D. melanogaster Gene: bib - FBgn0000180 - Drosophila melanogaster (fruit fly)

General information

Ensembl IDFBgn0000180
Namebib
Descriptionbig brain [Source:FlyBase gene name;Acc:FBgn0000180]
OrganismDrosophila melanogaster (fruit fly)
Synonym(s)bib, bib_drome, big brain, cg4722, cg4722-pa, dmel\cg4722, ep(2)2278, l(2)neo66, l(2)neo91, m-bib, q9vl53

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0000922embryo
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005321extended germ band stage (Drosophila)
  • FBdv:00005312embryonic cycle 14 (Drosophila)
  • FBdv:00005311embryonic stage 5 (Drosophila)
  • FBdv:00004450late extended germ band stage (Drosophila)
  • FBdv:00014201early extended germ band stage (Drosophila)
  • FBdv:00005306embryonic stage 4 (Drosophila)
  • FBdv:00005290pre-blastoderm stage (Drosophila)
  • UBERON:0000068embryo stage
  • FBdv:00005309embryonic cycle 13 (Drosophila)
  • FBdv:00005331dorsal closure stage (Drosophila)
  • FBdv:00005304blastoderm stage (Drosophila)
  • FBdv:00005293embryonic stage 2 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
515
  • 515
  • 1.38e3
  • 1.40e3
  • 1.71e3
  • 1.79e3
  • 2.04e3
  • 4.59e3
  • 4.65e3
  • 4.85e3
  • 6.20e3
  • 6.23e3
  • 7.36e3
  • 8.15e3
  • 1.04e4
  • 1.16e4
  • 1.17e4
97.01925
  • 97.01925
  • 91.98191
  • 91.86694
  • 90.06534
  • 89.64860
  • 88.19747
  • 73.37883
  • 73.05519
  • 71.88004
  • 64.08065
  • 63.85691
  • 57.35332
  • 52.73655
  • 39.85964
  • 32.78322
  • 32.15399
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001778wing disc (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
2.51e3
  • 2.51e3
85.46747
  • 85.46747
AEIR
  • AEIR
UBERON:0003142prepupa
  • FBdv:00005342prepupal stage (Drosophila)
  • FBdv:00005343prepupal stage P1 (Drosophila)
3.01e3
  • 3.01e3
  • 6.56e3
82.52812
  • 82.52812
  • 61.96144
AEIR
  • AEIR
  • AEIR
UBERON:0000939imaginal disc
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
4.33e3
  • 4.33e3
  • 6.85e3
74.88816
  • 74.88816
  • 60.26623
AEIR
  • AEIR
  • AEIR
FBbt:00001684embryonic/larval hemocyte (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
4.41e3
  • 4.41e3
74.46214
  • 74.46214
AEIR
  • AEIR
UBERON:0007023adult organism
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00007078day 3 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
  • FBdv:00007092day 17 of adulthood (Drosophila)
4.55e3
  • 4.55e3
  • 1.13e4
  • 1.28e4
  • 1.31e4
73.64147
  • 73.64147
  • 34.24281
  • 25.77012
  • 23.95640
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0013765digestive system element
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00007095day 20 of adulthood (Drosophila)
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • FBdv:00007076day 1 of adulthood (Drosophila)
4.67e3
  • 4.67e3
  • 6.51e3
  • 8.49e3
  • 1.03e4
  • 1.22e4
72.94237
  • 72.94237
  • 62.24055
  • 50.80351
  • 40.53977
  • 29.10482
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001017central nervous system
  • FBdv:00005355pharate adult stage P8 (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
4.88e3
  • 4.88e3
  • 5.62e3
71.70657
  • 71.70657
  • 67.44469
AEIR
  • AEIR
  • AEIR
UBERON:0007010cleaving embryo
  • UBERON:0000107cleavage stage
5.52e3
  • 5.52e3
67.99536
  • 67.99536
AEIR
  • AEIR
UBERON:0003143pupa
  • FBdv:00005348prepupal stage P4(ii) (Drosophila)
  • FBdv:00005353pupal stage P6 (Drosophila)
  • UBERON:0000070pupal stage
  • FBdv:00005355pharate adult stage P8 (Drosophila)
  • FBdv:00005356pharate adult stage P9 (Drosophila)
  • FBdv:00005366pharate adult stage P15 (Drosophila)
6.19e3
  • 6.19e3
  • 8.35e3
  • 1.05e4
  • 1.10e4
  • 1.26e4
  • 1.37e4
64.10221
  • 64.10221
  • 51.57566
  • 39.34949
  • 36.51948
  • 26.76687
  • 20.54082
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001768eye disc (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
6.59e3
  • 6.59e3
61.77365
  • 61.77365
AEIR
  • AEIR
UBERON:0002548larva
  • FBdv:00007005third instar larval stage L2 (Drosophila)
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00007021third instar - cleared gut stage (Drosophila)
  • FBdv:00007020third instar - partially cleared gut stage (Drosophila)
  • UBERON:0004730instar larval stage
  • FBdv:00007019third instar - uncleared gut stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00007007late third instar larval stage (Drosophila)
  • UBERON:0000069larval stage
  • FBdv:00005338second instar larval stage (Drosophila)
6.93e3
  • 6.93e3
  • 7.51e3
  • 7.99e3
  • 9.81e3
  • 1.11e4
  • 1.12e4
  • 1.12e4
  • 1.12e4
  • 1.14e4
  • 1.29e4
59.85129
  • 59.85129
  • 56.48423
  • 53.67701
  • 43.14361
  • 35.71330
  • 35.14512
  • 34.97890
  • 34.80479
  • 34.10250
  • 24.98939
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
CL:0000025egg cell
  • FBdv:00005287unfertilized egg stage
7.22e3
  • 7.22e3
58.17237
  • 58.17237
AEIR
  • AEIR
UBERON:0003917arthropod fat body
  • FBdv:00005355pharate adult stage P8 (Drosophila)
  • UBERON:0000069larval stage
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • UBERON:0004730instar larval stage
7.77e3
  • 7.77e3
  • 9.78e3
  • 1.00e4
  • 1.24e4
  • 1.25e4
  • 1.30e4
54.98388
  • 54.98388
  • 43.29198
  • 41.81093
  • 28.17353
  • 27.40608
  • 24.89981
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001044saliva-secreting gland
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
8.17e3
  • 8.17e3
  • 8.29e3
  • 1.23e4
52.63074
  • 52.63074
  • 51.95304
  • 28.88920
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001045midgut
  • UBERON:0000069larval stage
8.30e3
  • 8.30e3
51.91327
  • 51.91327
AEIR
  • AEIR
CL:0000066epithelial cell
  • UBERON:0000068embryo stage
8.62e3
  • 8.62e3
50.00290
  • 50.00290
AEIR
  • AEIR
FBbt:00000186embryonic optic lobe primordium (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00290
  • 50.00290
  • 50.00290
  • 50.00000
  • 50.00000
  • 50.00000
  • 50.00000
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001069embryonic stomatogastric nervous system (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.63e3
50.00290
  • 50.00290
  • 50.00290
  • 50.00290
  • 50.00000
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00005466pericardial cell primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
50.00290
  • 50.00290
  • 50.00290
AEIR
  • AEIR
  • AEIR
FBbt:00005533ventral epidermis primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
50.00290
  • 50.00290
  • 50.00290
AEIR
  • AEIR
  • AEIR
FBbt:00005665embryonic central brain neuron (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
50.00290
  • 50.00290
  • 50.00290
  • 50.00290
  • 50.00290
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000924ectoderm
  • FBdv:00005313embryonic cycle 14A (Drosophila)
  • FBdv:00005314embryonic cycle 14B (Drosophila)
  • FBdv:00005315embryonic cycle 15 (Drosophila)
  • FBdv:00005316embryonic cycle 16 (Drosophila)
  • FBdv:00005319embryonic stage 7 (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005311embryonic stage 5 (Drosophila)
  • FBdv:00005318embryonic stage 6 (Drosophila)
  • FBdv:00005322embryonic stage 8 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00290
  • 50.00290
  • 50.00290
  • 50.00290
  • 50.00290
  • 50.00290
  • 50.00290
  • 50.00000
  • 50.00000
  • 50.00000
  • 50.00000
  • 50.00000
  • 50.00000
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00000128trunk mesoderm (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 50.00000
AEIR
  • AEIR
  • AEIR
FBbt:00005037tracheal primordium (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 49.99710
AEIR
  • AEIR
  • AEIR
FBbt:00005413anlage in statu nascendi (Drosophila)
  • FBdv:00005306embryonic stage 4 (Drosophila)
  • FBdv:00005311embryonic stage 5 (Drosophila)
  • FBdv:00005318embryonic stage 6 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 50.00000
  • 50.00000
AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00005528midline primordium (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 50.00000
  • 49.99710
  • 49.99710
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00005536stomatogastric nervous system primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 50.00000
AEIR
  • AEIR
  • AEIR
FBbt:00005542central brain primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 50.00000
AEIR
  • AEIR
  • AEIR
FBbt:00005667embryonic central brain pars intercerebralis (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 50.00000
  • 50.00000
  • 50.00000
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000926mesoderm
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00000
  • 50.00000
  • 50.00000
  • 49.99710
  • 49.99710
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00005511pars intercerebralis primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
49.99710
  • 49.99710
  • 49.99710
AEIR
  • AEIR
  • AEIR
UBERON:0000033head
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • FBdv:00007078day 3 of adulthood (Drosophila)
  • UBERON:0000104life cycle
  • FBdv:00007076day 1 of adulthood (Drosophila)
  • FBdv:00007095day 20 of adulthood (Drosophila)
  • FBdv:00007085day 10 of adulthood (Drosophila)
  • FBdv:00007083day 8 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
8.91e3
  • 8.91e3
  • 8.96e3
  • 9.16e3
  • 9.27e3
  • 9.42e3
  • 9.68e3
  • 1.06e4
  • 1.08e4
48.31986
  • 48.31986
  • 48.03954
  • 46.89054
  • 46.28548
  • 45.38399
  • 43.85685
  • 38.30380
  • 37.47113
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0003153head capsule
  • UBERON:0000066fully formed stage
9.49e3
  • 9.49e3
45.01032
  • 45.01032
AEIR
  • AEIR
UBERON:0000992female gonad
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
9.57e3
  • 9.57e3
  • 1.23e4
44.54058
  • 44.54058
  • 28.50458
AEIR
  • AEIR
  • AEIR
CL:0000023oocyte
  • UBERON:0000066fully formed stage
1.04e4
  • 1.04e4
39.70252
  • 39.70252
AEIR
  • AEIR
UBERON:0000955brain
  • UBERON:0000066fully formed stage
1.06e4
  • 1.06e4
38.68060
  • 38.68060
AEIR
  • AEIR
UBERON:0000473testis
  • UBERON:0000066fully formed stage
  • FBdv:00007079day 4 of adulthood (Drosophila)
1.10e4
  • 1.10e4
  • 1.31e4
36.04256
  • 36.04256
  • 24.16037
AEIR
  • AEIR
  • AEIR
UBERON:0006868seminal fluid secreting gland
  • UBERON:0000066fully formed stage
1.22e4
  • 1.22e4
29.45692
  • 29.45692
AEIR
  • AEIR
UBERON:0005399male reproductive gland
  • FBdv:00007079day 4 of adulthood (Drosophila)
1.38e4
  • 1.38e4
19.85048
  • 19.85048
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
Sources of raw data:

Cross-references

EMBLAE014134, AY051981, X53275
EnsemblFBgn0000180 (bib)
FlyBaseCG4722, FBgn0000180 (bib)
Uniprot/SPTREMBLM9PB86, M9PB86_DROME
Uniprot/SWISSPROTBIB_DROME, P23645

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