Search Genes

Gene : SIRT6 - ENSG00000077463 - Homo sapiens (human)

General information

Expressed in mucosa of transverse colon and 134 other cell types or tissues.

Gene identifier

ENSG00000077463

Name

SIRT6

Description

sirtuin 6 [Source:HGNC Symbol;Acc:HGNC:14934]

Organism

Homo sapiens (human)

Synonym(s)

Orthologs

43 orthologs

Paralogs

5 paralogs

Source data

Retrieve all processed expression values for that gene

Expression graph

80%

Expression table

80%

Reported absence of expression

80%

Orthologs

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Taxon Name	Species with orthologs	Gene(s)	Expression comparison
Homininae	3 species Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee)	3 genes ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6	Compare expression
Catarrhini	9 species Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	9 genes ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSCSAG00000010757 SIRT6	Compare expression
Simiiformes	10 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	10 genes ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSCSAG00000010757 SIRT6	Compare expression
Primates	11 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey)	11 genes ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6	Compare expression
Euarchontoglires	13 species Mus musculus (mouse) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat)	13 genes ENSMUSG00000034748 Sirt6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 ENSRNOG00000006393 Sirt6	Compare expression
Boreoeutheria	21 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat)	21 genes ENSMUSG00000034748 Sirt6 ENSCAFG00000019123 SIRT6 ENSFCAG00000014140 SIRT6 ENSECAG00000015304 SIRT6 ENSSSCG00000013496 SIRT6 ENSBTAG00000019909 SIRT6 ENSCHIG00000025871 SIRT6 ENSOARG00000010598 SIRT6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 108385044 SIRT6 ENSRNOG00000006393 Sirt6	Compare expression
Mammalia	22 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat)	22 genes ENSMUSG00000034748 Sirt6 ENSCAFG00000019123 SIRT6 ENSFCAG00000014140 SIRT6 ENSECAG00000015304 SIRT6 ENSSSCG00000013496 SIRT6 ENSBTAG00000019909 SIRT6 ENSCHIG00000025871 SIRT6 ENSOARG00000010598 SIRT6 ENSOANG00000008787 SIRT6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 108385044 SIRT6 ENSRNOG00000006393 Sirt6	Compare expression
Amniota	24 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat)	24 genes ENSMUSG00000034748 Sirt6 ENSCAFG00000019123 SIRT6 ENSFCAG00000014140 SIRT6 ENSECAG00000015304 SIRT6 ENSSSCG00000013496 SIRT6 ENSBTAG00000019909 SIRT6 ENSCHIG00000025871 SIRT6 ENSOARG00000010598 SIRT6 ENSGALG00000001245 SIRT6 ENSMGAG00000002932 SIRT6 ENSOANG00000008787 SIRT6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 108385044 SIRT6 ENSRNOG00000006393 Sirt6	Compare expression
Tetrapoda	26 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog)	27 genes ENSMUSG00000034748 Sirt6 ENSCAFG00000019123 SIRT6 ENSFCAG00000014140 SIRT6 ENSECAG00000015304 SIRT6 ENSSSCG00000013496 SIRT6 ENSBTAG00000019909 SIRT6 ENSCHIG00000025871 SIRT6 ENSOARG00000010598 SIRT6 ENSGALG00000001245 SIRT6 ENSMGAG00000002932 SIRT6 ENSOANG00000008787 SIRT6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 108385044 SIRT6 ENSRNOG00000006393 Sirt6 100037190 sirt6.L 444018 sirt6.S ENSXETG00000027525 sirt6	Compare expression
Sarcopterygii	27 species Mus musculus (mouse) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Latimeria chalumnae (Coelacanth)	28 genes ENSMUSG00000034748 Sirt6 ENSCAFG00000019123 SIRT6 ENSFCAG00000014140 SIRT6 ENSECAG00000015304 SIRT6 ENSSSCG00000013496 SIRT6 ENSBTAG00000019909 SIRT6 ENSCHIG00000025871 SIRT6 ENSOARG00000010598 SIRT6 ENSGALG00000001245 SIRT6 ENSMGAG00000002932 SIRT6 ENSOANG00000008787 SIRT6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 108385044 SIRT6 ENSRNOG00000006393 Sirt6 100037190 sirt6.L 444018 sirt6.S ENSXETG00000027525 sirt6 ENSLACG00000007794 SIRT6	Compare expression
Euteleostomi	39 species Mus musculus (mouse) Danio rerio (zebrafish) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anguilla anguilla (European freshwater eel) Esox lucius (Northern pike) Salmo salar (Atlantic salmon) Gadus morhua (Atlantic cod) Poecilia reticulata (Guppy) Oryzias latipes (Japanese rice fish) Astatotilapia calliptera (Eastern happy) Neolamprologus brichardi (Fairy cichlid) Scophthalmus maximus (Turbot) Gasterosteus aculeatus (Three-spined stickleback) Nothobranchius furzeri (Turquoise killifish) Latimeria chalumnae (Coelacanth)	40 genes ENSMUSG00000034748 Sirt6 ENSDARG00000102963 sirt6 ENSCAFG00000019123 SIRT6 ENSFCAG00000014140 SIRT6 ENSECAG00000015304 SIRT6 ENSSSCG00000013496 SIRT6 ENSBTAG00000019909 SIRT6 ENSCHIG00000025871 SIRT6 ENSOARG00000010598 SIRT6 ENSGALG00000001245 SIRT6 ENSMGAG00000002932 SIRT6 ENSOANG00000008787 SIRT6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 108385044 SIRT6 ENSRNOG00000006393 Sirt6 100037190 sirt6.L 444018 sirt6.S ENSXETG00000027525 sirt6 118229425 sirt6 ENSELUG00000008030 sirt6 ENSSSAG00000080789 sirt6 ENSGMOG00000012243 sirt6 ENSPREG00000017600 sirt6 ENSORLG00000014983 sirt6 ENSACLG00000003087 sirt6 ENSNBRG00000020268 sirt6 ENSSMAG00000003421 sirt6 ENSGACG00000015316 sirt6 ENSNFUG00015016584 SIRT6 ENSLACG00000007794 SIRT6	Compare expression
Bilateria	42 species Mus musculus (mouse) Danio rerio (zebrafish) Drosophila melanogaster (fruit fly) Caenorhabditis elegans (nematode) Canis lupus familiaris (dog) Felis catus (cat) Equus caballus (horse) Sus scrofa (pig) Bos taurus (cattle) Capra hircus (Goat) Ovis aries (Sheep) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Manis javanica (Malayan pangolin) Rattus norvegicus (rat) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anguilla anguilla (European freshwater eel) Esox lucius (Northern pike) Salmo salar (Atlantic salmon) Gadus morhua (Atlantic cod) Poecilia reticulata (Guppy) Oryzias latipes (Japanese rice fish) Astatotilapia calliptera (Eastern happy) Neolamprologus brichardi (Fairy cichlid) Scophthalmus maximus (Turbot) Gasterosteus aculeatus (Three-spined stickleback) Nothobranchius furzeri (Turquoise killifish) Latimeria chalumnae (Coelacanth) Drosophila simulans ()	43 genes ENSMUSG00000034748 Sirt6 ENSDARG00000102963 sirt6 FBgn0037802 Sirt6 WBGene00004803 sir-2.4 ENSCAFG00000019123 SIRT6 ENSFCAG00000014140 SIRT6 ENSECAG00000015304 SIRT6 ENSSSCG00000013496 SIRT6 ENSBTAG00000019909 SIRT6 ENSCHIG00000025871 SIRT6 ENSOARG00000010598 SIRT6 ENSGALG00000001245 SIRT6 ENSMGAG00000002932 SIRT6 ENSOANG00000008787 SIRT6 ENSCJAG00000015120 SIRT6 ENSCATG00000039436 SIRT6 ENSMFAG00000001546 SIRT6 ENSMMUG00000019955 SIRT6 ENSMNEG00000029466 SIRT6 ENSPANG00000004922 SIRT6 ENSGGOG00000008838 SIRT6 ENSPPAG00000034387 SIRT6 ENSPTRG00000010296 SIRT6 ENSMICG00000003439 SIRT6 ENSCSAG00000010757 SIRT6 108385044 SIRT6 ENSRNOG00000006393 Sirt6 100037190 sirt6.L 444018 sirt6.S ENSXETG00000027525 sirt6 118229425 sirt6 ENSELUG00000008030 sirt6 ENSSSAG00000080789 sirt6 ENSGMOG00000012243 sirt6 ENSPREG00000017600 sirt6 ENSORLG00000014983 sirt6 ENSACLG00000003087 sirt6 ENSNBRG00000020268 sirt6 ENSSMAG00000003421 sirt6 ENSGACG00000015316 sirt6 ENSNFUG00015016584 SIRT6 ENSLACG00000007794 SIRT6 FBgn0192191 Dsim\GD20725	Compare expression

Showing 1 to 12 of 12 entries

Orthology information comes from OMA : ENSG00000077463.

Paralogs (same species)

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Taxon Name	Gene(s)	Expression comparison	See details
Opisthokonta	5 genes ENSG00000068903 SIRT2 ENSG00000089163 SIRT4 ENSG00000124523 SIRT5 ENSG00000142082 SIRT3 ENSG00000187531 SIRT7	Compare expression: table \| graph

Showing 1 to 1 of 1 entries

Paralogy information comes from OMA : ENSG00000077463.

Cross-references

CCDS

CCDS12122 (CCDS12122.1),CCDS54199 (CCDS54199.1),CCDS82275 (CCDS82275.1),CCDS82276 (CCDS82276.1)

Ensembl

ENSG00000077463 (SIRT6)

HGNC

HGNC:14934 (SIRT6)

EMBL

AC005620,AC006930,AC016586,AF233396,AK074810,AK315048,BC004218,BC005026

GeneCards

ENSG00000077463

UniProtKB/Swiss-Prot

Q8N6T7,SIR6_HUMAN

UniProtKB/TrEMBL

M0QXA0,M0QXA0_HUMAN,M0QZ09,M0QZ09_HUMAN,M0R0B2,M0R0B2_HUMAN,M0R1F6,M0R1F6_HUMAN