Search Genes

Gene : PSEN1 - ENSG00000080815 - Homo sapiens (human)

General information

Expressed in middle frontal gyrus and 202 other cell types or tissues.

Gene identifier

ENSG00000080815

Name

PSEN1

Description

presenilin 1 [Source:HGNC Symbol;Acc:HGNC:9508]

Organism

Homo sapiens (human)

Synonym(s)

ad3,fad,s182,ps1

Orthologs

35 orthologs

Paralogs

2 paralogs

Source data

Retrieve all processed expression values for that gene

Expression graph

80%

Expression table

80%

Reported absence of expression

80%

Orthologs

Filter:

Taxon Name	Species with orthologs	Gene(s)	Expression comparison
Homininae	3 species Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee)	3 genes ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1	Compare expression
Catarrhini	9 species Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	9 genes ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSCSAG00000012773 PSEN1	Compare expression
Simiiformes	10 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	10 genes ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSCSAG00000012773 PSEN1	Compare expression
Primates	11 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey)	11 genes ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1	Compare expression
Euarchontoglires	15 species Mus musculus (mouse) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat)	15 genes ENSMUSG00000019969 Psen1 ENSOCUG00000014545 PSEN1 ENSCPOG00000035027 PSEN1 ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1 ENSRNOG00000009110 Psen1	Compare expression
Boreoeutheria	23 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat)	23 genes ENSMUSG00000019969 Psen1 ENSCAFG00000016815 PSEN1 ENSFCAG00000028093 PSEN1 ENSECAG00000004387 PSEN1 ENSSSCG00000002340 PSEN1 ENSBTAG00000011757 PSEN1 ENSCHIG00000025284 PSEN1 ENSOARG00000000358 PSEN1 ENSOCUG00000014545 PSEN1 ENSCPOG00000035027 PSEN1 ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1 108395378 PSEN1 ENSRNOG00000009110 Psen1	Compare expression
Theria	24 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Monodelphis domestica (opossum)	24 genes ENSMUSG00000019969 Psen1 ENSCAFG00000016815 PSEN1 ENSFCAG00000028093 PSEN1 ENSECAG00000004387 PSEN1 ENSSSCG00000002340 PSEN1 ENSBTAG00000011757 PSEN1 ENSCHIG00000025284 PSEN1 ENSOARG00000000358 PSEN1 ENSOCUG00000014545 PSEN1 ENSCPOG00000035027 PSEN1 ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1 108395378 PSEN1 ENSRNOG00000009110 Psen1 ENSMODG00000006792 PSEN1	Compare expression
Mammalia	25 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Monodelphis domestica (opossum)	25 genes ENSMUSG00000019969 Psen1 ENSCAFG00000016815 PSEN1 ENSFCAG00000028093 PSEN1 ENSECAG00000004387 PSEN1 ENSSSCG00000002340 PSEN1 ENSBTAG00000011757 PSEN1 ENSCHIG00000025284 PSEN1 ENSOARG00000000358 PSEN1 ENSOCUG00000014545 PSEN1 ENSCPOG00000035027 PSEN1 ENSOANG00000001055 PSEN1 ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1 108395378 PSEN1 ENSRNOG00000009110 Psen1 ENSMODG00000006792 PSEN1	Compare expression
Amniota	28 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Monodelphis domestica (opossum) Anolis carolinensis (green anole)	28 genes ENSMUSG00000019969 Psen1 ENSCAFG00000016815 PSEN1 ENSFCAG00000028093 PSEN1 ENSECAG00000004387 PSEN1 ENSSSCG00000002340 PSEN1 ENSBTAG00000011757 PSEN1 ENSCHIG00000025284 PSEN1 ENSOARG00000000358 PSEN1 ENSOCUG00000014545 PSEN1 ENSCPOG00000035027 PSEN1 ENSGALG00000009320 PSEN1 ENSMGAG00000011694 PSEN1 ENSOANG00000001055 PSEN1 ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1 108395378 PSEN1 ENSRNOG00000009110 Psen1 ENSMODG00000006792 PSEN1 ENSACAG00000016176 PSEN1	Compare expression
Tetrapoda	30 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Monodelphis domestica (opossum) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole)	31 genes ENSMUSG00000019969 Psen1 ENSCAFG00000016815 PSEN1 ENSFCAG00000028093 PSEN1 ENSECAG00000004387 PSEN1 ENSSSCG00000002340 PSEN1 ENSBTAG00000011757 PSEN1 ENSCHIG00000025284 PSEN1 ENSOARG00000000358 PSEN1 ENSOCUG00000014545 PSEN1 ENSCPOG00000035027 PSEN1 ENSGALG00000009320 PSEN1 ENSMGAG00000011694 PSEN1 ENSOANG00000001055 PSEN1 ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1 108395378 PSEN1 ENSRNOG00000009110 Psen1 ENSMODG00000006792 PSEN1 108699733 psen1.S 399258 psen1 ENSXETG00000001008 psen1 ENSACAG00000016176 PSEN1	Compare expression
Bilateria	34 species Mus musculus (mouse) Drosophila melanogaster (fruit fly) Caenorhabditis elegans (nematode) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Monodelphis domestica (opossum) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole) Drosophila pseudoobscura () Drosophila simulans ()	35 genes ENSMUSG00000019969 Psen1 FBgn0284421 Psn WBGene00004769 sel-12 ENSCAFG00000016815 PSEN1 ENSFCAG00000028093 PSEN1 ENSECAG00000004387 PSEN1 ENSSSCG00000002340 PSEN1 ENSBTAG00000011757 PSEN1 ENSCHIG00000025284 PSEN1 ENSOARG00000000358 PSEN1 ENSOCUG00000014545 PSEN1 ENSCPOG00000035027 PSEN1 ENSGALG00000009320 PSEN1 ENSMGAG00000011694 PSEN1 ENSOANG00000001055 PSEN1 ENSCJAG00000014387 PSEN1 ENSCATG00000038778 PSEN1 ENSMFAG00000000113 PSEN1 ENSMMUG00000010173 PSEN1 ENSMNEG00000037289 PSEN1 ENSPANG00000006859 PSEN1 ENSGGOG00000002132 PSEN1 ENSPPAG00000038712 PSEN1 ENSPTRG00000006510 PSEN1 ENSMICG00000017923 PSEN1 ENSCSAG00000012773 PSEN1 108395378 PSEN1 ENSRNOG00000009110 Psen1 ENSMODG00000006792 PSEN1 108699733 psen1.S 399258 psen1 ENSXETG00000001008 psen1 ENSACAG00000016176 PSEN1 FBgn0075111 Dpse\GA15086 FBgn0186557 Dsim\GD14885	Compare expression

Showing 1 to 11 of 11 entries

Orthology information comes from OMA : ENSG00000080815.

Paralogs (same species)

Filter:

Taxon Name	Gene(s)	Expression comparison	See details
Chordata	2 genes ENSG00000143801 PSEN2 ENSG00000288674 AL391628.1	Compare expression: table \| graph

Showing 1 to 1 of 1 entries

Paralogy information comes from OMA : ENSG00000080815.

Cross-references

CCDS

CCDS9812 (CCDS9812.1),CCDS9813 (CCDS9813.1)

Ensembl

ENSG00000080815 (PSEN1)

HGNC

HGNC:9508 (PSEN1)

EMBL

AC004846,AC004858,AF109907,AF416717,AJ008005,AK312531,BC011729,CH471061

GeneCards

ENSG00000080815

UniProtKB/Swiss-Prot

P49768,PSN1_HUMAN

UniProtKB/TrEMBL

E7ES96,E7ES96_HUMAN,G3V2B1,G3V2B1_HUMAN,G3V2G7,G3V2G7_HUMAN,G3V3P0,G3V3P0_HUMAN