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H. sapiens Gene: GRK1 - ENSG00000185974 - Homo sapiens (human)

General information

Ensembl IDENSG00000185974
NameGRK1
DescriptionG protein-coupled receptor kinase 1 [Source:HGNC Symbol;Acc:HGNC:10013]
OrganismHomo sapiens (human)
Synonym(s)gprk1, q53x14, rhok, rk
Orthologs(s)14 orthologs
Paralog(s)334 paralogs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0001119right lobe of thyroid gland
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
1.28e4
  • 1.28e4
  • 1.40e4
  • 1.43e4
  • 1.52e4
  • 1.55e4
76.75
  • 76.75
  • 74.64
  • 74.12
  • 72.42
  • 71.88
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001120left lobe of thyroid gland
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
1.45e4
  • 1.45e4
  • 1.49e4
  • 1.56e4
  • 1.58e4
  • 1.59e4
  • 1.61e4
73.76
  • 73.76
  • 73.03
  • 71.65
  • 71.32
  • 71.06
  • 70.70
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002046thyroid gland
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
1.45e4
  • 1.45e4
  • 1.64e4
  • 1.67e4
  • 1.67e4
  • 1.82e4
  • 2.01e4
  • 2.62e4
  • 2.86e4
73.64
  • 73.64
  • 70.27
  • 69.72
  • 69.68
  • 66.90
  • 63.54
  • 52.38
  • 48.13
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000006islet of Langerhans
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
1.65e4
  • 1.65e4
  • 3.46e4
70.07
  • 70.07
  • 37.17
AEIR
  • AEIR
  • AEIR
PBA:294021980subventricular zone (outer) (primate)
  • HsapDv:0000198fourth LMP month human stage (human)
2.00e4
  • 2.00e4
63.63
  • 63.63
AEIR
  • AEIR
UBERON:0002098apex of heart
  • HsapDv:0000092human middle aged stage (human)
2.06e4
  • 2.06e4
62.53
  • 62.53
AEIR
  • AEIR
UBERON:0001870frontal cortex
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.07e4
  • 2.07e4
  • 2.50e4
  • 2.50e4
  • 2.90e4
  • 2.92e4
62.45
  • 62.45
  • 54.69
  • 54.59
  • 47.36
  • 46.99
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002084heart left ventricle
  • UBERON:0034920infant stage
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000088human early adulthood stage (human)
2.07e4
  • 2.07e4
  • 2.64e4
  • 2.73e4
  • 2.76e4
  • 2.79e4
  • 2.93e4
  • 3.47e4
62.42
  • 62.42
  • 52.02
  • 50.48
  • 49.84
  • 49.38
  • 46.79
  • 36.92
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001160fundus of stomach
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.11e4
  • 2.11e4
  • 2.81e4
  • 3.18e4
61.71
  • 61.71
  • 48.96
  • 42.29
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002371bone marrow
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.21e4
  • 2.21e4
  • 2.21e4
59.92
  • 59.92
  • 59.89
AEIR
  • AEIR
  • AEIR
UBERON:0002114duodenum
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
2.28e4
  • 2.28e4
  • 2.55e4
58.64
  • 58.64
  • 53.74
AEIR
  • AEIR
  • AEIR
UBERON:0001377quadriceps femoris
  • UBERON:0000104life cycle
  • HsapDv:0000093human aged stage
  • HsapDv:000009465-79 year-old human stage (human)
2.31e4
  • 2.31e4
  • 2.59e4
  • 2.81e4
58.10
  • 58.10
  • 52.91
  • 48.98
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000948heart
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0034920infant stage
  • HsapDv:0000092human middle aged stage (human)
2.31e4
  • 2.31e4
  • 2.35e4
  • 2.45e4
  • 3.78e4
  • 4.01e4
58.00
  • 58.00
  • 57.36
  • 55.43
  • 31.32
  • 27.26
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006631right atrium auricular region
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
2.37e4
  • 2.37e4
  • 2.90e4
  • 2.91e4
  • 2.96e4
  • 3.03e4
56.95
  • 56.95
  • 47.37
  • 47.18
  • 46.25
  • 45.05
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002108small intestine
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
2.37e4
  • 2.37e4
  • 2.56e4
  • 2.89e4
56.89
  • 56.89
  • 53.56
  • 47.53
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001882nucleus accumbens
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.40e4
  • 2.40e4
  • 2.84e4
  • 2.85e4
  • 2.94e4
56.46
  • 56.46
  • 48.37
  • 48.27
  • 46.54
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002048lung
  • HsapDv:0000199fifth LMP month human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0007220late embryonic stage
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.40e4
  • 2.40e4
  • 2.71e4
  • 2.74e4
  • 2.78e4
  • 2.88e4
  • 3.07e4
  • 3.42e4
56.35
  • 56.35
  • 50.73
  • 50.23
  • 49.56
  • 47.73
  • 44.24
  • 37.86
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000451prefrontal cortex
  • HsapDv:0000091human late adulthood stage (human)
  • UBERON:0000104life cycle
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000086adolescent stage (human)
  • HsapDv:0000089young adult stage (human)
2.44e4
  • 2.44e4
  • 2.55e4
  • 2.63e4
  • 2.63e4
  • 2.78e4
55.72
  • 55.72
  • 53.66
  • 52.33
  • 52.27
  • 49.51
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002082cardiac ventricle
  • HsapDv:000009025-44 year-old human stage (human)
2.46e4
  • 2.46e4
55.37
  • 55.37
AEIR
  • AEIR
UBERON:0003053ventricular zone
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:0000199fifth LMP month human stage (human)
2.47e4
  • 2.47e4
  • 2.50e4
55.18
  • 55.18
  • 54.60
AEIR
  • AEIR
  • AEIR
UBERON:0002081cardiac atrium
  • HsapDv:000009025-44 year-old human stage (human)
2.48e4
  • 2.48e4
54.95
  • 54.95
AEIR
  • AEIR
UBERON:0001873caudate nucleus
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.48e4
  • 2.48e4
  • 2.91e4
  • 2.97e4
  • 3.00e4
54.94
  • 54.94
  • 47.21
  • 46.10
  • 45.59
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000955brain
  • UBERON:0007220late embryonic stage
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000089young adult stage (human)
  • HsapDv:000009580 year-old and over human stage (human)
  • UBERON:0000104life cycle
2.49e4
  • 2.49e4
  • 2.92e4
  • 2.96e4
  • 3.01e4
  • 3.04e4
  • 3.07e4
  • 3.11e4
  • 3.16e4
54.82
  • 54.82
  • 46.96
  • 46.33
  • 45.34
  • 44.85
  • 44.29
  • 43.47
  • 42.60
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000474female reproductive system
  • UBERON:0000104life cycle
2.49e4
  • 2.49e4
54.71
  • 54.71
AEIR
  • AEIR
UBERON:0009834dorsolateral prefrontal cortex
  • HsapDv:000009580 year-old and over human stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000088human early adulthood stage (human)
2.51e4
  • 2.51e4
  • 2.77e4
  • 2.78e4
  • 3.00e4
  • 3.08e4
54.46
  • 54.46
  • 49.71
  • 49.49
  • 45.50
  • 44.09
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000473testis
  • HsapDv:000009580 year-old and over human stage (human)
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000198fourth LMP month human stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • UBERON:0000104life cycle
  • HsapDv:0000092human middle aged stage (human)
2.58e4
  • 2.58e4
  • 2.84e4
  • 2.93e4
  • 3.00e4
  • 3.05e4
  • 3.22e4
  • 3.25e4
53.22
  • 53.22
  • 48.35
  • 46.83
  • 45.52
  • 44.59
  • 41.46
  • 40.95
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0005343cortical plate
  • HsapDv:0000198fourth LMP month human stage (human)
2.58e4
  • 2.58e4
53.07
  • 53.07
AEIR
  • AEIR
UBERON:0000082adult mammalian kidney
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000091human late adulthood stage (human)
2.62e4
  • 2.62e4
  • 3.01e4
  • 3.20e4
52.40
  • 52.40
  • 45.26
  • 41.85
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002038substantia nigra
  • UBERON:0000104life cycle
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
2.67e4
  • 2.67e4
  • 2.72e4
  • 2.93e4
51.59
  • 51.59
  • 50.58
  • 46.73
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001898hypothalamus
  • UBERON:0000113post-juvenile adult stage
  • UBERON:0000104life cycle
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.76e4
  • 2.76e4
  • 2.77e4
  • 2.89e4
  • 2.93e4
49.85
  • 49.85
  • 49.72
  • 47.58
  • 46.85
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001264pancreas
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.76e4
  • 2.76e4
  • 2.92e4
  • 4.06e4
49.83
  • 49.83
  • 47.05
  • 26.31
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001954Ammon's horn
  • UBERON:0000104life cycle
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
2.80e4
  • 2.80e4
  • 2.81e4
  • 2.96e4
  • 3.10e4
49.17
  • 49.17
  • 48.90
  • 46.28
  • 43.77
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001161body of stomach
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.83e4
  • 2.83e4
  • 2.88e4
  • 2.95e4
  • 2.99e4
  • 3.02e4
48.61
  • 48.61
  • 47.72
  • 46.48
  • 45.68
  • 45.13
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000178blood
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:000009025-44 year-old human stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:000009465-79 year-old human stage (human)
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000091human late adulthood stage (human)
2.89e4
  • 2.89e4
  • 3.04e4
  • 3.04e4
  • 3.21e4
  • 3.26e4
  • 3.37e4
  • 3.38e4
  • 3.51e4
47.53
  • 47.53
  • 44.83
  • 44.71
  • 41.76
  • 40.76
  • 38.84
  • 38.65
  • 36.31
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001155colon
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
2.94e4
  • 2.94e4
  • 3.29e4
46.58
  • 46.58
  • 40.17
AEIR
  • AEIR
  • AEIR
UBERON:0001043esophagus
  • HsapDv:0000092human middle aged stage (human)
  • UBERON:0000113post-juvenile adult stage
  • HsapDv:0000087human adult stage (human)
3.04e4
  • 3.04e4
  • 3.30e4
  • 4.55e4
44.72
  • 44.72
  • 40.13
  • 17.43
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000014zone of skin
  • HsapDv:0000087human adult stage (human)
  • UBERON:0000104life cycle
  • UBERON:0000113post-juvenile adult stage
3.07e4
  • 3.07e4
  • 3.10e4
  • 3.76e4
44.22
  • 44.22
  • 43.65
  • 31.77
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0002810right frontal lobe
  • HsapDv:0000087human adult stage (human)
3.07e4
  • 3.07e4
44.21
  • 44.21
AEIR
  • AEIR
UBERON:0004533left testis
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000088human early adulthood stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:000009025-44 year-old human stage (human)
3.09e4
  • 3.09e4
  • 3.12e4
  • 3.14e4
  • 3.15e4
  • 3.28e4
43.95
  • 43.95
  • 43.35
  • 42.91
  • 42.77
  • 40.49
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
CL:0000576monocyte
  • UBERON:0000113post-juvenile adult stage
3.12e4
  • 3.12e4
43.28
  • 43.28
AEIR
  • AEIR
UBERON:0003454small intestine Peyer's patch
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
3.15e4
  • 3.15e4
  • 3.16e4
  • 3.17e4
42.85
  • 42.85
  • 42.59
  • 42.36
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0008952upper lobe of left lung
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
  • HsapDv:0000087human adult stage (human)
3.20e4
  • 3.20e4
  • 3.59e4
  • 3.59e4
41.87
  • 41.87
  • 34.81
  • 34.79
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001383muscle of leg
  • HsapDv:0000088human early adulthood stage (human)
3.66e4
  • 3.66e4
33.60
  • 33.60
AEIR
  • AEIR
UBERON:0002469esophagus mucosa
  • HsapDv:0000087human adult stage (human)
  • HsapDv:0000092human middle aged stage (human)
  • HsapDv:0000091human late adulthood stage (human)
3.70e4
  • 3.70e4
  • 3.83e4
  • 3.87e4
32.78
  • 32.78
  • 30.53
  • 29.71
AEIR
  • AEIR
  • AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
  • Affymetrix data: Bgee
  • RNA-Seq data: Bgee
Sources of raw data:

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
Homininae1 species1 geneCompare expression
Catarrhini2 species2 genesCompare expression
Euarchontoglires5 species5 genesCompare expression
Boreoeutheria10 species10 genesCompare expression
Theria11 species11 genesCompare expression
Mammalia12 species12 genesCompare expression
Tetrapoda13 species13 genesCompare expression
Euteleostomi14 species14 genesCompare expression

Orthology information comes from OMA : ENSG00000185974.

Paralogs (same species)

Taxon nameGene(s)Expression comparisonSee details
Eukaryota334 genesCompare expression

Paralogy information comes from OMA : ENSG00000185974.

Cross-references

EnsemblENSG00000185974 (GRK1)
HGNCHGNC:10013 (GRK1)
EMBLAC187648, AK289912, L77496, L77497, L77498, L77499, L77500, L77501, L77502, L77503, U63973
OncoMXGRK1 (GRK1)
Uniprot/SWISSPROTQ15835, RK_HUMAN

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