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H. sapiens Gene: CYP2C19 - ENSG00000165841 - Homo sapiens (human)

General information

Ensembl IDENSG00000165841
NameCYP2C19
Descriptioncytochrome P450 family 2 subfamily C member 19 [Source:HGNC Symbol;Acc:HGNC:2621]
OrganismHomo sapiens (human)
Synonym(s)cpcj, cyp2c, cypiic17, cypiic19, p450c2c, p450iic19
Orthologs(s)32 orthologs
Paralog(s)37 paralogs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0002107liver
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • UBERON:0034920infant stage
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
1.62e3
  • 1.62e3
  • 2.37e3
  • 3.20e3
  • 6.05e3
  • 6.60e3
  • 7.29e3
  • 7.54e3
97.06
  • 97.06
  • 95.70
  • 94.19
  • 89.02
  • 88.01
  • 86.77
  • 86.31
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002114duodenum
  • UBERON:0000113post-juvenile adult stage
2.60e3
  • 2.60e3
95.27
  • 95.27
AEIR
  • AEIR
UBERON:0001114right lobe of liver
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
2.67e3
  • 2.67e3
  • 3.27e3
  • 3.62e3
  • 5.80e3
  • 8.10e3
95.16
  • 95.16
  • 94.06
  • 93.43
  • 89.47
  • 85.29
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000160intestine
  • UBERON:0000104life cycle
  • HsapDv:0000199fifth LMP month human stage (human)
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000197third LMP month human stage (human)
3.30e3
  • 3.30e3
  • 7.32e3
  • 7.93e3
  • 1.77e4
94.01
  • 94.01
  • 86.71
  • 85.60
  • 67.92
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000945stomach
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000200sixth LMP month human stage (human)
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0007220late embryonic stage
  • HsapDv:0000197third LMP month human stage (human)
8.95e3
  • 8.95e3
  • 1.22e4
  • 1.32e4
  • 1.43e4
  • 1.60e4
  • 1.61e4
  • 1.81e4
  • 1.96e4
  • 2.07e4
83.75
  • 83.75
  • 77.87
  • 76.11
  • 74.01
  • 70.89
  • 70.73
  • 67.15
  • 64.41
  • 62.45
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0035834lower esophagus mucosa
  • HsapDv:0000091human late adulthood stage (human)
1.24e4
  • 1.24e4
77.53
  • 77.53
AEIR
  • AEIR
UBERON:0003454small intestine Peyer's patch
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
1.24e4
  • 1.24e4
  • 1.28e4
  • 1.41e4
  • 1.66e4
  • 1.77e4
77.49
  • 77.49
  • 76.67
  • 74.33
  • 69.90
  • 67.90
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001155colon
  • HsapDv:0000203ninth LMP month human stage (human)
  • HsapDv:000009580 year-old and over human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000113post-juvenile adult stage
1.37e4
  • 1.37e4
  • 1.86e4
  • 2.52e4
  • 2.64e4
  • 3.25e4
75.20
  • 75.20
  • 66.15
  • 54.17
  • 52.01
  • 40.91
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002110gall bladder
  • UBERON:0000113post-juvenile adult stage
1.60e4
  • 1.60e4
70.92
  • 70.92
AEIR
  • AEIR
UBERON:0002385muscle tissue
  • UBERON:0000104life cycle
1.60e4
  • 1.60e4
70.90
  • 70.90
AEIR
  • AEIR
UBERON:0002469esophagus mucosa
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
1.70e4
  • 1.70e4
  • 1.72e4
  • 1.72e4
  • 1.75e4
  • 1.84e4
  • 1.85e4
69.14
  • 69.14
  • 68.78
  • 68.74
  • 68.17
  • 66.59
  • 66.45
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0012249ectocervix
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
1.77e4
  • 1.77e4
  • 1.96e4
  • 4.00e4
67.78
  • 67.78
  • 64.37
  • 27.44
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001161body of stomach
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
1.99e4
  • 1.99e4
  • 2.45e4
  • 2.49e4
  • 2.55e4
  • 2.57e4
63.96
  • 63.96
  • 55.45
  • 54.71
  • 53.67
  • 53.29
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001199mucosa of stomach
  • HsapDv:0000091human late adulthood stage (human)
1.99e4
  • 1.99e4
63.84
  • 63.84
AEIR
  • AEIR
UBERON:0004991mucosa of transverse colon
  • HsapDv:000009025-44 year-old human stage (human)
2.02e4
  • 2.02e4
63.28
  • 63.28
AEIR
  • AEIR
UBERON:0002113kidney
  • UBERON:0000104life cycle
2.11e4
  • 2.11e4
61.68
  • 61.68
AEIR
  • AEIR
UBERON:0001160fundus of stomach
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.18e4
  • 2.18e4
  • 2.41e4
  • 2.45e4
  • 3.06e4
60.39
  • 60.39
  • 56.31
  • 55.48
  • 44.36
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000996vagina
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.19e4
  • 2.19e4
  • 2.57e4
  • 2.81e4
  • 3.04e4
  • 3.53e4
60.26
  • 60.26
  • 53.34
  • 48.91
  • 44.88
  • 35.89
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001416skin of abdomen
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.56e4
  • 2.56e4
  • 3.04e4
  • 3.08e4
  • 3.13e4
  • 3.15e4
  • 3.41e4
53.49
  • 53.49
  • 44.85
  • 44.01
  • 43.10
  • 42.75
  • 38.04
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001157transverse colon
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.77e4
  • 2.77e4
  • 2.78e4
  • 2.84e4
  • 2.86e4
  • 3.36e4
49.68
  • 49.68
  • 49.59
  • 48.50
  • 48.14
  • 38.92
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001154vermiform appendix
  • UBERON:0000113post-juvenile adult stage
3.00e4
  • 3.00e4
45.45
  • 45.45
AEIR
  • AEIR
UBERON:0000006islet of Langerhans
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
3.04e4
  • 3.04e4
  • 3.37e4
  • 3.71e4
44.87
  • 44.87
  • 38.77
  • 32.72
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001511skin of leg
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000088human early adulthood stage (human)
3.20e4
  • 3.20e4
  • 3.29e4
  • 3.34e4
  • 3.34e4
  • 3.65e4
41.89
  • 41.89
  • 40.21
  • 39.37
  • 39.28
  • 33.69
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001295endometrium
  • HsapDv:0000088human early adulthood stage (human)
  • UBERON:0000113post-juvenile adult stage
3.23e4
  • 3.23e4
  • 3.92e4
41.40
  • 41.40
  • 28.83
AEIR
  • AEIR
  • AEIR
UBERON:0000992female gonad
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
3.32e4
  • 3.32e4
  • 4.35e4
39.80
  • 39.80
  • 21.07
AEIR
  • AEIR
  • AEIR
UBERON:0001830minor salivary gland
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
3.36e4
  • 3.36e4
  • 3.54e4
  • 3.76e4
  • 3.82e4
  • 4.00e4
38.96
  • 38.96
  • 35.66
  • 31.72
  • 30.60
  • 27.45
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001150body of pancreas
  • HsapDv:0000087human adult stage (human)
3.62e4
  • 3.62e4
34.27
  • 34.27
AEIR
  • AEIR
UBERON:0001013adipose tissue
  • UBERON:0000113post-juvenile adult stage
3.71e4
  • 3.71e4
32.64
  • 32.64
AEIR
  • AEIR
UBERON:0000948heart
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000092human middle aged stage (human)
3.72e4
  • 3.72e4
  • 4.38e4
32.49
  • 32.49
  • 20.52
AEIR
  • AEIR
  • AEIR
UBERON:0000451prefrontal cortex
  • HsapDv:0000086adolescent stage (human)
  • UBERON:0000104life cycle
3.76e4
  • 3.76e4
  • 3.81e4
31.68
  • 31.68
  • 30.73
AEIR
  • AEIR
  • AEIR
UBERON:0006469C1 segment of cervical spinal cord
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
3.80e4
  • 3.80e4
  • 3.91e4
  • 3.93e4
31.07
  • 31.07
  • 28.96
  • 28.70
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000178blood
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
3.91e4
  • 3.91e4
  • 3.94e4
  • 3.96e4
  • 4.14e4
  • 4.23e4
29.10
  • 29.10
  • 28.44
  • 28.14
  • 24.83
  • 23.20
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0035833lower esophagus muscularis layer
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
4.03e4
  • 4.03e4
  • 4.15e4
  • 4.22e4
  • 4.37e4
26.83
  • 26.83
  • 24.57
  • 23.32
  • 20.72
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0035805muscle layer of sigmoid colon
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
4.09e4
  • 4.09e4
  • 4.10e4
25.72
  • 25.72
  • 25.51
AEIR
  • AEIR
  • AEIR
UBERON:0035841esophagogastric junction muscularis propria
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
4.14e4
  • 4.14e4
  • 4.18e4
  • 4.40e4
  • 4.43e4
24.82
  • 24.82
  • 24.18
  • 20.16
  • 19.63
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002106spleen
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
4.15e4
  • 4.15e4
  • 4.24e4
  • 4.45e4
  • 4.51e4
24.60
  • 24.60
  • 23.00
  • 19.23
  • 18.04
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006631right atrium auricular region
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
4.17e4
  • 4.17e4
  • 4.31e4
  • 4.33e4
24.28
  • 24.28
  • 21.67
  • 21.30
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002119left ovary
  • HsapDv:0000087human adult stage (human)
4.41e4
  • 4.41e4
19.95
  • 19.95
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
Sources of raw data:

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
Homininae2 species2 genesCompare expression
Euarchontoglires5 species20 genesCompare expression
Amniota7 species32 genesCompare expression

Orthology information comes from OMA : ENSG00000165841.

Paralogs (same species)

Cross-references

CCDSCCDS7436 (CCDS7436.1)
EnsemblENSG00000165841 (CYP2C19)
HGNCHGNC:2621 (CYP2C19)
EMBLAL133513, AL583836, KF459664, KF459665
OncoMXCYP2C19 (CYP2C19)
Uniprot/SPTREMBLA0A087X125, A0A087X125_HUMAN
Uniprot/SWISSPROTCP2CJ_HUMAN, P33261

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