1.29e4 1.42e4	57.68 57.68 57.68 57.68 57.68 57.68 56.65 52.35	AEIR AEIR AEIR AEIR AEIR AEIR AEIR AEIR
UBERON:0003063	prechordal plate	[+] 4 stages ZFS:0000022Gastrula:Bud ZFS:0000023Segmentation:1-4 somites ZFS:0000024Segmentation:5-9 somites ZFS:0000025Segmentation:10-13 somites	1.28e4 1.28e4 1.28e4 1.28e4 1.49e4	57.14 57.14 57.14 57.14 49.99	AEIR AEIR AEIR AEIR AEIR
UBERON:0005721	pronephric mesoderm	[+] 1 stage ZFS:0000024Segmentation:5-9 somites	1.33e4 1.33e4	55.55 55.55	AEIR AEIR
UBERON:0001893	telencephalon	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.33e4 1.33e4	55.53 55.53	AEIR AEIR
UBERON:0003051	ear vesicle	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.34e4 1.34e4	54.97 54.97	AEIR AEIR
UBERON:0003082	myotome	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.34e4 1.34e4	54.97 54.97	AEIR AEIR
UBERON:0002385	muscle tissue	[+] 1 stage UBERON:0000066fully formed stage	1.36e4 1.36e4	54.39 54.39	AEIR AEIR
UBERON:0001898	hypothalamus	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.39e4 1.39e4	53.55 53.55	AEIR AEIR
UBERON:2007026	forebrain neural keel	[+] 1 stage ZFS:0000023Segmentation:1-4 somites	1.39e4 1.39e4	53.55 53.55	AEIR AEIR
UBERON:0001943	midbrain tegmentum	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.40e4 1.40e4	53.10 53.10	AEIR AEIR
UBERON:0002481	bone tissue	[+] 1 stage UBERON:0000066fully formed stage	1.47e4 1.47e4	50.68 50.68	AEIR AEIR
CL:0000133	neurectodermal cell	[+] 2 stages ZFS:0000029Pharyngula:Prim-5 ZFS:0000031Pharyngula:Prim-25	1.49e4 1.49e4 1.49e4	50.00 50.00 50.00	AEIR AEIR AEIR
UBERON:0006334	posterior lateral line	[+] 3 stages ZFS:0000033Hatching:Long-pec ZFS:0000035Larval:Protruding-mouth ZFS:0000036Larval:Day 4	1.49e4 1.49e4 1.49e4 1.49e4	50.00 50.00 50.00 50.00	AEIR AEIR AEIR AEIR
UBERON:0007390	pectoral appendage cartilage tissue	[+] 1 stage ZFS:0000033Hatching:Long-pec	1.49e4 1.49e4	49.99 49.99	AEIR AEIR
UBERON:0000206	pharyngeal gill	[+] 1 stage UBERON:0000066fully formed stage	1.51e4 1.51e4	49.46 49.46	AEIR AEIR
UBERON:0000014	zone of skin	[+] 1 stage UBERON:0000066fully formed stage	1.73e4 1.73e4	41.91 41.91	AEIR AEIR
UBERON:0019248	early embryo	[+] 1 stage UBERON:0000107cleavage stage	1.78e4 1.78e4	40.28 40.28	AEIR AEIR
UBERON:0000473	testis	[+] 1 stage UBERON:0000066fully formed stage	1.87e4 1.87e4	37.30 37.30	AEIR AEIR

Sources
A	Affymetrix
E	EST
I	In Situ
R	RNA-Seq

data

no data

Rank scores
3.25e4	lightgrey: low confidence scores
	important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:

Affymetrix data: Bgee
EST data: Bgee
In situ hybridization data: ZFIN
RNA-Seq data: Bgee

Sources of raw data:

Affymetrix data: ArrayExpress, GEO
EST data: UniGene
In situ hybridization data: ZFIN
RNA-Seq data: GEO

Orthologs

Taxon name	Species with orthologs	Gene(s)	Expression comparison	See details
Euteleostomi	11 species Homo sapiens (human) Mus musculus (mouse) Pan troglodytes (chimpanzee) Macaca mulatta (macaque) Rattus norvegicus (rat) Bos taurus (cattle) Canis lupus familiaris (dog) Felis catus (cat) Monodelphis domestica (opossum) Anolis carolinensis (green anole) Xenopus tropicalis (western clawed frog)	11 genes ENSG00000177283 FZD8 ENSMUSG00000036904 Fzd8 ENSPTRG00000029908 FZD8 ENSMMUG00000001694 FZD8 ENSRNOG00000059244 LOC100909849 ENSBTAG00000015072 FZD8 ENSCAFG00000003672 FZD8 ENSFCAG00000029299 FZD8 ENSMODG00000006737 FZD8 ENSACAG00000001137 FZD8 ENSXETG00000008812 fzd8	Compare expression	[+]
Bilateria	18 species Homo sapiens (human) Mus musculus (mouse) Drosophila melanogaster (fruit fly) Caenorhabditis elegans (nematode) Pan troglodytes (chimpanzee) Macaca mulatta (macaque) Rattus norvegicus (rat) Bos taurus (cattle) Canis lupus familiaris (dog) Felis catus (cat) Monodelphis domestica (opossum) Anolis carolinensis (green anole) Xenopus tropicalis (western clawed frog) Drosophila ananassae Drosophila mojavensis Drosophila simulans Drosophila virilis Drosophila yakuba	18 genes ENSG00000177283 FZD8 ENSMUSG00000036904 Fzd8 FBgn0016797 fz2 WBGene00000478 cfz-2 ENSPTRG00000029908 FZD8 ENSMMUG00000001694 FZD8 ENSRNOG00000059244 LOC100909849 ENSBTAG00000015072 FZD8 ENSCAFG00000003672 FZD8 ENSFCAG00000029299 FZD8 ENSMODG00000006737 FZD8 ENSACAG00000001137 FZD8 ENSXETG00000008812 fzd8 FBgn0087817 GF10777 FBgn0136218 GI13462 FBgn0184032 GD12297 FBgn0199079 GJ11825 FBgn0240114 GE22913	Compare expression	[+]

Orthology information comes from OMA : ENSDARG00000045444.

Paralogs (same species)

Taxon name	Gene(s)	Expression comparison	See details
Deuterostomia	2 genes ENSDARG00000025420 fzd5 ENSDARG00000038569 fzd8b	Compare expression	[+]
Eumetazoa	10 genes ENSDARG00000014673 fzd9b ENSDARG00000025420 fzd5 ENSDARG00000027589 fzd7b ENSDARG00000035185 fzd9a ENSDARG00000038569 fzd8b ENSDARG00000054438 fzd2 ENSDARG00000060004 fzd7a ENSDARG00000068213 fzd10 ENSDARG00000102815 FZD9 (1 to many) ENSDARG00000104117 fzd4	Compare expression	[+]

Paralogy information comes from OMA : ENSDARG00000045444.

Cross-references

Ensembl	ENSDARG00000045444 (fzd8a)
ZFIN	ZDB-GENE-000328-3 (fzd8a)
EMBL	AF060697, BC056273, BC063227, BX004842
Uniprot/SPTREMBL	Q9YI00, Q9YI00_DANRE