Search Genes

Gene : JAK1 - ENSG00000162434 - Homo sapiens (human)

General information

Expressed in type B pancreatic cell and 205 other cell types or tissues.

Gene identifier

ENSG00000162434

Name

JAK1

Description

Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190]

Organism

Homo sapiens (human)

Synonym(s)

jtk3,jak1b,jak1a

Orthologs

49 orthologs

Paralogs

3 paralogs

Source data

Retrieve all processed expression values for that gene

Expression graph

80%

Expression table

80%

Reported absence of expression

80%

Orthologs

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Taxon Name	Species with orthologs	Gene(s)	Expression comparison
Homininae	3 species Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee)	3 genes ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1	Compare expression
Catarrhini	9 species Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	9 genes ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSCSAG00000001351 JAK1	Compare expression
Simiiformes	10 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	10 genes ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSCSAG00000001351 JAK1	Compare expression
Primates	11 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey)	11 genes ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1	Compare expression
Euarchontoglires	15 species Mus musculus (mouse) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat)	15 genes ENSMUSG00000028530 Jak1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 ENSRNOG00000011157 Jak1	Compare expression
Boreoeutheria	23 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat)	23 genes ENSMUSG00000028530 Jak1 ENSCAFG00000018615 JAK1 ENSFCAG00000001953 JAK1 ENSECAG00000018673 JAK1 ENSSSCG00000003809 JAK1 ENSBTAG00000003147 JAK1 ENSCHIG00000012708 JAK1 ENSOARG00000010117 JAK1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 108405993 JAK1 ENSRNOG00000011157 Jak1	Compare expression
Mammalia	24 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat)	24 genes ENSMUSG00000028530 Jak1 ENSCAFG00000018615 JAK1 ENSFCAG00000001953 JAK1 ENSECAG00000018673 JAK1 ENSSSCG00000003809 JAK1 ENSBTAG00000003147 JAK1 ENSCHIG00000012708 JAK1 ENSOARG00000010117 JAK1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSOANG00000042832 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 108405993 JAK1 ENSRNOG00000011157 Jak1	Compare expression
Amniota	27 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Anolis carolinensis (green anole)	27 genes ENSMUSG00000028530 Jak1 ENSCAFG00000018615 JAK1 ENSFCAG00000001953 JAK1 ENSECAG00000018673 JAK1 ENSSSCG00000003809 JAK1 ENSBTAG00000003147 JAK1 ENSCHIG00000012708 JAK1 ENSOARG00000010117 JAK1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSGALG00000011031 JAK1 ENSMGAG00000011807 JAK1 ENSOANG00000042832 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 108405993 JAK1 ENSRNOG00000011157 Jak1 ENSACAG00000008478 JAK1	Compare expression
Tetrapoda	29 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole)	30 genes ENSMUSG00000028530 Jak1 ENSCAFG00000018615 JAK1 ENSFCAG00000001953 JAK1 ENSECAG00000018673 JAK1 ENSSSCG00000003809 JAK1 ENSBTAG00000003147 JAK1 ENSCHIG00000012708 JAK1 ENSOARG00000010117 JAK1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSGALG00000011031 JAK1 ENSMGAG00000011807 JAK1 ENSOANG00000042832 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 108405993 JAK1 ENSRNOG00000011157 Jak1 108714222 jak1.L ENSXETG00000020396 jak1 ENSXETG00000021329 slc39a8 ENSACAG00000008478 JAK1	Compare expression
Euteleostomi	42 species Mus musculus (mouse) Danio rerio (zebrafish) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole) Lepisosteus oculatus (Spotted gar) Anguilla anguilla (European freshwater eel) Astyanax mexicanus (Blind cave fish) Salmo salar (Atlantic salmon) Gadus morhua (Atlantic cod) Poecilia reticulata (Guppy) Oryzias latipes (Japanese rice fish) Astatotilapia calliptera (Eastern happy) Neolamprologus brichardi (Fairy cichlid) Scophthalmus maximus (Turbot) Gasterosteus aculeatus (Three-spined stickleback) Nothobranchius furzeri (Turquoise killifish)	46 genes ENSMUSG00000028530 Jak1 ENSDARG00000020625 jak1 ENSDARG00000117102 jak1 ENSCAFG00000018615 JAK1 ENSFCAG00000001953 JAK1 ENSECAG00000018673 JAK1 ENSSSCG00000003809 JAK1 ENSBTAG00000003147 JAK1 ENSCHIG00000012708 JAK1 ENSOARG00000010117 JAK1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSGALG00000011031 JAK1 ENSMGAG00000011807 JAK1 ENSOANG00000042832 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 108405993 JAK1 ENSRNOG00000011157 Jak1 108714222 jak1.L ENSXETG00000020396 jak1 ENSXETG00000021329 slc39a8 ENSACAG00000008478 JAK1 ENSLOCG00000006806 jak1 118225684 jak1 118229660 LOC118229660 ENSAMXG00000010587 jak1 ENSSSAG00000038503 jak1 ENSSSAG00000081097 jak1 ENSGMOG00000003132 jak1 ENSPREG00000020413 jak1 ENSORLG00000010063 jak1 ENSACLG00000001880 jak1 ENSNBRG00000014392 jak1 ENSSMAG00000020659 jak1 ENSGACG00000007145 jak1 ENSNFUG00015025398 JAK1	Compare expression
Chordata	43 species Mus musculus (mouse) Danio rerio (zebrafish) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole) Lepisosteus oculatus (Spotted gar) Anguilla anguilla (European freshwater eel) Astyanax mexicanus (Blind cave fish) Salmo salar (Atlantic salmon) Gadus morhua (Atlantic cod) Poecilia reticulata (Guppy) Oryzias latipes (Japanese rice fish) Astatotilapia calliptera (Eastern happy) Neolamprologus brichardi (Fairy cichlid) Scophthalmus maximus (Turbot) Gasterosteus aculeatus (Three-spined stickleback) Nothobranchius furzeri (Turquoise killifish) Branchiostoma lanceolatum (Common lancelet)	47 genes ENSMUSG00000028530 Jak1 ENSDARG00000020625 jak1 ENSDARG00000117102 jak1 ENSCAFG00000018615 JAK1 ENSFCAG00000001953 JAK1 ENSECAG00000018673 JAK1 ENSSSCG00000003809 JAK1 ENSBTAG00000003147 JAK1 ENSCHIG00000012708 JAK1 ENSOARG00000010117 JAK1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSGALG00000011031 JAK1 ENSMGAG00000011807 JAK1 ENSOANG00000042832 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 108405993 JAK1 ENSRNOG00000011157 Jak1 108714222 jak1.L ENSXETG00000020396 jak1 ENSXETG00000021329 slc39a8 ENSACAG00000008478 JAK1 ENSLOCG00000006806 jak1 118225684 jak1 118229660 LOC118229660 ENSAMXG00000010587 jak1 ENSSSAG00000038503 jak1 ENSSSAG00000081097 jak1 ENSGMOG00000003132 jak1 ENSPREG00000020413 jak1 ENSORLG00000010063 jak1 ENSACLG00000001880 jak1 ENSNBRG00000014392 jak1 ENSSMAG00000020659 jak1 ENSGACG00000007145 jak1 ENSNFUG00015025398 JAK1 BL10924 JAK2	Compare expression
Bilateria	45 species Mus musculus (mouse) Danio rerio (zebrafish) Drosophila melanogaster (fruit fly) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole) Lepisosteus oculatus (Spotted gar) Anguilla anguilla (European freshwater eel) Astyanax mexicanus (Blind cave fish) Salmo salar (Atlantic salmon) Gadus morhua (Atlantic cod) Poecilia reticulata (Guppy) Oryzias latipes (Japanese rice fish) Astatotilapia calliptera (Eastern happy) Neolamprologus brichardi (Fairy cichlid) Scophthalmus maximus (Turbot) Gasterosteus aculeatus (Three-spined stickleback) Nothobranchius furzeri (Turquoise killifish) Branchiostoma lanceolatum (Common lancelet) Drosophila pseudoobscura ()	49 genes ENSMUSG00000028530 Jak1 ENSDARG00000020625 jak1 ENSDARG00000117102 jak1 FBgn0004864 hop ENSCAFG00000018615 JAK1 ENSFCAG00000001953 JAK1 ENSECAG00000018673 JAK1 ENSSSCG00000003809 JAK1 ENSBTAG00000003147 JAK1 ENSCHIG00000012708 JAK1 ENSOARG00000010117 JAK1 ENSOCUG00000006227 JAK1 ENSCPOG00000005991 JAK1 ENSGALG00000011031 JAK1 ENSMGAG00000011807 JAK1 ENSOANG00000042832 JAK1 ENSCJAG00000016743 JAK1 ENSCATG00000041174 JAK1 ENSMFAG00000003493 JAK1 ENSMMUG00000018566 JAK1 ENSMNEG00000008188 JAK1 ENSPANG00000001284 JAK1 ENSGGOG00000016456 JAK1 ENSPPAG00000015344 JAK1 ENSPTRG00000000825 JAK1 ENSMICG00000013750 JAK1 ENSCSAG00000001351 JAK1 108405993 JAK1 ENSRNOG00000011157 Jak1 108714222 jak1.L ENSXETG00000020396 jak1 ENSXETG00000021329 slc39a8 ENSACAG00000008478 JAK1 ENSLOCG00000006806 jak1 118225684 jak1 118229660 LOC118229660 ENSAMXG00000010587 jak1 ENSSSAG00000038503 jak1 ENSSSAG00000081097 jak1 ENSGMOG00000003132 jak1 ENSPREG00000020413 jak1 ENSORLG00000010063 jak1 ENSACLG00000001880 jak1 ENSNBRG00000014392 jak1 ENSSMAG00000020659 jak1 ENSGACG00000007145 jak1 ENSNFUG00015025398 JAK1 BL10924 JAK2 FBgn0074067 Dpse\GA14036	Compare expression

Showing 1 to 12 of 12 entries

Orthology information comes from OMA : ENSG00000162434.

Paralogs (same species)

Filter:

Taxon Name	Gene(s)	Expression comparison	See details
Vertebrata	3 genes ENSG00000096968 JAK2 ENSG00000105397 TYK2 ENSG00000105639 JAK3	Compare expression: table \| graph

Showing 1 to 1 of 1 entries

Paralogy information comes from OMA : ENSG00000162434.

Cross-references

CCDS

CCDS41346 (CCDS41346.1)

Ensembl

ENSG00000162434 (JAK1)

HGNC

HGNC:6190 (JAK1)

EMBL

AB209057,AC093427,AL357078,AL590436,AL606517,BC132729,CH471059,KC876867

GeneCards

ENSG00000162434

UniProtKB/Swiss-Prot

JAK1_HUMAN,P23458

UniProtKB/TrEMBL

A0A5F9ZH07,A0A5F9ZH07_HUMAN,A0A5F9ZH32,A0A5F9ZH32_HUMAN,A0A5F9ZH73,A0A5F9ZH73_HUMAN,A0A5F9ZHI1,A0A5F9ZHI1_HUMAN