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H. sapiens Gene: HRH4 - ENSG00000134489 - Homo sapiens (human)

General information

Ensembl IDENSG00000134489
NameHRH4
Descriptionhistamine receptor H4 [Source:HGNC Symbol;Acc:HGNC:17383]
OrganismHomo sapiens (human)
Synonym(s)axor35, b0yj19, b2kj48, bg26, gpcr105, gprv53, h4, h4r, hh4r, q4g0i6, q9gzq0
Orthologs(s)15 orthologs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
CL:0000738leukocyte
  • HsapDv:0000092human middle aged stage (human)
1.40e4
  • 1.40e4
74.57
  • 74.57
AEIR
  • AEIR
UBERON:0002371bone marrow
  • HsapDv:00000842-5 year-old child stage (human)
  • HsapDv:0000086adolescent stage (human)
  • HsapDv:00000856-12 year-old child stage (human)
  • UBERON:0034920infant stage
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
  • UBERON:0034919juvenile stage
1.81e4
  • 1.81e4
  • 1.86e4
  • 1.87e4
  • 2.07e4
  • 2.07e4
  • 2.12e4
  • 3.07e4
  • 3.10e4
67.16
  • 67.16
  • 66.26
  • 66.02
  • 62.43
  • 62.40
  • 61.43
  • 44.30
  • 43.74
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
CL:0000576monocyte
  • UBERON:0000113post-juvenile adult stage
1.84e4
  • 1.84e4
66.66
  • 66.66
AEIR
  • AEIR
UBERON:0001255urinary bladder
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
1.94e4
  • 1.94e4
  • 3.11e4
64.83
  • 64.83
  • 43.54
AEIR
  • AEIR
  • AEIR
UBERON:0000178blood
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • UBERON:0000104life cycle
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000086adolescent stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:00000856-12 year-old child stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
  • UBERON:0034919juvenile stage
  • HsapDv:00000842-5 year-old child stage (human)
2.09e4
  • 2.09e4
  • 2.24e4
  • 2.28e4
  • 2.33e4
  • 2.35e4
  • 2.37e4
  • 2.50e4
  • 2.52e4
  • 2.53e4
  • 2.63e4
  • 2.77e4
  • 2.97e4
  • 3.08e4
61.98
  • 61.98
  • 59.38
  • 58.64
  • 57.70
  • 57.34
  • 57.01
  • 54.59
  • 54.32
  • 54.09
  • 52.20
  • 49.76
  • 46.06
  • 44.06
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002114duodenum
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
2.10e4
  • 2.10e4
  • 3.23e4
61.79
  • 61.79
  • 41.27
AEIR
  • AEIR
  • AEIR
UBERON:0002372tonsil
  • UBERON:0000113post-juvenile adult stage
2.19e4
  • 2.19e4
60.25
  • 60.25
AEIR
  • AEIR
UBERON:0001114right lobe of liver
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.22e4
  • 2.22e4
  • 2.50e4
  • 2.54e4
59.75
  • 59.75
  • 54.63
  • 53.90
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001154vermiform appendix
  • UBERON:0000113post-juvenile adult stage
2.23e4
  • 2.23e4
59.56
  • 59.56
AEIR
  • AEIR
UBERON:0000473testis
  • HsapDv:0000199fifth LMP month human stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000197third LMP month human stage (human)
  • HsapDv:0000198fourth LMP month human stage (human)
2.31e4
  • 2.31e4
  • 2.93e4
  • 3.09e4
  • 3.25e4
57.99
  • 57.99
  • 46.88
  • 43.90
  • 41.07
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001043esophagus
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
2.32e4
  • 2.32e4
  • 2.83e4
  • 3.04e4
  • 3.21e4
57.93
  • 57.93
  • 48.58
  • 44.81
  • 41.68
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000945stomach
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
2.40e4
  • 2.40e4
  • 2.93e4
56.41
  • 56.41
  • 46.88
AEIR
  • AEIR
  • AEIR
UBERON:0001388gastrocnemius
  • UBERON:0000104life cycle
  • HsapDv:0000093human aged stage
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000088human early adulthood stage (human)
2.40e4
  • 2.40e4
  • 2.42e4
  • 2.58e4
  • 2.61e4
  • 2.72e4
  • 2.76e4
56.39
  • 56.39
  • 56.09
  • 53.11
  • 52.60
  • 50.61
  • 49.96
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000948heart
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
2.41e4
  • 2.41e4
  • 2.77e4
  • 2.99e4
  • 3.94e4
56.22
  • 56.22
  • 49.64
  • 45.63
  • 28.49
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002048lung
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000089young adult stage (human)
2.42e4
  • 2.42e4
  • 2.57e4
  • 2.72e4
  • 2.88e4
  • 2.92e4
  • 3.09e4
  • 3.95e4
56.10
  • 56.10
  • 53.29
  • 50.53
  • 47.73
  • 47.01
  • 43.89
  • 28.23
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002385muscle tissue
  • UBERON:0000104life cycle
2.45e4
  • 2.45e4
55.45
  • 55.45
AEIR
  • AEIR
UBERON:0002369adrenal gland
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
2.47e4
  • 2.47e4
  • 2.87e4
  • 3.09e4
55.19
  • 55.19
  • 47.86
  • 43.82
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002106spleen
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000088human early adulthood stage (human)
2.48e4
  • 2.48e4
  • 2.80e4
  • 2.82e4
  • 2.89e4
  • 2.92e4
  • 2.95e4
54.89
  • 54.89
  • 49.17
  • 48.71
  • 47.57
  • 46.89
  • 46.39
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001135smooth muscle tissue
  • UBERON:0000113post-juvenile adult stage
2.52e4
  • 2.52e4
54.17
  • 54.17
AEIR
  • AEIR
UBERON:0013473lower esophagus
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
2.55e4
  • 2.55e4
  • 2.70e4
53.66
  • 53.66
  • 51.06
AEIR
  • AEIR
  • AEIR
UBERON:0001296myometrium
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000113post-juvenile adult stage
2.58e4
  • 2.58e4
  • 2.92e4
  • 2.95e4
  • 2.96e4
  • 3.03e4
  • 3.06e4
  • 3.19e4
53.20
  • 53.20
  • 46.96
  • 46.37
  • 46.21
  • 45.05
  • 44.35
  • 42.01
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000006islet of Langerhans
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
2.60e4
  • 2.60e4
  • 2.61e4
  • 2.73e4
52.86
  • 52.86
  • 52.58
  • 50.49
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002110gall bladder
  • UBERON:0000113post-juvenile adult stage
2.65e4
  • 2.65e4
51.95
  • 51.95
AEIR
  • AEIR
UBERON:0000955brain
  • UBERON:0007220late embryonic stage
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
2.70e4
  • 2.70e4
  • 3.01e4
  • 3.07e4
  • 3.21e4
  • 4.21e4
51.04
  • 51.04
  • 45.34
  • 44.29
  • 41.65
  • 23.63
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001898hypothalamus
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.71e4
  • 2.71e4
  • 2.76e4
  • 3.41e4
  • 3.49e4
50.73
  • 50.73
  • 49.85
  • 38.11
  • 36.57
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0035833lower esophagus muscularis layer
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.73e4
  • 2.73e4
  • 2.75e4
  • 2.75e4
  • 2.82e4
  • 2.91e4
50.49
  • 50.49
  • 50.15
  • 49.98
  • 48.79
  • 47.14
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0035841esophagogastric junction muscularis propria
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
2.78e4
  • 2.78e4
  • 2.84e4
  • 2.88e4
49.53
  • 49.53
  • 48.50
  • 47.62
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002190subcutaneous adipose tissue
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
2.80e4
  • 2.80e4
  • 2.82e4
  • 2.91e4
  • 3.00e4
  • 3.13e4
49.21
  • 49.21
  • 48.75
  • 47.22
  • 45.46
  • 43.22
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001295endometrium
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
2.81e4
  • 2.81e4
  • 3.20e4
48.94
  • 48.94
  • 41.81
AEIR
  • AEIR
  • AEIR
UBERON:0000014zone of skin
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
2.82e4
  • 2.82e4
  • 3.07e4
  • 3.14e4
  • 3.24e4
48.80
  • 48.80
  • 44.29
  • 42.92
  • 41.13
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000996vagina
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
2.85e4
  • 2.85e4
  • 3.05e4
  • 3.08e4
  • 3.10e4
  • 3.22e4
48.26
  • 48.26
  • 44.68
  • 44.09
  • 43.64
  • 41.47
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001893telencephalon
  • HsapDv:0000087human adult stage (human)
2.90e4
  • 2.90e4
47.32
  • 47.32
AEIR
  • AEIR
UBERON:0001323tibial nerve
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
2.91e4
  • 2.91e4
  • 2.92e4
  • 2.94e4
47.19
  • 47.19
  • 47.02
  • 46.68
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0010414omental fat pad
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
2.93e4
  • 2.93e4
  • 2.95e4
  • 2.98e4
46.87
  • 46.87
  • 46.38
  • 45.97
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001511skin of leg
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.94e4
  • 2.94e4
  • 3.00e4
46.56
  • 46.56
  • 45.62
AEIR
  • AEIR
  • AEIR
UBERON:0006631right atrium auricular region
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.95e4
  • 2.95e4
  • 3.01e4
  • 3.09e4
46.53
  • 46.53
  • 45.41
  • 43.97
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002084heart left ventricle
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000104life cycle
3.00e4
  • 3.00e4
  • 3.01e4
  • 3.02e4
  • 3.04e4
45.52
  • 45.52
  • 45.41
  • 45.16
  • 44.89
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001416skin of abdomen
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
3.03e4
  • 3.03e4
  • 3.05e4
  • 3.07e4
44.97
  • 44.97
  • 44.62
  • 44.34
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0035825left adrenal gland cortex
  • HsapDv:0000087human adult stage (human)
3.05e4
  • 3.05e4
44.62
  • 44.62
AEIR
  • AEIR
UBERON:0008952upper lobe of left lung
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
3.07e4
  • 3.07e4
  • 3.13e4
44.32
  • 44.32
  • 43.24
AEIR
  • AEIR
  • AEIR
UBERON:0001874putamen
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
3.08e4
  • 3.08e4
  • 3.24e4
44.07
  • 44.07
  • 41.11
AEIR
  • AEIR
  • AEIR
UBERON:0001890forebrain
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
3.15e4
  • 3.15e4
  • 3.16e4
42.75
  • 42.75
  • 42.57
AEIR
  • AEIR
  • AEIR
UBERON:0000956cerebral cortex
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
  • UBERON:0000113post-juvenile adult stage
3.21e4
  • 3.21e4
  • 3.22e4
  • 3.47e4
41.63
  • 41.63
  • 41.45
  • 37.02
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001870frontal cortex
  • UBERON:0000104life cycle
  • HsapDv:0000089young adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
3.22e4
  • 3.22e4
  • 3.22e4
  • 3.22e4
  • 3.26e4
41.61
  • 41.61
  • 41.58
  • 41.52
  • 40.77
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0008948upper lobe of lung
  • HsapDv:0000089young adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
3.24e4
  • 3.24e4
  • 3.24e4
  • 3.24e4
41.22
  • 41.22
  • 41.19
  • 41.13
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000451prefrontal cortex
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
3.39e4
  • 3.39e4
  • 3.65e4
  • 3.88e4
38.43
  • 38.43
  • 33.72
  • 29.62
AEIR
  • AEIR
  • AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
  • Affymetrix data: Bgee
  • RNA-Seq data: Bgee
Sources of raw data:

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
Homininae2 species2 genesCompare expression
Catarrhini3 species3 genesCompare expression
Euarchontoglires7 species7 genesCompare expression
Boreoeutheria13 species13 genesCompare expression
Theria14 species14 genesCompare expression
Mammalia15 species15 genesCompare expression

Orthology information comes from OMA : ENSG00000134489.

Cross-references

CCDSCCDS11887 (CCDS11887.1), CCDS45841 (CCDS45841.1)
EnsemblENSG00000134489 (HRH4)
HGNCHGNC:17383 (HRH4)
EMBLAB044934, AB045370, AC007922, AF307973, AF312230, AF325356, AF329449, AJ298292, AY136745, BC069136, BC112348, CH471088, DQ835186, EF444982
OncoMXHRH4 (HRH4)
Uniprot/SWISSPROTHRH4_HUMAN, Q9H3N8

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