D. melanogaster Gene: tws - FBgn0004889 - Drosophila melanogaster (fruit fly)

General information

Ensembl IDFBgn0004889
Nametws
Descriptiontwins [Source:FlyBase gene name;Acc:FBgn0004889]
OrganismDrosophila melanogaster (fruit fly)
Synonym(s)1466/06, 2414, a4v2m9, a4v2n0, aar, abnormal anaphase resolution, b/pr55, cg6235, cg6235-pa, cg6235-pb, cg6235-pc, cg6235-pd, cg6235-pe, cg6235-pf, cg6235-pg, cg6235-ph, cg6235-ra, cg6235-rb, cg6235-rc, cg6235-rd, cg6235-re, cg6235-rf, cg6235-rg, cg6235-rh, dmel\cg6235, dpp2a, dpp2a-b55, dpp2a-balpha, dpr55, fbgn0004906, fbgn0010249, fbgn0010748, fbgn0010780, fbgn0011012, fbgn0011434, fbgn0028118, fbgn0037791, fbgn0060325, fbgn0060355, fbgn0060382, fbgn0060393, fbgn0060451, fbgn0060476, fbgn0060482, fbgn0060490, fbgn0060503, fbgn0060530, fbgn0060599, fbgn0060620, fbgn0060667, fbgn0060680, fbgn0060683, fbgn0060685, fbgn0060686, fbgn0060717, fbgn0060727, fbgn0060736, fbgn0060738, fbgn0060744, fbgn0060764, fbgn0060771, fbgn0060777, fbgn0060782, fbgn0060814, fbgn0060817, fbgn0060835, fbgn0060851, fbgn0060857, fbgn0060858, fbgn0060872, fbgn0060877, fbgn0060907, fbgn0060908, fbgn0060915, fbgn0060916, fbgn0060954, fbgn0060957, fbgn0060959, fbgn0060962, fbgn0060965, fbgn0060971, fbgn0060972, fbgn0060974, fbgn0060977, fbgn0060995, fbgn0060996, fbgn0061006, fbgn0061008, fbgn0061016, fbgn0061017, fbgn0061018, fbgn0061025, fbgn0061026, fbgn0061030, fbgn0061036, fbgn0061050, fbgn0061051, fbgn0061053, fbgn0061055, fbgn0061059, fbgn0061060, fbgn0061062, fbtr0002443, fbtr0002444, fbtr0007034, fbtr0007035, fbtr0007036, fbtr0007037, l(3)01436, l(3)02414, l(3)j11c8, l(3)s022205b, l(3)s022361, l(3)s022440, l(3)s023013, l(3)s023141a, l(3)s023206, l(3)s023309, l(3)s023938, l(3)s024455, l(3)s024834a, l(3)s024838, l(3)s025806, l(3)s025832, l(3)s025913, l(3)s026226, l(3)s026326, l(3)s027127, l(3)s027313, l(3)s028707, l(3)s029110, l(3)s029403, l(3)s029701a, l(3)s031006, l(3)s032303, l(3)s032708c, l(3)s033903, l(3)s035505b, l(3)s042629, l(3)s042630, l(3)s043008b, l(3)s043029, l(3)s045519, l(3)s046918, l(3)s048006, l(3)s048013, l(3)s048507, l(3)s049902, l(3)s052810, l(3)s053011, l(3)s060203, l(3)s060804, l(3)s061805, l(3)s061915, l(3)s063110, l(3)s066017, l(3)s066813, l(3)s067109b, l(3)s067915, l(3)s069206a, l(3)s075110, l(3)s075515b, l(3)s075902b, l(3)s076415, l(3)s080409, l(3)s088513, l(3)s091905, l(3)s101413b, l(3)s105605, l(3)s110008a, l(3)s110815, l(3)s111515, l(3)s119908, l(3)s132907, l(3)s134601a, l(3)s141309, l(3)s146606, l(3)s1801, phosphoprotein phosphatase 2a 55 kda, pp2a, pp2a regulatory subunit, pp2a regulatory subunit twins, pp2a-85f, pp2a-b55, pp2a[b], pr55, protein phosphatase 2a, protein phosphatase 2a at 85f, protein phosphatase type 2a, q9vh21, q9vh22, regulatory b subunit of type 2a protein phosphatase, tw, twins, tws, tws/aar, tws[+]r2.75, v158
Orthologs(s)79 orthologs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0000922embryo
  • FBdv:00005304blastoderm stage (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
  • FBdv:00005306embryonic stage 4 (Drosophila)
  • FBdv:00005321extended germ band stage (Drosophila)
  • FBdv:00004450late extended germ band stage (Drosophila)
  • UBERON:0000068embryo stage
  • FBdv:00005312embryonic cycle 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005290pre-blastoderm stage (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
  • FBdv:00005311embryonic stage 5 (Drosophila)
  • FBdv:00005293embryonic stage 2 (Drosophila)
  • FBdv:00005309embryonic cycle 13 (Drosophila)
  • FBdv:00005331dorsal closure stage (Drosophila)
  • FBdv:00014201early extended germ band stage (Drosophila)
308
  • 308
  • 3.27e3
  • 3.32e3
  • 3.54e3
  • 3.62e3
  • 3.66e3
  • 3.74e3
  • 4.41e3
  • 4.46e3
  • 4.59e3
  • 4.65e3
  • 4.67e3
  • 4.67e3
  • 4.72e3
  • 4.82e3
  • 5.29e3
98.22
  • 98.22
  • 81.04
  • 80.78
  • 79.47
  • 79.02
  • 78.80
  • 78.32
  • 74.42
  • 74.17
  • 73.37
  • 73.06
  • 72.94
  • 72.92
  • 72.66
  • 72.09
  • 69.31
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00003143adult hindgut (Drosophila)
  • UBERON:0000066fully formed stage
435
  • 435
97.48
  • 97.48
AEIR
  • AEIR
UBERON:0003199egg chamber
  • FBdv:00005286egg stage
504
  • 504
97.08
  • 97.08
AEIR
  • AEIR
UBERON:0000992female gonad
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
  • FBdv:00005266oogenesis stage S6
709
  • 709
  • 3.54e3
  • 8.49e3
95.90
  • 95.90
  • 79.50
  • 50.78
AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00004052thoracico-abdominal ganglion (Drosophila)
  • UBERON:0000066fully formed stage
958
  • 958
94.45
  • 94.45
AEIR
  • AEIR
FBbt:00001778wing disc (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
1.02e3
  • 1.02e3
94.09
  • 94.09
AEIR
  • AEIR
UBERON:0000939imaginal disc
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
1.08e3
  • 1.08e3
  • 1.27e3
93.73
  • 93.73
  • 92.64
AEIR
  • AEIR
  • AEIR
UBERON:0001054Malpighian tubule
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • UBERON:0000104life cycle
  • UBERON:0000066fully formed stage
  • FBdv:00005335embryonic stage 17 (Drosophila)
1.08e3
  • 1.08e3
  • 2.55e3
  • 2.65e3
  • 8.62e3
93.73
  • 93.73
  • 85.21
  • 84.64
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00003133crop (Drosophila)
  • UBERON:0000066fully formed stage
1.13e3
  • 1.13e3
93.46
  • 93.46
AEIR
  • AEIR
UBERON:0001017central nervous system
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00005355pharate adult stage P8 (Drosophila)
1.27e3
  • 1.27e3
  • 2.06e3
92.66
  • 92.66
  • 88.08
AEIR
  • AEIR
  • AEIR
UBERON:0002548larva
  • FBdv:00007005third instar larval stage L2 (Drosophila)
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00007021third instar - cleared gut stage (Drosophila)
  • FBdv:00007020third instar - partially cleared gut stage (Drosophila)
  • FBdv:00007019third instar - uncleared gut stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • UBERON:0004730instar larval stage
  • FBdv:00007007late third instar larval stage (Drosophila)
  • FBdv:00005340early third instar larval stage (Drosophila)
  • FBdv:00005337first instar larval stage (Drosophila)
  • FBdv:00005338second instar larval stage (Drosophila)
  • UBERON:0000069larval stage
1.27e3
  • 1.27e3
  • 1.87e3
  • 2.04e3
  • 2.48e3
  • 2.51e3
  • 2.60e3
  • 2.70e3
  • 2.75e3
  • 2.87e3
  • 3.13e3
  • 3.22e3
  • 4.24e3
92.64
  • 92.64
  • 89.19
  • 88.20
  • 85.63
  • 85.46
  • 84.95
  • 84.35
  • 84.06
  • 83.34
  • 81.89
  • 81.31
  • 75.45
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00005725adult Malpighian tubule (Drosophila)
  • UBERON:0000066fully formed stage
1.30e3
  • 1.30e3
92.46
  • 92.46
AEIR
  • AEIR
UBERON:0000033head
  • FBdv:00005364pharate adult stage P13 (Drosophila)
  • UBERON:0000104life cycle
  • FBdv:00007095day 20 of adulthood (Drosophila)
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • FBdv:00007076day 1 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
  • FBdv:00007078day 3 of adulthood (Drosophila)
  • FBdv:00007085day 10 of adulthood (Drosophila)
  • FBdv:00007083day 8 of adulthood (Drosophila)
1.30e3
  • 1.30e3
  • 1.59e3
  • 1.81e3
  • 2.07e3
  • 2.09e3
  • 2.14e3
  • 2.26e3
  • 2.58e3
  • 2.82e3
92.44
  • 92.44
  • 90.81
  • 89.53
  • 87.98
  • 87.90
  • 87.58
  • 86.93
  • 85.07
  • 83.68
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000955brain
  • UBERON:0000066fully formed stage
1.32e3
  • 1.32e3
92.34
  • 92.34
AEIR
  • AEIR
UBERON:0013765digestive system element
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00007095day 20 of adulthood (Drosophila)
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00007076day 1 of adulthood (Drosophila)
1.37e3
  • 1.37e3
  • 1.65e3
  • 2.03e3
  • 2.51e3
  • 2.58e3
92.06
  • 92.06
  • 90.46
  • 88.24
  • 85.48
  • 85.07
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0007023adult organism
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00007092day 17 of adulthood (Drosophila)
  • FBdv:00007105day 30 of adulthood (Drosophila)
  • FBdv:00007076day 1 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
  • FBdv:00007078day 3 of adulthood (Drosophila)
  • FBdv:00007080day 5 of adulthood (Drosophila)
1.45e3
  • 1.45e3
  • 1.72e3
  • 1.99e3
  • 2.53e3
  • 2.78e3
  • 2.92e3
  • 2.98e3
91.61
  • 91.61
  • 90.02
  • 88.49
  • 85.34
  • 83.89
  • 83.09
  • 82.72
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00004784capitellum (Drosophila)
  • UBERON:0000066fully formed stage
1.48e3
  • 1.48e3
91.44
  • 91.44
AEIR
  • AEIR
UBERON:0003142prepupa
  • FBdv:00005342prepupal stage (Drosophila)
  • FBdv:00005343prepupal stage P1 (Drosophila)
1.71e3
  • 1.71e3
  • 1.94e3
90.08
  • 90.08
  • 88.77
AEIR
  • AEIR
  • AEIR
FBbt:00004514second segment of antenna (Drosophila)
  • UBERON:0000066fully formed stage
1.73e3
  • 1.73e3
89.99
  • 89.99
AEIR
  • AEIR
UBERON:0000994spermathecum
  • UBERON:0000066fully formed stage
1.83e3
  • 1.83e3
89.39
  • 89.39
AEIR
  • AEIR
UBERON:0003143pupa
  • FBdv:00005348prepupal stage P4(ii) (Drosophila)
  • FBdv:00005353pupal stage P6 (Drosophila)
  • FBdv:00005366pharate adult stage P15 (Drosophila)
  • FBdv:00005355pharate adult stage P8 (Drosophila)
  • FBdv:00005356pharate adult stage P9 (Drosophila)
  • UBERON:0000070pupal stage
1.89e3
  • 1.89e3
  • 1.98e3
  • 2.04e3
  • 3.06e3
  • 3.24e3
  • 4.60e3
89.02
  • 89.02
  • 88.50
  • 88.17
  • 82.26
  • 81.23
  • 73.34
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0003153head capsule
  • UBERON:0000066fully formed stage
2.00e3
  • 2.00e3
88.42
  • 88.42
AEIR
  • AEIR
UBERON:0003917arthropod fat body
  • UBERON:0000066fully formed stage
  • UBERON:0004730instar larval stage
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • UBERON:0000069larval stage
  • FBdv:00005355pharate adult stage P8 (Drosophila)
2.18e3
  • 2.18e3
  • 2.31e3
  • 2.55e3
  • 2.62e3
  • 2.63e3
  • 3.26e3
  • 4.72e3
87.34
  • 87.34
  • 86.60
  • 85.21
  • 84.83
  • 84.73
  • 81.10
  • 72.66
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00004911oviduct (Drosophila)
  • UBERON:0000066fully formed stage
2.25e3
  • 2.25e3
86.97
  • 86.97
AEIR
  • AEIR
UBERON:0001044saliva-secreting gland
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
2.31e3
  • 2.31e3
  • 2.49e3
  • 3.25e3
86.59
  • 86.59
  • 85.55
  • 81.15
AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00003138adult midgut (Drosophila)
  • UBERON:0000066fully formed stage
2.48e3
  • 2.48e3
85.63
  • 85.63
AEIR
  • AEIR
UBERON:0000468multi-cellular organism
  • UBERON:0000092post-embryonic stage
  • FBdv:00005301embryonic stage 3 (Drosophila)
  • FBdv:00005306embryonic stage 4 (Drosophila)
2.60e3
  • 2.60e3
  • 8.63e3
  • 8.63e3
84.90
  • 84.90
  • 49.99
  • 49.99
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006868seminal fluid secreting gland
  • UBERON:0000066fully formed stage
2.68e3
  • 2.68e3
84.49
  • 84.49
AEIR
  • AEIR
FBbt:00001768eye disc (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
2.88e3
  • 2.88e3
83.31
  • 83.31
AEIR
  • AEIR
UBERON:0001045midgut
  • UBERON:0000066fully formed stage
  • UBERON:0000069larval stage
  • FBdv:00005339third instar larval stage (Drosophila)
3.17e3
  • 3.17e3
  • 3.53e3
  • 5.52e3
81.66
  • 81.66
  • 79.56
  • 68.03
AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001684embryonic/larval hemocyte (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
3.24e3
  • 3.24e3
81.23
  • 81.23
AEIR
  • AEIR
FBbt:00004520mouthpart (Drosophila)
  • UBERON:0000066fully formed stage
3.45e3
  • 3.45e3
80.01
  • 80.01
AEIR
  • AEIR
UBERON:0007010cleaving embryo
  • UBERON:0000107cleavage stage
3.49e3
  • 3.49e3
79.75
  • 79.75
AEIR
  • AEIR
UBERON:0005399male reproductive gland
  • FBdv:00007079day 4 of adulthood (Drosophila)
4.30e3
  • 4.30e3
75.08
  • 75.08
AEIR
  • AEIR
UBERON:0000473testis
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
  • FBdv:00006011pharate adult stage (Drosophila)
4.34e3
  • 4.34e3
  • 5.50e3
  • 8.62e3
74.85
  • 74.85
  • 68.14
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
CL:0000023oocyte
  • UBERON:0000066fully formed stage
4.58e3
  • 4.58e3
73.48
  • 73.48
AEIR
  • AEIR
FBbt:00003023adult abdomen (Drosophila)
  • UBERON:0000066fully formed stage
4.63e3
  • 4.63e3
73.19
  • 73.19
AEIR
  • AEIR
CL:0000025egg cell
  • FBdv:00005287unfertilized egg stage
4.83e3
  • 4.83e3
72.00
  • 72.00
AEIR
  • AEIR
CL:0000655secondary oocyte
  • FBdv:00005283oogenesis stage S14
4.96e3
  • 4.96e3
71.25
  • 71.25
AEIR
  • AEIR
CL:0000031neuroblast
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001891embryonic/larval hindgut (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
8.62e3
  • 8.62e3
50.00
  • 50.00
AEIR
  • AEIR
FBbt:00005785anal pad (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
8.62e3
  • 8.62e3
50.00
  • 50.00
AEIR
  • AEIR
UBERON:0000991gonad
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.62e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006795arthropod optic lobe
  • UBERON:0004730instar larval stage
8.62e3
  • 8.62e3
50.00
  • 50.00
AEIR
  • AEIR
CL:0000026invertebrate nurse cell
  • UBERON:0000066fully formed stage
8.63e3
  • 8.63e3
50.00
  • 50.00
AEIR
  • AEIR
FBbt:00001056presumptive embryonic/larval central nervous system (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
8.63e3
  • 8.63e3
50.00
  • 50.00
AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
Sources of raw data:

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
melanogaster subgroup2 species2 genesCompare expression
melanogaster group3 species3 genesCompare expression
Drosophila5 species5 genesCompare expression
Ecdysozoa6 species6 genesCompare expression
Bilateria26 species79 genesCompare expression

Orthology information comes from OMA : FBgn0004889.

Cross-references

EnsemblFBgn0004889 (tws)
EMBLAE014297, AY061152, BT099776, D13004, L07581, L07583, L07585, L07586, L12544
FlyBaseCG6235, FBgn0004889 (tws)
Uniprot/SPTREMBLC8VV30, C8VV30_DROME
Uniprot/SWISSPROT2ABA_DROME, P36872

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