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H. sapiens Gene: HCRTR2 - ENSG00000137252 - Homo sapiens (human)

General information

Ensembl IDENSG00000137252
NameHCRTR2
Descriptionhypocretin (orexin) receptor 2 [Source:HGNC Symbol;Acc:HGNC:4849]
OrganismHomo sapiens (human)
Synonym(s)ox2r, q5vtm0
Orthologs(s)17 orthologs
Paralog(s)1 paralogs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0005343cortical plate
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
7.24e3
  • 7.24e3
  • 1.17e4
86.85
  • 86.85
  • 78.83
AEIR
  • AEIR
  • AEIR
UBERON:0018303adrenal tissue
  • HsapDv:0000199fifth LMP month human stage (human)
  • HsapDv:0000198fourth LMP month human stage (human)
1.49e4
  • 1.49e4
  • 1.66e4
72.95
  • 72.95
  • 69.88
AEIR
  • AEIR
  • AEIR
UBERON:0001870frontal cortex
  • HsapDv:0000199fifth LMP month human stage (human)
  • UBERON:0034920infant stage
  • HsapDv:000009580 year-old and over human stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000089young adult stage (human)
1.51e4
  • 1.51e4
  • 1.98e4
  • 2.01e4
  • 2.35e4
  • 2.44e4
  • 2.45e4
  • 2.47e4
  • 3.22e4
  • 3.22e4
72.62
  • 72.62
  • 63.99
  • 63.57
  • 57.28
  • 55.62
  • 55.46
  • 55.09
  • 41.61
  • 41.58
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000451prefrontal cortex
  • HsapDv:0000086adolescent stage (human)
  • HsapDv:0000089young adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
1.56e4
  • 1.56e4
  • 1.61e4
  • 2.02e4
  • 2.36e4
  • 2.44e4
  • 2.72e4
71.72
  • 71.72
  • 70.77
  • 63.31
  • 57.15
  • 55.64
  • 50.62
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000956cerebral cortex
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000197third LMP month human stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
1.64e4
  • 1.64e4
  • 1.77e4
  • 2.40e4
  • 3.21e4
  • 3.22e4
  • 3.23e4
70.31
  • 70.31
  • 67.82
  • 56.36
  • 41.63
  • 41.45
  • 41.44
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0003701calcaneal tendon
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000086adolescent stage (human)
1.86e4
  • 1.86e4
  • 1.92e4
  • 2.15e4
66.20
  • 66.20
  • 65.15
  • 60.93
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0013540Brodmann (1909) area 9
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:000009580 year-old and over human stage (human)
2.07e4
  • 2.07e4
  • 2.13e4
  • 2.42e4
  • 2.57e4
62.48
  • 62.48
  • 61.31
  • 56.09
  • 53.35
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001898hypothalamus
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000093human aged stage
2.08e4
  • 2.08e4
  • 2.18e4
  • 2.22e4
  • 2.30e4
  • 2.37e4
  • 2.39e4
  • 2.76e4
  • 2.79e4
62.16
  • 62.16
  • 60.33
  • 59.77
  • 58.26
  • 56.91
  • 56.67
  • 49.85
  • 49.27
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002661superior frontal gyrus
  • UBERON:0000104life cycle
2.09e4
  • 2.09e4
62.12
  • 62.12
AEIR
  • AEIR
UBERON:0001882nucleus accumbens
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000104life cycle
2.21e4
  • 2.21e4
  • 2.69e4
  • 2.71e4
  • 2.87e4
  • 3.10e4
59.86
  • 59.86
  • 51.22
  • 50.84
  • 47.98
  • 43.74
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0009834dorsolateral prefrontal cortex
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000089young adult stage (human)
  • HsapDv:00000856-12 year-old child stage (human)
  • HsapDv:000009580 year-old and over human stage (human)
2.23e4
  • 2.23e4
  • 2.39e4
  • 2.45e4
  • 2.55e4
  • 2.64e4
  • 2.64e4
  • 2.79e4
  • 3.24e4
  • 3.24e4
59.60
  • 59.60
  • 56.60
  • 55.53
  • 53.76
  • 52.13
  • 52.05
  • 49.39
  • 41.26
  • 41.11
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002436primary visual cortex
  • UBERON:0000104life cycle
2.23e4
  • 2.23e4
59.52
  • 59.52
AEIR
  • AEIR
UBERON:0000992female gonad
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
  • HsapDv:0000197third LMP month human stage (human)
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
2.25e4
  • 2.25e4
  • 2.90e4
  • 2.97e4
  • 3.24e4
  • 3.26e4
59.17
  • 59.17
  • 47.37
  • 46.11
  • 41.11
  • 40.74
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000082adult mammalian kidney
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000088human early adulthood stage (human)
2.28e4
  • 2.28e4
  • 2.89e4
  • 2.98e4
  • 3.02e4
  • 3.38e4
  • 4.60e4
58.63
  • 58.63
  • 47.59
  • 45.94
  • 45.20
  • 38.65
  • 16.54
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0007227superior vestibular nucleus
  • HsapDv:000009025-44 year-old human stage (human)
2.35e4
  • 2.35e4
57.34
  • 57.34
AEIR
  • AEIR
UBERON:0006469C1 segment of cervical spinal cord
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.37e4
  • 2.37e4
  • 2.92e4
  • 3.04e4
  • 3.72e4
56.93
  • 56.93
  • 47.07
  • 44.78
  • 32.45
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000473testis
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000089young adult stage (human)
  • HsapDv:000009580 year-old and over human stage (human)
  • UBERON:0000111organogenesis stage
  • HsapDv:0000197third LMP month human stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
2.38e4
  • 2.38e4
  • 2.63e4
  • 2.84e4
  • 2.99e4
  • 3.01e4
  • 3.06e4
  • 3.10e4
  • 3.11e4
  • 3.15e4
  • 3.48e4
56.74
  • 56.74
  • 52.30
  • 48.35
  • 45.65
  • 45.36
  • 44.47
  • 43.78
  • 43.57
  • 42.88
  • 36.82
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001782pigmented layer of retina
  • HsapDv:0000199fifth LMP month human stage (human)
  • HsapDv:0000198fourth LMP month human stage (human)
2.40e4
  • 2.40e4
  • 2.42e4
56.34
  • 56.34
  • 56.03
AEIR
  • AEIR
  • AEIR
UBERON:0000988pons
  • UBERON:0000104life cycle
2.41e4
  • 2.41e4
56.31
  • 56.31
AEIR
  • AEIR
UBERON:0009835anterior cingulate cortex
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.43e4
  • 2.43e4
  • 2.53e4
  • 2.55e4
55.96
  • 55.96
  • 54.02
  • 53.77
AEIR
  • AEIR
  • AEIR
  • AEIR
PBA:294022000subventricular zone (inner) (primate)
  • HsapDv:0000199fifth LMP month human stage (human)
2.47e4
  • 2.47e4
55.12
  • 55.12
AEIR
  • AEIR
UBERON:0001871temporal lobe
  • HsapDv:0000089young adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
2.49e4
  • 2.49e4
  • 3.23e4
54.80
  • 54.80
  • 41.32
AEIR
  • AEIR
  • AEIR
UBERON:0002038substantia nigra
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
2.49e4
  • 2.49e4
  • 2.57e4
  • 2.67e4
  • 2.89e4
  • 2.89e4
  • 3.14e4
54.78
  • 54.78
  • 53.41
  • 51.59
  • 47.50
  • 47.45
  • 42.98
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002810right frontal lobe
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.55e4
  • 2.55e4
  • 2.73e4
  • 2.78e4
53.72
  • 53.72
  • 50.41
  • 49.43
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000948heart
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
2.55e4
  • 2.55e4
  • 2.71e4
  • 2.90e4
  • 3.59e4
53.68
  • 53.68
  • 50.72
  • 47.40
  • 34.83
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001987placenta
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
2.58e4
  • 2.58e4
  • 2.63e4
  • 2.95e4
53.19
  • 53.19
  • 52.17
  • 46.51
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001876amygdala
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000104life cycle
2.59e4
  • 2.59e4
  • 2.71e4
  • 2.73e4
  • 2.79e4
52.94
  • 52.94
  • 50.87
  • 50.34
  • 49.37
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002048lung
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.61e4
  • 2.61e4
  • 2.74e4
  • 2.88e4
  • 3.04e4
  • 3.18e4
52.63
  • 52.63
  • 50.23
  • 47.73
  • 44.85
  • 42.30
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
PBA:294021980subventricular zone (outer) (primate)
  • HsapDv:0000199fifth LMP month human stage (human)
2.62e4
  • 2.62e4
52.34
  • 52.34
AEIR
  • AEIR
UBERON:0006631right atrium auricular region
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.71e4
  • 2.71e4
  • 2.79e4
  • 2.86e4
  • 2.86e4
  • 2.90e4
50.75
  • 50.75
  • 49.31
  • 48.12
  • 48.03
  • 47.41
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001954Ammon's horn
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
  • HsapDv:000009580 year-old and over human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.80e4
  • 2.80e4
  • 2.97e4
  • 2.99e4
  • 3.04e4
  • 3.09e4
  • 3.25e4
  • 3.35e4
49.17
  • 49.17
  • 46.09
  • 45.66
  • 44.89
  • 43.93
  • 41.01
  • 39.24
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000007pituitary gland
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.81e4
  • 2.81e4
  • 3.47e4
  • 3.63e4
  • 3.92e4
49.03
  • 49.03
  • 36.94
  • 34.17
  • 28.91
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002084heart left ventricle
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
2.83e4
  • 2.83e4
  • 2.97e4
  • 3.26e4
  • 3.39e4
  • 3.52e4
  • 3.72e4
48.58
  • 48.58
  • 46.00
  • 40.87
  • 38.42
  • 36.17
  • 32.40
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001891midbrain
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
2.84e4
  • 2.84e4
  • 2.94e4
48.35
  • 48.35
  • 46.64
AEIR
  • AEIR
  • AEIR
UBERON:0001873caudate nucleus
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
3.10e4
  • 3.10e4
  • 3.15e4
  • 3.49e4
  • 3.52e4
43.71
  • 43.71
  • 42.85
  • 36.60
  • 36.14
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002728entorhinal cortex
  • UBERON:0000104life cycle
3.12e4
  • 3.12e4
43.43
  • 43.43
AEIR
  • AEIR
UBERON:0001013adipose tissue
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000113post-juvenile adult stage
3.13e4
  • 3.13e4
  • 3.13e4
  • 3.75e4
43.15
  • 43.15
  • 43.10
  • 31.84
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0007808adipose tissue of abdominal region
  • HsapDv:0000092human middle aged stage (human)
3.13e4
  • 3.13e4
43.15
  • 43.15
AEIR
  • AEIR
UBERON:0003053ventricular zone
  • HsapDv:0000198fourth LMP month human stage (human)
3.20e4
  • 3.20e4
41.92
  • 41.92
AEIR
  • AEIR
UBERON:0002358peritoneum
  • UBERON:0000104life cycle
3.23e4
  • 3.23e4
41.41
  • 41.41
AEIR
  • AEIR
UBERON:0000178blood
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
3.40e4
  • 3.40e4
  • 3.57e4
  • 3.94e4
  • 4.20e4
  • 4.25e4
38.20
  • 38.20
  • 35.21
  • 28.41
  • 23.83
  • 22.85
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0010414omental fat pad
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
3.42e4
  • 3.42e4
  • 3.61e4
  • 3.63e4
37.92
  • 37.92
  • 34.37
  • 34.00
AEIR
  • AEIR
  • AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
Sources of raw data:

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
Homininae2 species2 genesCompare expression
Catarrhini3 species3 genesCompare expression
Euarchontoglires7 species7 genesCompare expression
Boreoeutheria12 species12 genesCompare expression
Theria13 species13 genesCompare expression
Amniota15 species15 genesCompare expression
Tetrapoda16 species16 genesCompare expression
Euteleostomi17 species17 genesCompare expression

Orthology information comes from OMA : ENSG00000137252.

Paralogs (same species)

Taxon nameGene(s)Expression comparisonSee details
Chordata1 geneCompare expression

Paralogy information comes from OMA : ENSG00000137252.

Cross-references

CCDSCCDS4956 (CCDS4956.1)
EnsemblENSG00000137252 (HCRTR2)
HGNCHGNC:4849 (HCRTR2)
EMBLAF041245, AL449104, AL591718, AY062031, CH471081, KC812499
OncoMXHCRTR2 (HCRTR2)
Uniprot/SPTREMBLS4X0W3, S4X0W3_HUMAN
Uniprot/SWISSPROTO43614, OX2R_HUMAN

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