We are happy to announce that we have released the new Bgee 15 version as a beta test. Please check it out at https://bgee.org/bgee15_0.

D. melanogaster Gene: Mkk4 - FBgn0024326 - Drosophila melanogaster (fruit fly)

General information

Ensembl IDFBgn0024326
NameMkk4
DescriptionMAP kinase kinase 4 [Source:FlyBase gene name;Acc:FBgn0024326]
OrganismDrosophila melanogaster (fruit fly)
Synonym(s)142758_at, cg9738, cg9738-pa, ct27508, d-mkk4, dmel\cg9738, dmkk4, drosophila map kinase kinase 4, fbgn0024950, fbgn0040310, hep, jnk kinase 2, jnkk2, map kinase kinase 4, mapkk4, mkk4, mpk4, o61445, sek1/mkk4
Orthologs(s)28 orthologs
Paralog(s)4 paralogs

Expression

Anat. entity IDAnatomical entityDevelopmental stage(s)Rank scoreExpression scoreSources
UBERON:0000955brain
  • UBERON:0000066fully formed stage
1.12e3
  • 1.12e3
93.53
  • 93.53
AEIR
  • AEIR
UBERON:0000033head
  • UBERON:0000104life cycle
  • FBdv:00005364pharate adult stage P13 (Drosophila)
  • FBdv:00007083day 8 of adulthood (Drosophila)
  • FBdv:00007085day 10 of adulthood (Drosophila)
  • FBdv:00007078day 3 of adulthood (Drosophila)
  • FBdv:00007095day 20 of adulthood (Drosophila)
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • FBdv:00007076day 1 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
1.53e3
  • 1.53e3
  • 2.90e3
  • 2.96e3
  • 3.08e3
  • 3.59e3
  • 3.71e3
  • 3.73e3
  • 4.00e3
  • 4.28e3
91.12
  • 91.12
  • 83.20
  • 82.83
  • 82.14
  • 79.19
  • 78.51
  • 78.39
  • 76.79
  • 75.22
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0000922embryo
  • FBdv:00005304blastoderm stage (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005321extended germ band stage (Drosophila)
  • FBdv:00005331dorsal closure stage (Drosophila)
  • FBdv:00004450late extended germ band stage (Drosophila)
  • UBERON:0000068embryo stage
  • FBdv:00005334embryonic stage 16 (Drosophila)
  • FBdv:00005335embryonic stage 17 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005312embryonic cycle 14 (Drosophila)
  • FBdv:00005306embryonic stage 4 (Drosophila)
  • FBdv:00005311embryonic stage 5 (Drosophila)
  • FBdv:00005290pre-blastoderm stage (Drosophila)
  • FBdv:00014201early extended germ band stage (Drosophila)
  • FBdv:00005309embryonic cycle 13 (Drosophila)
  • FBdv:00005293embryonic stage 2 (Drosophila)
1.62e3
  • 1.62e3
  • 2.20e3
  • 2.40e3
  • 3.08e3
  • 3.11e3
  • 3.16e3
  • 3.82e3
  • 4.41e3
  • 4.51e3
  • 4.70e3
  • 4.96e3
  • 5.04e3
  • 5.19e3
  • 5.30e3
  • 5.98e3
  • 6.76e3
90.63
  • 90.63
  • 87.27
  • 86.09
  • 82.17
  • 81.99
  • 81.66
  • 77.85
  • 74.45
  • 73.83
  • 72.75
  • 71.25
  • 70.79
  • 69.92
  • 69.28
  • 65.34
  • 60.82
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001684embryonic/larval hemocyte (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
1.63e3
  • 1.63e3
90.54
  • 90.54
AEIR
  • AEIR
UBERON:0003153head capsule
  • UBERON:0000066fully formed stage
1.79e3
  • 1.79e3
89.64
  • 89.64
AEIR
  • AEIR
UBERON:0001054Malpighian tubule
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • UBERON:0000066fully formed stage
  • UBERON:0000104life cycle
1.94e3
  • 1.94e3
  • 2.62e3
  • 2.99e3
88.76
  • 88.76
  • 84.84
  • 82.67
AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001778wing disc (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
2.12e3
  • 2.12e3
87.73
  • 87.73
AEIR
  • AEIR
UBERON:0003917arthropod fat body
  • UBERON:0004730instar larval stage
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • UBERON:0000066fully formed stage
  • UBERON:0000069larval stage
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00005355pharate adult stage P8 (Drosophila)
2.28e3
  • 2.28e3
  • 2.70e3
  • 2.73e3
  • 3.57e3
  • 3.62e3
  • 4.34e3
  • 5.11e3
86.81
  • 86.81
  • 84.34
  • 84.16
  • 79.33
  • 79.01
  • 74.86
  • 70.40
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001045midgut
  • FBdv:00005339third instar larval stage (Drosophila)
  • UBERON:0000066fully formed stage
  • UBERON:0000069larval stage
2.38e3
  • 2.38e3
  • 2.67e3
  • 2.68e3
86.20
  • 86.20
  • 84.53
  • 84.47
AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00003138adult midgut (Drosophila)
  • UBERON:0000066fully formed stage
2.41e3
  • 2.41e3
86.02
  • 86.02
AEIR
  • AEIR
UBERON:0013765digestive system element
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00007095day 20 of adulthood (Drosophila)
  • FBdv:00007076day 1 of adulthood (Drosophila)
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • FBdv:00005341wandering third instar larval stage (Drosophila)
2.57e3
  • 2.57e3
  • 2.97e3
  • 3.09e3
  • 3.14e3
  • 3.74e3
85.12
  • 85.12
  • 82.77
  • 82.10
  • 81.82
  • 78.30
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00003143adult hindgut (Drosophila)
  • UBERON:0000066fully formed stage
2.63e3
  • 2.63e3
84.79
  • 84.79
AEIR
  • AEIR
UBERON:0000992female gonad
  • FBdv:00007079day 4 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
  • FBdv:00005266oogenesis stage S6
2.72e3
  • 2.72e3
  • 6.12e3
  • 8.65e3
84.26
  • 84.26
  • 64.52
  • 49.85
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0001017central nervous system
  • FBdv:00005355pharate adult stage P8 (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
2.77e3
  • 2.77e3
  • 2.86e3
83.94
  • 83.94
  • 83.44
AEIR
  • AEIR
  • AEIR
UBERON:0003142prepupa
  • FBdv:00005342prepupal stage (Drosophila)
  • FBdv:00005343prepupal stage P1 (Drosophila)
2.83e3
  • 2.83e3
  • 3.09e3
83.60
  • 83.60
  • 82.06
AEIR
  • AEIR
  • AEIR
UBERON:0000994spermathecum
  • UBERON:0000066fully formed stage
2.84e3
  • 2.84e3
83.54
  • 83.54
AEIR
  • AEIR
UBERON:0001044saliva-secreting gland
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00005343prepupal stage P1 (Drosophila)
2.87e3
  • 2.87e3
  • 3.09e3
  • 3.26e3
83.38
  • 83.38
  • 82.12
  • 81.08
AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0007023adult organism
  • FBdv:00005343prepupal stage P1 (Drosophila)
  • FBdv:00007078day 3 of adulthood (Drosophila)
  • FBdv:00007080day 5 of adulthood (Drosophila)
  • FBdv:00007105day 30 of adulthood (Drosophila)
  • FBdv:00007092day 17 of adulthood (Drosophila)
  • FBdv:00007076day 1 of adulthood (Drosophila)
  • UBERON:0000066fully formed stage
2.94e3
  • 2.94e3
  • 3.94e3
  • 4.14e3
  • 4.17e3
  • 4.40e3
  • 4.64e3
  • 4.84e3
82.98
  • 82.98
  • 77.16
  • 76.03
  • 75.84
  • 74.49
  • 73.13
  • 71.94
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001768eye disc (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
2.95e3
  • 2.95e3
82.91
  • 82.91
AEIR
  • AEIR
FBbt:00003133crop (Drosophila)
  • UBERON:0000066fully formed stage
2.95e3
  • 2.95e3
82.90
  • 82.90
AEIR
  • AEIR
UBERON:0000972antenna
  • UBERON:0000066fully formed stage
3.08e3
  • 3.08e3
82.14
  • 82.14
AEIR
  • AEIR
UBERON:0002548larva
  • FBdv:00005341wandering third instar larval stage (Drosophila)
  • FBdv:00007021third instar - cleared gut stage (Drosophila)
  • FBdv:00007020third instar - partially cleared gut stage (Drosophila)
  • FBdv:00007019third instar - uncleared gut stage (Drosophila)
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00005338second instar larval stage (Drosophila)
  • FBdv:00005337first instar larval stage (Drosophila)
  • UBERON:0000069larval stage
  • FBdv:00007005third instar larval stage L2 (Drosophila)
  • UBERON:0004730instar larval stage
  • FBdv:00005340early third instar larval stage (Drosophila)
  • FBdv:00007007late third instar larval stage (Drosophila)
3.14e3
  • 3.14e3
  • 3.22e3
  • 3.47e3
  • 3.53e3
  • 3.58e3
  • 3.61e3
  • 3.67e3
  • 3.86e3
  • 4.25e3
  • 6.04e3
  • 6.31e3
  • 6.42e3
81.82
  • 81.82
  • 81.31
  • 79.86
  • 79.53
  • 79.27
  • 79.08
  • 78.75
  • 77.61
  • 75.35
  • 64.99
  • 63.42
  • 62.76
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
UBERON:0006868seminal fluid secreting gland
  • UBERON:0000066fully formed stage
3.15e3
  • 3.15e3
81.76
  • 81.76
AEIR
  • AEIR
FBbt:00004514second segment of antenna (Drosophila)
  • UBERON:0000066fully formed stage
3.56e3
  • 3.56e3
79.34
  • 79.34
AEIR
  • AEIR
UBERON:0003143pupa
  • FBdv:00005353pupal stage P6 (Drosophila)
  • FBdv:00005348prepupal stage P4(ii) (Drosophila)
  • FBdv:00005355pharate adult stage P8 (Drosophila)
  • FBdv:00005356pharate adult stage P9 (Drosophila)
  • FBdv:00005366pharate adult stage P15 (Drosophila)
  • UBERON:0000070pupal stage
3.60e3
  • 3.60e3
  • 3.85e3
  • 4.17e3
  • 4.82e3
  • 5.78e3
  • 6.04e3
79.15
  • 79.15
  • 77.66
  • 75.80
  • 72.05
  • 66.52
  • 65.02
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00004052thoracico-abdominal ganglion (Drosophila)
  • UBERON:0000066fully formed stage
3.64e3
  • 3.64e3
78.89
  • 78.89
AEIR
  • AEIR
FBbt:00004784capitellum (Drosophila)
  • UBERON:0000066fully formed stage
3.92e3
  • 3.92e3
77.28
  • 77.28
AEIR
  • AEIR
UBERON:0000468multi-cellular organism
  • UBERON:0000068embryo stage
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
  • UBERON:0000092post-embryonic stage
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005301embryonic stage 3 (Drosophila)
  • FBdv:00005319embryonic stage 7 (Drosophila)
  • FBdv:00005322embryonic stage 8 (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
  • FBdv:00005291embryonic stage 1 (Drosophila)
  • FBdv:00005293embryonic stage 2 (Drosophila)
  • FBdv:00005318embryonic stage 6 (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005306embryonic stage 4 (Drosophila)
  • FBdv:00005311embryonic stage 5 (Drosophila)
3.98e3
  • 3.98e3
  • 6.47e3
  • 6.47e3
  • 6.47e3
  • 6.63e3
  • 6.90e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
76.91
  • 76.91
  • 62.50
  • 62.50
  • 62.50
  • 61.54
  • 59.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.98
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00004520mouthpart (Drosophila)
  • UBERON:0000066fully formed stage
4.16e3
  • 4.16e3
75.90
  • 75.90
AEIR
  • AEIR
UBERON:0000939imaginal disc
  • FBdv:00005339third instar larval stage (Drosophila)
  • FBdv:00005341wandering third instar larval stage (Drosophila)
4.90e3
  • 4.90e3
  • 6.55e3
71.58
  • 71.58
  • 62.05
AEIR
  • AEIR
  • AEIR
UBERON:0003199egg chamber
  • FBdv:00005286egg stage
4.94e3
  • 4.94e3
71.35
  • 71.35
AEIR
  • AEIR
UBERON:0005399male reproductive gland
  • FBdv:00007079day 4 of adulthood (Drosophila)
5.38e3
  • 5.38e3
68.80
  • 68.80
AEIR
  • AEIR
FBbt:00004911oviduct (Drosophila)
  • UBERON:0000066fully formed stage
5.86e3
  • 5.86e3
66.04
  • 66.04
AEIR
  • AEIR
FBbt:00005725adult Malpighian tubule (Drosophila)
  • UBERON:0000066fully formed stage
6.04e3
  • 6.04e3
65.00
  • 65.00
AEIR
  • AEIR
UBERON:0007010cleaving embryo
  • UBERON:0000107cleavage stage
6.37e3
  • 6.37e3
63.08
  • 63.08
AEIR
  • AEIR
FBbt:00003023adult abdomen (Drosophila)
  • UBERON:0000066fully formed stage
6.38e3
  • 6.38e3
63.03
  • 63.03
AEIR
  • AEIR
CL:0000025egg cell
  • FBdv:00005287unfertilized egg stage
6.46e3
  • 6.46e3
62.55
  • 62.55
AEIR
  • AEIR
CL:0000655secondary oocyte
  • FBdv:00005283oogenesis stage S14
6.73e3
  • 6.73e3
60.99
  • 60.99
AEIR
  • AEIR
CL:0000023oocyte
  • UBERON:0000066fully formed stage
6.95e3
  • 6.95e3
59.71
  • 59.71
AEIR
  • AEIR
UBERON:0000473testis
  • UBERON:0000066fully formed stage
  • FBdv:00007079day 4 of adulthood (Drosophila)
8.20e3
  • 8.20e3
  • 8.37e3
52.45
  • 52.45
  • 51.45
AEIR
  • AEIR
  • AEIR
FBbt:00000210anterior endoderm anlage (Drosophila)
  • FBdv:00005319embryonic stage 7 (Drosophila)
  • FBdv:00005322embryonic stage 8 (Drosophila)
8.62e3
  • 8.62e3
  • 8.62e3
50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
FBbt:00000127head mesoderm (Drosophila)
  • FBdv:00005319embryonic stage 7 (Drosophila)
  • FBdv:00005322embryonic stage 8 (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00000128trunk mesoderm (Drosophila)
  • FBdv:00005319embryonic stage 7 (Drosophila)
  • FBdv:00005322embryonic stage 8 (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00005542central brain primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
FBbt:00005559anterior endoderm (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
FBbt:00005560posterior endoderm (Drosophila)
  • FBdv:00005319embryonic stage 7 (Drosophila)
  • FBdv:00005322embryonic stage 8 (Drosophila)
  • FBdv:00005323embryonic stage 9 (Drosophila)
  • FBdv:00005324embryonic stage 10 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00001882embryonic/larval midgut (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00005554ventral nerve cord primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 50.00
AEIR
  • AEIR
  • AEIR
UBERON:0000934ventral nerve cord
  • UBERON:0000068embryo stage
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
50.00
  • 50.00
  • 49.99
  • 49.99
  • 49.99
  • 49.99
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:00000444anterior midgut primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
49.99
  • 49.99
  • 49.99
AEIR
  • AEIR
  • AEIR
FBbt:00001060embryonic brain (Drosophila)
  • FBdv:00005328embryonic stage 13 (Drosophila)
  • FBdv:00005330embryonic stage 14 (Drosophila)
  • FBdv:00005332embryonic stage 15 (Drosophila)
  • FBdv:00005334embryonic stage 16 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
  • 8.63e3
49.99
  • 49.99
  • 49.99
  • 49.99
  • 49.99
AEIR
  • AEIR
  • AEIR
  • AEIR
  • AEIR
FBbt:10005329posterior midgut primordium (Drosophila)
  • FBdv:00005325embryonic stage 11 (Drosophila)
  • FBdv:00005327embryonic stage 12 (Drosophila)
8.63e3
  • 8.63e3
  • 8.63e3
49.99
  • 49.99
  • 49.99
AEIR
  • AEIR
  • AEIR
Sources
AAffymetrix
EEST
IIn Situ
RRNA-Seq
data
no data
Rank scores
3.25e4lightgrey: low confidence scores

important score variation

Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition. Max rank score in all species: 4.10e4. Min rank score varies across species.

Expression scores of expression calls use the minimum and maximum Rank of the species to normalize the expression to a value between 0 and 100. Low score means that the gene is lowly expressed in the condition.

Sources of annotations to anatomy and development:
Sources of raw data:

Orthologs

Taxon nameSpecies with orthologsGene(s)Expression comparisonSee details
melanogaster subgroup2 species2 genesCompare expression
melanogaster group3 species3 genesCompare expression
Drosophila5 species5 genesCompare expression
Ecdysozoa6 species7 genesCompare expression
Bilateria25 species28 genesCompare expression

Orthology information comes from OMA : FBgn0024326.

Paralogs (same species)

Taxon nameGene(s)Expression comparisonSee details
Metazoa1 geneCompare expression
Opisthokonta4 genesCompare expression

Paralogy information comes from OMA : FBgn0024326.

Cross-references

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