Bgee: Gene Expression Evolution

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Gene: TNF - ENSG00000204490 - Homo sapiens (human)

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Data parameters
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Gene namesTNF


  • DIF
  • TNF-alpha
  • TNFA
  • TNFSF2
Descriptiontumor necrosis factor [Source:HGNC Symbol;Acc:11892]
OrganismHomo sapiens (human) - Taxonomic identifier: 9606 [NCBI]
Gene typeprotein_coding
Expression dataNo expression data for this gene.

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Gene family identifierDescriptionPrediction methodGene count

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Hide | TopGene ontology

DomainGO terms
biological process
  • GO:0045416: positive regulation of interleukin-8 biosynthetic process [GO]
  • GO:0002925: positive regulation of humoral immune response mediated by circulating immunoglobulin [GO]
  • GO:0060557: positive regulation of vitamin D biosynthetic process [GO]
  • GO:0019722: calcium-mediated signaling [GO]
  • GO:0050901: leukocyte tethering or rolling [GO]
  • GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors [GO]
  • GO:0043068: positive regulation of programmed cell death [GO]
  • GO:0000185: activation of MAPKKK activity [GO]
  • GO:0045840: positive regulation of mitosis [GO]
  • GO:0070374: positive regulation of ERK1 and ERK2 cascade [GO]
  • GO:0032715: negative regulation of interleukin-6 production [GO]
  • GO:0051222: positive regulation of protein transport [GO]
  • GO:0043525: positive regulation of neuron apoptotic process [GO]
  • GO:0001932: regulation of protein phosphorylation [GO]
  • GO:0046330: positive regulation of JNK cascade [GO]
  • GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process [GO]
  • GO:0097191: extrinsic apoptotic signaling pathway [GO]
  • GO:0033209: tumor necrosis factor-mediated signaling pathway [GO]
  • GO:0045123: cellular extravasation [GO]
  • GO:0002876: positive regulation of chronic inflammatory response to antigenic stimulus [GO]
  • GO:0060555: induction of necroptosis by extracellular signals [GO]
  • GO:0050830: defense response to Gram-positive bacterium [GO]
  • GO:0008624: apoptotic signaling pathway [GO]
  • GO:0043066: negative regulation of apoptotic process [GO]
  • GO:0000165: MAPK cascade [GO]
  • GO:0045672: positive regulation of osteoclast differentiation [GO]
  • GO:0070265: necrotic cell death [GO]
  • GO:0031663: lipopolysaccharide-mediated signaling pathway [GO]
  • GO:0051092: positive regulation of NF-kappaB transcription factor activity [GO]
  • GO:0043491: protein kinase B signaling cascade [GO]
  • GO:0046325: negative regulation of glucose import [GO]
  • GO:0006917: induction of apoptosis [GO]
  • GO:0071803: positive regulation of podosome assembly [GO]
  • GO:0033138: positive regulation of peptidyl-serine phosphorylation [GO]
  • GO:0002740: negative regulation of cytokine secretion involved in immune response [GO]
  • GO:0014823: response to activity [GO]
  • GO:0050806: positive regulation of synaptic transmission [GO]
  • GO:0008285: negative regulation of cell proliferation [GO]
  • GO:0043065: positive regulation of apoptotic process [GO]
  • GO:0000122: negative regulation of transcription from RNA polymerase II promoter [GO]
  • GO:0045670: regulation of osteoclast differentiation [GO]
  • GO:0061048: negative regulation of branching involved in lung morphogenesis [GO]
  • GO:0031622: positive regulation of fever generation [GO]
  • GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity [GO]
  • GO:0009887: organ morphogenesis [GO]
  • GO:0043406: positive regulation of MAP kinase activity [GO]
  • GO:0001819: positive regulation of cytokine production [GO]
  • GO:0045994: positive regulation of translational initiation by iron [GO]
  • GO:0006916: negative regulation of apoptotic process [GO]
  • GO:0071677: positive regulation of mononuclear cell migration [GO]
  • GO:0032800: receptor biosynthetic process [GO]
  • GO:0045080: positive regulation of chemokine biosynthetic process [GO]
  • GO:0002439: chronic inflammatory response to antigenic stimulus [GO]
  • GO:0051897: positive regulation of protein kinase B signaling cascade [GO]
  • GO:0010940: positive regulation of necrotic cell death [GO]
  • GO:0050796: regulation of insulin secretion [GO]
  • GO:0007254: JNK cascade [GO]
  • GO:0000060: protein import into nucleus, translocation [GO]
  • GO:0045668: negative regulation of osteoblast differentiation [GO]
  • GO:0060693: regulation of branching involved in salivary gland morphogenesis [GO]
  • GO:0031334: positive regulation of protein complex assembly [GO]
  • GO:0051044: positive regulation of membrane protein ectodomain proteolysis [GO]
  • GO:0009651: response to salt stress [GO]
  • GO:0043243: positive regulation of protein complex disassembly [GO]
  • GO:0001775: cell activation [GO]
  • GO:0045944: positive regulation of transcription from RNA polymerase II promoter [GO]
  • GO:0006915: apoptotic process [GO]
  • GO:0071407: cellular response to organic cyclic compound [GO]
  • GO:0032755: positive regulation of interleukin-6 production [GO]
  • GO:0002037: negative regulation of L-glutamate transport [GO]
  • GO:0051798: positive regulation of hair follicle development [GO]
  • GO:0010888: negative regulation of lipid storage [GO]
  • GO:0045071: negative regulation of viral genome replication [GO]
  • GO:0050715: positive regulation of cytokine secretion [GO]
  • GO:0006959: humoral immune response [GO]
  • GO:0042493: response to drug [GO]
  • GO:0045599: negative regulation of fat cell differentiation [GO]
  • GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis [GO]
  • GO:0030730: sequestering of triglyceride [GO]
  • GO:0051023: regulation of immunoglobulin secretion [GO]
  • GO:0009615: response to virus [GO]
  • GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade [GO]
  • GO:0001666: response to hypoxia [GO]
  • GO:0045893: positive regulation of transcription, DNA-dependent [GO]
  • GO:0006006: glucose metabolic process [GO]
  • GO:0071316: cellular response to nicotine [GO]
  • GO:0032729: positive regulation of interferon-gamma production [GO]
  • GO:0051533: positive regulation of NFAT protein import into nucleus [GO]
  • GO:0010693: negative regulation of alkaline phosphatase activity [GO]
  • GO:0048661: positive regulation of smooth muscle cell proliferation [GO]
  • GO:0006954: inflammatory response [GO]
  • GO:2000343: positive regulation of chemokine (C-X-C motif) ligand 2 production [GO]
  • GO:0042346: positive regulation of NF-kappaB import into nucleus [GO]
  • GO:0045429: positive regulation of nitric oxide biosynthetic process [GO]
  • GO:0003009: skeletal muscle contraction [GO]
  • GO:0060559: positive regulation of calcidiol 1-monooxygenase activity [GO]
  • GO:0030198: extracellular matrix organization [GO]
  • GO:0050995: negative regulation of lipid catabolic process [GO]
  • GO:0009612: response to mechanical stimulus [GO]
  • GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade [GO]
  • GO:0000187: activation of MAPK activity [GO]
  • GO:0045892: negative regulation of transcription, DNA-dependent [GO]
  • GO:0071230: cellular response to amino acid stimulus [GO]
  • GO:0032722: positive regulation of chemokine production [GO]
  • GO:0001934: positive regulation of protein phosphorylation [GO]
  • GO:0051384: response to glucocorticoid stimulus [GO]
  • GO:0010629: negative regulation of gene expression [GO]
  • GO:0044130: negative regulation of growth of symbiont in host [GO]
  • GO:0048566: embryonic digestive tract development [GO]
  • GO:0006927: transformed cell apoptotic process [GO]
  • GO:2000010: positive regulation of protein localization to cell surface [GO]
  • GO:0034116: positive regulation of heterotypic cell-cell adhesion [GO]
cellular component
  • GO:0005886: plasma membrane [GO]
  • GO:0009986: cell surface [GO]
  • GO:0016021: integral to membrane [GO]
  • GO:0005615: extracellular space [GO]
  • GO:0009897: external side of plasma membrane [GO]
  • GO:0001891: phagocytic cup [GO]
  • GO:0045121: membrane raft [GO]
  • GO:0055037: recycling endosome [GO]
  • GO:0005887: integral to plasma membrane [GO]
molecular function
  • GO:0005515: protein binding [GO]
  • GO:0042802: identical protein binding [GO]
  • GO:0005164: tumor necrosis factor receptor binding [GO]
  • GO:0005125: cytokine activity [GO]
  • GO:0002020: protease binding [GO]
  • GO:0044212: transcription regulatory region DNA binding [GO]

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