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H. sapiens Gene: IL22 - ENSG00000127318 - Homo sapiens (human)

General information

Ensembl IDENSG00000127318
NameIL22
Descriptioninterleukin 22 [Source:HGNC Symbol;Acc:HGNC:14900]
OrganismHomo sapiens (human)
Synonym(s)il-21, il-22, il-d110, il-tif, iltif, mgc79382, mgc79384, tifa, tifil-23, zcyto18
Orthologs(s)19 orthologs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0001255urinary bladder
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
1.88e4
  • 1.88e4
  • 3.04e4
65.85
  • 65.85
  • 44.76
AEIR
  • AEIR
  • AEIR
UBERON:0001154vermiform appendix
  • UBERON:0000113post-juvenile adult stage
2.08e4
  • 2.08e4
62.20
  • 62.20
AEIR
  • AEIR
UBERON:0002385muscle tissue
  • UBERON:0000104life cycle
2.18e4
  • 2.18e4
60.44
  • 60.44
AEIR
  • AEIR
CL:0000083epithelial cell of pancreas
  • UBERON:0000104life cycle
2.27e4
  • 2.27e4
58.86
  • 58.86
AEIR
  • AEIR
UBERON:0002372tonsil
  • UBERON:0000113post-juvenile adult stage
2.36e4
  • 2.36e4
57.13
  • 57.13
AEIR
  • AEIR
UBERON:0002048lung
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000113post-juvenile adult stage
2.58e4
  • 2.58e4
  • 2.74e4
  • 2.88e4
  • 3.03e4
  • 3.50e4
  • 4.30e4
53.22
  • 53.22
  • 50.23
  • 47.73
  • 44.99
  • 36.51
  • 21.89
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000948heart
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000113post-juvenile adult stage
2.60e4
  • 2.60e4
  • 3.70e4
  • 4.14e4
52.86
  • 52.86
  • 32.78
  • 24.75
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002037cerebellum
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
2.69e4
  • 2.69e4
  • 3.13e4
  • 3.68e4
51.23
  • 51.23
  • 43.18
  • 33.13
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000167oral cavity
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
2.73e4
  • 2.73e4
  • 2.73e4
  • 3.23e4
50.39
  • 50.39
  • 50.37
  • 41.27
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000473testis
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.73e4
  • 2.73e4
  • 3.02e4
  • 3.24e4
  • 3.48e4
  • 3.74e4
50.38
  • 50.38
  • 45.21
  • 41.19
  • 36.82
  • 32.18
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002129cerebellar cortex
  • UBERON:0000104life cycle
2.74e4
  • 2.74e4
50.33
  • 50.33
AEIR
  • AEIR
UBERON:0000995uterus
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
2.75e4
  • 2.75e4
  • 2.95e4
50.06
  • 50.06
  • 46.52
AEIR
  • AEIR
  • AEIR
UBERON:0001976epithelium of esophagus
  • UBERON:0000104life cycle
2.75e4
  • 2.75e4
50.04
  • 50.04
AEIR
  • AEIR
UBERON:0002245cerebellar hemisphere
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000104life cycle
2.81e4
  • 2.81e4
  • 2.96e4
  • 3.10e4
  • 3.22e4
49.06
  • 49.06
  • 46.23
  • 43.62
  • 41.52
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001155colon
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000113post-juvenile adult stage
2.83e4
  • 2.83e4
  • 2.87e4
  • 3.07e4
  • 3.85e4
  • 4.25e4
48.58
  • 48.58
  • 47.87
  • 44.29
  • 30.06
  • 22.77
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000992female gonad
  • HsapDv:0000199fifth LMP month human stage (human)
  • HsapDv:0000197third LMP month human stage (human)
  • UBERON:0000111organogenesis stage
  • HsapDv:0000198fourth LMP month human stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.85e4
  • 2.85e4
  • 3.24e4
  • 3.24e4
  • 3.24e4
  • 3.40e4
  • 3.99e4
48.29
  • 48.29
  • 41.26
  • 41.15
  • 41.11
  • 38.34
  • 27.56
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002108small intestine
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.89e4
  • 2.89e4
  • 2.95e4
  • 4.03e4
47.53
  • 47.53
  • 46.40
  • 26.79
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000355pharyngeal mucosa
  • HsapDv:000009025-44 year-old human stage (human)
2.92e4
  • 2.92e4
46.91
  • 46.91
AEIR
  • AEIR
UBERON:0001296myometrium
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.96e4
  • 2.96e4
  • 3.19e4
  • 4.02e4
  • 4.39e4
46.24
  • 46.24
  • 42.01
  • 27.01
  • 20.22
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002384connective tissue
  • UBERON:0000104life cycle
2.97e4
  • 2.97e4
46.16
  • 46.16
AEIR
  • AEIR
UBERON:0003454small intestine Peyer's patch
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.99e4
  • 2.99e4
  • 3.58e4
  • 3.74e4
45.73
  • 45.73
  • 35.01
  • 32.16
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000945stomach
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
3.02e4
  • 3.02e4
  • 3.30e4
  • 3.93e4
  • 3.98e4
45.23
  • 45.23
  • 40.00
  • 28.60
  • 27.68
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000317colonic mucosa
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
3.03e4
  • 3.03e4
  • 3.08e4
  • 3.22e4
45.05
  • 45.05
  • 44.05
  • 41.49
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006920esophagus squamous epithelium
  • UBERON:0000104life cycle
3.04e4
  • 3.04e4
44.73
  • 44.73
AEIR
  • AEIR
UBERON:0001812palpebral conjunctiva
  • HsapDv:00000856-12 year-old child stage (human)
3.05e4
  • 3.05e4
44.60
  • 44.60
AEIR
  • AEIR
UBERON:0002469esophagus mucosa
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
3.12e4
  • 3.12e4
  • 3.28e4
  • 3.28e4
  • 3.47e4
  • 3.84e4
43.40
  • 43.40
  • 40.49
  • 40.45
  • 36.93
  • 30.35
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000014zone of skin
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000113post-juvenile adult stage
3.13e4
  • 3.13e4
  • 3.17e4
  • 3.24e4
  • 3.80e4
43.12
  • 43.12
  • 42.39
  • 41.13
  • 31.07
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000178blood
  • HsapDv:000009465-79 year-old human stage (human)
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
3.16e4
  • 3.16e4
  • 3.34e4
  • 3.48e4
  • 3.58e4
  • 3.73e4
  • 3.73e4
  • 3.77e4
  • 4.11e4
42.71
  • 42.71
  • 39.44
  • 36.77
  • 34.98
  • 32.36
  • 32.32
  • 31.51
  • 25.40
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001013adipose tissue
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000113post-juvenile adult stage
3.16e4
  • 3.16e4
  • 3.16e4
  • 3.17e4
  • 4.03e4
42.64
  • 42.64
  • 42.57
  • 42.45
  • 26.75
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0007808adipose tissue of abdominal region
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000088human early adulthood stage (human)
3.17e4
  • 3.17e4
  • 3.17e4
  • 3.22e4
42.43
  • 42.43
  • 42.40
  • 41.59
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0003729mouth mucosa
  • UBERON:0000104life cycle
3.17e4
  • 3.17e4
42.39
  • 42.39
AEIR
  • AEIR
UBERON:0001043esophagus
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
3.21e4
  • 3.21e4
  • 3.53e4
  • 4.55e4
  • 4.55e4
41.68
  • 41.68
  • 35.87
  • 17.45
  • 17.43
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002358peritoneum
  • UBERON:0000104life cycle
3.23e4
  • 3.23e4
41.41
  • 41.41
AEIR
  • AEIR
UBERON:0002114duodenum
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
3.23e4
  • 3.23e4
  • 3.25e4
41.27
  • 41.27
  • 40.96
AEIR
  • AEIR
  • AEIR
UBERON:0001044saliva-secreting gland
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
3.24e4
  • 3.24e4
  • 3.54e4
41.26
  • 41.26
  • 35.66
AEIR
  • AEIR
  • AEIR
UBERON:0000996vagina
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
3.27e4
  • 3.27e4
  • 3.92e4
  • 3.95e4
  • 4.05e4
  • 4.07e4
40.66
  • 40.66
  • 28.88
  • 28.28
  • 26.48
  • 26.06
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0010414omental fat pad
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
3.29e4
  • 3.29e4
  • 3.67e4
  • 3.82e4
  • 4.12e4
  • 4.20e4
40.31
  • 40.31
  • 33.40
  • 30.72
  • 25.24
  • 23.74
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001135smooth muscle tissue
  • UBERON:0000113post-juvenile adult stage
3.54e4
  • 3.54e4
35.65
  • 35.65
AEIR
  • AEIR
UBERON:0001830minor salivary gland
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
3.63e4
  • 3.63e4
  • 3.77e4
34.14
  • 34.14
  • 31.54
AEIR
  • AEIR
  • AEIR
UBERON:0004533left testis
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
3.80e4
  • 3.80e4
  • 3.82e4
30.93
  • 30.93
  • 30.62
AEIR
  • AEIR
  • AEIR
UBERON:0001157transverse colon
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
3.81e4
  • 3.81e4
  • 3.91e4
  • 4.25e4
30.84
  • 30.84
  • 28.96
  • 22.90
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001161body of stomach
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
4.07e4
  • 4.07e4
  • 4.26e4
  • 4.28e4
26.12
  • 26.12
  • 22.64
  • 22.20
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006631right atrium auricular region
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
4.08e4
  • 4.08e4
  • 4.10e4
  • 4.48e4
25.99
  • 25.99
  • 25.59
  • 18.68
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001416skin of abdomen
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
4.28e4
  • 4.28e4
  • 4.40e4
22.24
  • 22.24
  • 20.09
AEIR
  • AEIR
  • AEIR
UBERON:0001511skin of leg
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
4.29e4
  • 4.29e4
  • 4.30e4
  • 4.59e4
22.04
  • 22.04
  • 21.91
  • 16.65
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0035841esophagogastric junction muscularis propria
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
4.32e4
  • 4.32e4
  • 4.38e4
  • 4.39e4
  • 4.50e4
21.51
  • 21.51
  • 20.38
  • 20.35
  • 18.20
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002119left ovary
  • HsapDv:0000087human adult stage (human)
4.45e4
  • 4.45e4
19.21
  • 19.21
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
  • Affymetrix data: Bgee
  • RNA-Seq data: Bgee
Sources of raw data:

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
Homininae2 species2 genesCompare expression
Catarrhini3 species3 genesCompare expression
Euarchontoglires7 species8 genesCompare expression
Boreoeutheria13 species14 genesCompare expression
Theria14 species15 genesCompare expression
Mammalia15 species16 genesCompare expression
Amniota17 species18 genesCompare expression
Tetrapoda18 species19 genesCompare expression

Orthology information comes from OMA : ENSG00000127318.

Cross-references

CCDSCCDS8982 (CCDS8982.1)
EnsemblENSG00000127318 (IL22)
HGNCHGNC:14900 (IL22)
EMBLAF279437, AF387519, AJ277247, AJ277248, AY358890, BC066263, BC067510, BC069112, BC069308, BC070261
OncoMXIL22 (IL22)
Uniprot/SWISSPROTIL22_HUMAN, Q9GZX6

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